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ARHGAP21 Rho GTPase activating protein 21 [ Homo sapiens (human) ]

Gene ID: 57584, updated on 18-Aug-2020

Summary

Official Symbol
ARHGAP21provided by HGNC
Official Full Name
Rho GTPase activating protein 21provided by HGNC
Primary source
HGNC:HGNC:23725
See related
Ensembl:ENSG00000107863 MIM:609870
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGAP10
Summary
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more
Orthologs

Genomic context

See ARHGAP21 in Genome Data Viewer
Location:
10p12.1; 10p12.3
Exon count:
33
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (24583610..24725421, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (24872538..25012597, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene KIAA1217 Neighboring gene microRNA 603 Neighboring gene uncharacterized LOC105376455 Neighboring gene RNA, 5S ribosomal pseudogene 305 Neighboring gene coenzyme Q10B pseudogene 1 Neighboring gene uncharacterized LOC105376456 Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene RN7SK pseudogene 241

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33323, FLJ90108, DKFZp761L0424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of Golgi localization IDA
Inferred from Direct Assay
more info
PubMed 
maintenance of Golgi location IMP
Inferred from Mutant Phenotype
more info
PubMed 
organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 21
Names
Rho-GTPase activating protein 10
rho GTPase-activating protein 10
rho-type GTPase-activating protein 21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367447.1NP_001354376.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
  2. NM_001367448.1NP_001354377.1  rho GTPase-activating protein 21 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AL355979, AL392104
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  3. NM_001367449.1NP_001354378.1  rho GTPase-activating protein 21 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.
    Source sequence(s)
    AL355979, AL392104
  4. NM_001367450.1NP_001354379.1  rho GTPase-activating protein 21 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AL355979, AL392104
  5. NM_001367451.1NP_001354380.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
  6. NM_001367452.1NP_001354381.1  rho GTPase-activating protein 21 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  7. NM_001367453.1NP_001354382.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
  8. NM_001367454.1NP_001354383.1  rho GTPase-activating protein 21 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AL355979, AL392104
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  9. NM_001367455.1NP_001354384.1  rho GTPase-activating protein 21 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL392104
    Related
    ENST00000486374.5
  10. NM_020824.4NP_065875.3  rho GTPase-activating protein 21 isoform a

    See identical proteins and their annotated locations for NP_065875.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AB037845, AF480466, AL355979, AV709499, BI491305, BQ026288
    Consensus CDS
    CCDS7144.2
    UniProtKB/Swiss-Prot
    Q5T5U3
    Related
    ENSP00000379709.2, ENST00000396432.7
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RNA

  1. NR_160021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  2. NR_160022.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  3. NR_160023.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  4. NR_160024.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL392104
  5. NR_160025.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL392104

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    24583610..24725421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519605.2XP_011517907.1  rho GTPase-activating protein 21 isoform X2

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11681363
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9571066
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9581063
    PH; PH domain
  2. XM_011519607.2XP_011517909.1  rho GTPase-activating protein 21 isoform X7

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  3. XM_011519602.2XP_011517904.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517904.1

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  4. XM_011519604.2XP_011517906.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517906.1

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  5. XM_017016459.2XP_016871948.1  rho GTPase-activating protein 21 isoform X3

    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  6. XM_011519603.3XP_011517905.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517905.1

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  7. XM_024448088.1XP_024303856.1  rho GTPase-activating protein 21 isoform X6

    Conserved Domains (3) summary
    cd00992
    Location:3487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11001295
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:889998
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  8. XM_011519606.2XP_011517908.1  rho GTPase-activating protein 21 isoform X5

    Conserved Domains (4) summary
    cd00992
    Location:3487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11101305
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:8991008
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9001005
    PH; PH domain

RNA

  1. XR_242701.5 RNA Sequence

  2. XR_930513.3 RNA Sequence

  3. XR_001747163.2 RNA Sequence

  4. XR_001747160.2 RNA Sequence

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