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Adgrb2 adhesion G protein-coupled receptor B2 [ Mus musculus (house mouse) ]

Gene ID: 230775, updated on 9-Mar-2023

Summary

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Official Symbol
Adgrb2provided by MGI
Official Full Name
adhesion G protein-coupled receptor B2provided by MGI
Primary source
MGI:MGI:2451244
See related
Ensembl:ENSMUSG00000028782 AllianceGenome:MGI:2451244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bai2
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within peripheral nervous system development and positive regulation of synapse assembly. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; endocrine gland; genitourinary system; spleen; and visual system. Orthologous to human ADGRB2 (adhesion G protein-coupled receptor B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 58.2), frontal lobe adult (RPKM 48.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrb2 in Genome Data Viewer
Location:
4; 4 D2.2
Exon count:
32
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129878566..129916426)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129984773..130022633)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700003M07 gene Neighboring gene predicted gene, 54260 Neighboring gene predicted gene 12963 Neighboring gene collagen, type XVI, alpha 1 Neighboring gene predicted gene, 46871

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Speca DJ, et al. Mamm Genome, 2017 Dec. PMID 28894906, Free PMC Article
  2. A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference. Wang CY, et al. Neuron, 2020 Jul 8. PMID 32369733, Free PMC Article
  3. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. Jeong BC, et al. FEBS Lett, 2006 Jan 23. PMID 16412436
  4. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. Okajima D, et al. J Recept Signal Transduct Res, 2010 Jun. PMID 20367554
  5. Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma. Kee HJ, et al. FEBS Lett, 2004 Jul 2. PMID 15225653

See all (29) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surface expression of Bai2 R619W is markedly reduced relative to wild-type Bai2.
    Title: Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL.
  2. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway
    Title: Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing.
  3. Results point out that brain-specific angiogenesis inhibitor 2 controls VEGF transcription through GA-binding protein under normal conditions and cerebral ischemia.
    Title: Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within peripheral nervous system development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor B2
Names
G protein-coupled receptor brain-specific angiogenesis inhibitor 1
brain-specific angiogenesis inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199696.2 → NP_001186625.1  adhesion G protein-coupled receptor B2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Consensus CDS
    CCDS57300.1
    UniProtKB/Swiss-Prot
    Q8CGM1
    Related
    ENSMUSP00000112869.2, ENSMUST00000121049.8
    Conserved Domains (5) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:303 → 353
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:868 → 1137
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:551 → 708
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  2. NM_001290714.2 → NP_001277643.1  adhesion G protein-coupled receptor B2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Consensus CDS
    CCDS71478.1
    UniProtKB/Swiss-Prot
    Q8CGM1
    UniProtKB/TrEMBL
    B1ASC0
    Related
    ENSMUSP00000112524.2, ENSMUST00000120204.8
    Conserved Domains (5) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:305 → 353
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:868 → 1104
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:551 → 708
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. NM_001290715.2 → NP_001277644.1  adhesion G protein-coupled receptor B2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277644.1

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Consensus CDS
    CCDS80164.1
    UniProtKB/Swiss-Prot
    Q6PGN0, Q8CGM1
    Related
    ENSMUSP00000101636.3, ENSMUST00000106015.9
    Conserved Domains (5) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:923 → 1192
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:606 → 763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. NM_001377056.1 → NP_001363985.1  adhesion G protein-coupled receptor B2 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Conserved Domains (6) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd14964
    Location:925 → 950
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam16489
    Location:605 → 760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:923 → 1180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. NM_001377057.1 → NP_001363986.1  adhesion G protein-coupled receptor B2 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Related
    ENSMUSP00000101639.3, ENSMUST00000106018.9
    Conserved Domains (6) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:303 → 353
    TSP1; Thrombospondin type 1 repeats
    cd14964
    Location:870 → 895
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam16489
    Location:550 → 705
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:868 → 1125
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  6. NM_001377058.1 → NP_001363987.1  adhesion G protein-coupled receptor B2 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Conserved Domains (6) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:303 → 353
    TSP1; Thrombospondin type 1 repeats
    cd14964
    Location:870 → 895
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam16489
    Location:550 → 705
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:868 → 1125
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  7. NM_173071.4 → NP_775094.2  adhesion G protein-coupled receptor B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_775094.2

    Status: VALIDATED

    Source sequence(s)
    AL626774
    Consensus CDS
    CCDS51309.1
    UniProtKB/Swiss-Prot
    Q8CGM1
    Related
    ENSMUSP00000101638.2, ENSMUST00000106017.8
    Conserved Domains (5) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:923 → 1180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:606 → 763
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129878566..129916426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240507.2 → XP_011238809.1  adhesion G protein-coupled receptor B2 isoform X2

    Conserved Domains (5) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:923 → 1234
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:605 → 760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  2. XM_030253457.1 → XP_030109317.1  adhesion G protein-coupled receptor B2 isoform X6

    Conserved Domains (5) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:305 → 353
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:868 → 1179
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:550 → 705
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  3. XM_030253456.1 → XP_030109316.1  adhesion G protein-coupled receptor B2 isoform X5

    Conserved Domains (5) summary
    smart00303
    Location:809 → 862
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:467 → 531
    HormR; Domain present in hormone receptors
    smart00209
    Location:303 → 353
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:868 → 1179
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:550 → 705
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  4. XM_030253459.1 → XP_030109319.1  adhesion G protein-coupled receptor B2 isoform X7

    Conserved Domains (5) summary
    smart00303
    Location:754 → 807
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:412 → 476
    HormR; Domain present in hormone receptors
    smart00209
    Location:359 → 409
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:813 → 1124
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:495 → 650
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  5. XM_036164059.1 → XP_036019952.1  adhesion G protein-coupled receptor B2 isoform X8

    Conserved Domains (6) summary
    smart00303
    Location:726 → 779
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:384 → 448
    HormR; Domain present in hormone receptors
    smart00209
    Location:331 → 381
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:785 → 1096
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:467 → 624
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:26 → 221
    AGRB_N; Adhesion GPCR B N-terminal region

  6. XM_011240506.1 → XP_011238808.1  adhesion G protein-coupled receptor B2 isoform X1

    Conserved Domains (5) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:923 → 1234
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:605 → 760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  7. XM_011240508.1 → XP_011238810.1  adhesion G protein-coupled receptor B2 isoform X3

    Related
    ENSMUSP00000030571.7, ENSMUST00000030571.7
    Conserved Domains (5) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd15988
    Location:923 → 1213
    7tmB2_BAI2; brain-specific angiogenesis inhibitor 2, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:605 → 760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

  8. XM_011240512.1 → XP_011238814.1  adhesion G protein-coupled receptor B2 isoform X4

    Related
    ENSMUSP00000095480.4, ENSMUST00000097868.10
    Conserved Domains (6) summary
    smart00303
    Location:864 → 917
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:522 → 586
    HormR; Domain present in hormone receptors
    smart00209
    Location:358 → 408
    TSP1; Thrombospondin type 1 repeats
    cd14964
    Location:925 → 950
    7tm_GPCRs; TM helix 1 [structural motif]
    pfam16489
    Location:605 → 760
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl28897
    Location:923 → 1180
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RNA

  1. XR_004941876.1 RNA Sequence

  2. XR_004941877.1 RNA Sequence

  3. XR_004941874.1 RNA Sequence

  4. XR_004941875.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGM1.2 GenPept UniProtKB/Swiss-Prot:Q8CGM1

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