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ADGRB2 adhesion G protein-coupled receptor B2 [ Homo sapiens (human) ]

Gene ID: 576, updated on 1-Jun-2020

Summary

Official Symbol
ADGRB2provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B2provided by HGNC
Primary source
HGNC:HGNC:944
See related
Ensembl:ENSG00000121753 MIM:602683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI2
Summary
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues See more
Orthologs

Genomic context

See ADGRB2 in Genome Data Viewer
Location:
1p35.2
Exon count:
32
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (31727105..31764340, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32192718..32230494, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929444 Neighboring gene collagen type XVI alpha 1 chain Neighboring gene Sharpr-MPRA regulatory region 11964 Neighboring gene microRNA 4254 Neighboring gene SPOC domain containing 1 Neighboring gene protein tyrosine phosphatase 4A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor B2
Names
brain-specific angiogenesis inhibitor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294335.2NP_001281264.1  adhesion G protein-coupled receptor B2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001281264.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AB005298, AC114488, AI291691, AL354919, DA494051
    Consensus CDS
    CCDS72747.1
    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000362759.2, ENST00000373655.6
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  2. NM_001294336.2NP_001281265.1  adhesion G protein-coupled receptor B2 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB005298, AC114488, AI291691, AL354919, BC136533, DA494051
    Consensus CDS
    CCDS72746.1
    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  3. NM_001364857.2NP_001351786.1  adhesion G protein-coupled receptor B2 isoform 3 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AC114488, AL354919
    Related
    ENSP00000362762.3, ENST00000373658.7
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:614771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9291219
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    31727105..31764340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541849.2XP_011540151.1  adhesion G protein-coupled receptor B2 isoform X3

    See identical proteins and their annotated locations for XP_011540151.1

    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000381550.1, ENST00000398542.5
    Conserved Domains (5) summary
    smart00303
    Location:858911
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:519583
    HormR; Domain present in hormone receptors
    smart00209
    Location:355405
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:602759
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9171207
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  2. XM_017001899.1XP_016857388.1  adhesion G protein-coupled receptor B2 isoform X1

    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:614771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9291219
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  3. XM_011541858.2XP_011540160.1  adhesion G protein-coupled receptor B2 isoform X16

    Conserved Domains (5) summary
    smart00303
    Location:567620
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:228292
    HormR; Domain present in hormone receptors
    smart00209
    Location:64114
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:626895
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:312469
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  4. XM_017001903.1XP_016857392.1  adhesion G protein-coupled receptor B2 isoform X6

  5. XM_017001902.1XP_016857391.1  adhesion G protein-coupled receptor B2 isoform X5

  6. XM_017001900.1XP_016857389.1  adhesion G protein-coupled receptor B2 isoform X2

    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  7. XM_017001901.1XP_016857390.1  adhesion G protein-coupled receptor B2 isoform X4

    Related
    ENSP00000381548.1, ENST00000398538.5
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291198
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  8. XM_011541848.3XP_011540150.1  adhesion G protein-coupled receptor B2 isoform X1

    See identical proteins and their annotated locations for XP_011540150.1

    UniProtKB/Swiss-Prot
    O60241
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:614771
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9291219
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  9. XM_017001909.1XP_016857398.1  adhesion G protein-coupled receptor B2 isoform X12

    Related
    ENSP00000381555.1, ENST00000398547.5
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  10. XM_017001905.1XP_016857394.1  adhesion G protein-coupled receptor B2 isoform X8

    UniProtKB/Swiss-Prot
    O60241
    Related
    ENSP00000435397.1, ENST00000527361.5
    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  11. XM_024448673.1XP_024304441.1  adhesion G protein-coupled receptor B2 isoform X3

    Conserved Domains (5) summary
    smart00303
    Location:858911
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:519583
    HormR; Domain present in hormone receptors
    smart00209
    Location:355405
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:602759
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15988
    Location:9171207
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  12. XM_017001911.1XP_016857400.1  adhesion G protein-coupled receptor B2 isoform X14

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  13. XM_017001908.1XP_016857397.1  adhesion G protein-coupled receptor B2 isoform X11

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  14. XM_017001906.1XP_016857395.1  adhesion G protein-coupled receptor B2 isoform X9

  15. XM_017001910.1XP_016857399.1  adhesion G protein-coupled receptor B2 isoform X13

    Related
    ENSP00000381564.3, ENST00000398556.7
    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:312362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741110
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  16. XM_017001907.1XP_016857396.1  adhesion G protein-coupled receptor B2 isoform X10

    Conserved Domains (5) summary
    smart00303
    Location:815868
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:476540
    HormR; Domain present in hormone receptors
    smart00209
    Location:314362
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8741143
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:560717
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  17. XM_017001904.1XP_016857393.1  adhesion G protein-coupled receptor B2 isoform X7

    Conserved Domains (5) summary
    smart00303
    Location:870923
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:531595
    HormR; Domain present in hormone receptors
    smart00209
    Location:367417
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9291165
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:615772
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  18. XM_017001912.1XP_016857401.1  adhesion G protein-coupled receptor B2 isoform X15

    Conserved Domains (5) summary
    smart00303
    Location:760813
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:421485
    HormR; Domain present in hormone receptors
    smart00209
    Location:368418
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:8191088
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:505662
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RNA

  1. XR_001737343.1 RNA Sequence

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