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ADGRB2 adhesion G protein-coupled receptor B2 [ Homo sapiens (human) ]

Gene ID: 576, updated on 26-Oct-2022

Summary

Official Symbol
ADGRB2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B2provided by HGNC
Primary source
HGNC:HGNC:944
See related
Ensembl:ENSG00000121753 MIM:602683; AllianceGenome:HGNC:944
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI2
Summary
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADGRB2 in Genome Data Viewer
Location:
1p35.2
Exon count:
33
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (31727117..31764340, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (31584757..31621990, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32192718..32229941, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene collagen type XVI alpha 1 chain Neighboring gene uncharacterized LOC101929444 Neighboring gene Sharpr-MPRA regulatory region 11964 Neighboring gene uncharacterized LOC124903930 Neighboring gene microRNA 4254 Neighboring gene SPOC domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor B2
Names
brain-specific angiogenesis inhibitor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294335.2NP_001281264.1  adhesion G protein-coupled receptor B2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001281264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AB005298, AC114488, AI291691, AL354919, DA494051
    Consensus CDS
    CCDS72747.1
    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000362759.2, ENST00000373655.6
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  2. NM_001294336.2NP_001281265.1  adhesion G protein-coupled receptor B2 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB005298, AC114488, AI291691, AL354919, BC136533, DA494051
    Consensus CDS
    CCDS72746.1
    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  3. NM_001364857.2NP_001351786.1  adhesion G protein-coupled receptor B2 isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC114488, AL354919
    Consensus CDS
    CCDS346.2
    UniProtKB/Swiss-Prot
    Q96GZ9
    Related
    ENSP00000362762.3, ENST00000373658.8
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:614771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9291219
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    31727117..31764340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541858.3XP_011540160.1  adhesion G protein-coupled receptor B2 isoform X26

    Conserved Domains (5) summary
    smart00303
    Location:567620
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:228292
    HormR; Domain present in hormone receptors
    smart00209
    Location:64114
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:626916
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:311466
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  2. XM_047426187.1XP_047282143.1  adhesion G protein-coupled receptor B2 isoform X20

  3. XM_047426186.1XP_047282142.1  adhesion G protein-coupled receptor B2 isoform X18

  4. XM_047426180.1XP_047282136.1  adhesion G protein-coupled receptor B2 isoform X11

  5. XM_047426178.1XP_047282134.1  adhesion G protein-coupled receptor B2 isoform X7

  6. XM_017001899.2XP_016857388.1  adhesion G protein-coupled receptor B2 isoform X1

    UniProtKB/Swiss-Prot
    O60241, Q96GZ9
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:614771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9291219
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  7. XM_047426181.1XP_047282137.1  adhesion G protein-coupled receptor B2 isoform X11

  8. XM_047426173.1XP_047282129.1  adhesion G protein-coupled receptor B2 isoform X1

    UniProtKB/Swiss-Prot
    Q96GZ9
  9. XM_047426188.1XP_047282144.1  adhesion G protein-coupled receptor B2 isoform X23

    UniProtKB/TrEMBL
    A2A3C1
    Related
    ENSP00000381550.1, ENST00000398542.5
  10. XM_047426185.1XP_047282141.1  adhesion G protein-coupled receptor B2 isoform X17

  11. XM_047426184.1XP_047282140.1  adhesion G protein-coupled receptor B2 isoform X16

  12. XM_017001903.2XP_016857392.1  adhesion G protein-coupled receptor B2 isoform X6

  13. XM_017001902.2XP_016857391.1  adhesion G protein-coupled receptor B2 isoform X5

  14. XM_017001909.2XP_016857398.1  adhesion G protein-coupled receptor B2 isoform X14

    Related
    ENSP00000381555.1, ENST00000398547.5
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  15. XM_047426190.1XP_047282146.1  adhesion G protein-coupled receptor B2 isoform X25

  16. XM_047426189.1XP_047282145.1  adhesion G protein-coupled receptor B2 isoform X24

  17. XM_047426183.1XP_047282139.1  adhesion G protein-coupled receptor B2 isoform X15

  18. XM_047426179.1XP_047282135.1  adhesion G protein-coupled receptor B2 isoform X10

  19. XM_017001900.2XP_016857389.1  adhesion G protein-coupled receptor B2 isoform X2

    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  20. XM_017001901.2XP_016857390.1  adhesion G protein-coupled receptor B2 isoform X4

    Related
    ENSP00000381548.1, ENST00000398538.5
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  21. XM_024448673.2XP_024304441.1  adhesion G protein-coupled receptor B2 isoform X3

    Conserved Domains (5) summary
    smart00303
    Location:858911
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:519583
    HormR; Domain present in hormone receptors
    smart00209
    Location:355405
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:602759
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9171207
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  22. XM_017001911.2XP_016857400.1  adhesion G protein-coupled receptor B2 isoform X21

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  23. XM_017001908.2XP_016857397.1  adhesion G protein-coupled receptor B2 isoform X12

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  24. XM_047426182.1XP_047282138.1  adhesion G protein-coupled receptor B2 isoform X13

  25. XM_017001905.2XP_016857394.1  adhesion G protein-coupled receptor B2 isoform X8

    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000435397.1, ENST00000527361.5
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  26. XM_017001906.2XP_016857395.1  adhesion G protein-coupled receptor B2 isoform X9

  27. XM_017001912.2XP_016857401.1  adhesion G protein-coupled receptor B2 isoform X22

    Conserved Domains (5) summary
    smart00303
    Location:760813
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:421485
    HormR; Domain present in hormone receptors
    smart00209
    Location:368418
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8191088
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:505662
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  28. XM_017001910.2XP_016857399.1  adhesion G protein-coupled receptor B2 isoform X19

    Related
    ENSP00000381564.3, ENST00000398556.7
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  29. XM_047426191.1XP_047282147.1  adhesion G protein-coupled receptor B2 isoform X27

    Related
    ENSP00000410921.1, ENST00000420125.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    31584757..31621990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)