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ARHGAP21 Rho GTPase activating protein 21 [ Homo sapiens (human) ]

Gene ID: 57584, updated on 1-Mar-2024

Summary

Official Symbol
ARHGAP21provided by HGNC
Official Full Name
Rho GTPase activating protein 21provided by HGNC
Primary source
HGNC:HGNC:23725
See related
Ensembl:ENSG00000107863 MIM:609870; AllianceGenome:HGNC:23725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGAP10
Summary
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 26.0), fat (RPKM 12.0) and 25 other tissues See more
Orthologs
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Genomic context

See ARHGAP21 in Genome Data Viewer
Location:
10p12.1; 10p12.3
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (24583614..24723887, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (24602382..24742515, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (24872543..25012816, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene KIAA1217 Neighboring gene uncharacterized LOC105376455 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:24751397-24751898 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11630 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:24782535-24783036 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:24783037-24783536 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:24783692-24784472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:24790381-24790881 Neighboring gene uncharacterized LOC124902394 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:24821078-24822277 Neighboring gene Sharpr-MPRA regulatory region 10635 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:24847550-24847997 Neighboring gene NANOG hESC enhancer GRCh37_chr10:24868778-24869279 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:24901387-24901576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2222 Neighboring gene RNA, 5S ribosomal pseudogene 305 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2223 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2224 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:25012349-25013259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2228 Neighboring gene coenzyme Q10B pseudogene 1 Neighboring gene uncharacterized LOC105376456 Neighboring gene MPRA-validated peak910 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:25051766-25052318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3160 Neighboring gene phosphoribosyl transferase domain containing 1 Neighboring gene RN7SK pseudogene 241

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ33323, FLJ90108, DKFZp761L0424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in Golgi localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of Golgi localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in maintenance of Golgi location IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 21
Names
Rho-GTPase activating protein 10
rho GTPase-activating protein 10
rho-type GTPase-activating protein 21

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367447.1NP_001354376.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
    Consensus CDS
    CCDS91222.1
    UniProtKB/TrEMBL
    A0A2X0SF83, A0A805TBS0
  2. NM_001367448.1NP_001354377.1  rho GTPase-activating protein 21 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AL355979, AL392104
    Consensus CDS
    CCDS7144.2
    UniProtKB/Swiss-Prot
    Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
    UniProtKB/TrEMBL
    A0A2X0SF83
    Related
    ENSP00000506388.1, ENST00000680286.1
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  3. NM_001367449.1NP_001354378.1  rho GTPase-activating protein 21 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform c.
    Source sequence(s)
    AL355979, AL392104
    UniProtKB/TrEMBL
    A0A2X0SF83
  4. NM_001367450.1NP_001354379.1  rho GTPase-activating protein 21 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform c.
    Source sequence(s)
    AL355979, AL392104
    UniProtKB/TrEMBL
    A0A2X0SF83
  5. NM_001367451.1NP_001354380.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
    Consensus CDS
    CCDS91222.1
    UniProtKB/TrEMBL
    A0A2X0SF83, A0A805TBS0
    Related
    ENSP00000365592.3, ENST00000376410.7
  6. NM_001367452.1NP_001354381.1  rho GTPase-activating protein 21 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
    UniProtKB/TrEMBL
    A0A2X0SF83
  7. NM_001367453.1NP_001354382.1  rho GTPase-activating protein 21 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform b.
    Source sequence(s)
    AL355979, AL392104
    Consensus CDS
    CCDS91222.1
    UniProtKB/TrEMBL
    A0A2X0SF83, A0A805TBS0
  8. NM_001367454.1NP_001354383.1  rho GTPase-activating protein 21 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AL355979, AL392104
    Consensus CDS
    CCDS7144.2
    UniProtKB/Swiss-Prot
    Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
  9. NM_001367455.1NP_001354384.1  rho GTPase-activating protein 21 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL392104
    UniProtKB/TrEMBL
    A0A2X0SF83
    Related
    ENST00000486374.5
  10. NM_020824.4NP_065875.3  rho GTPase-activating protein 21 isoform a

    See identical proteins and their annotated locations for NP_065875.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a).
    Source sequence(s)
    AB037845, AF480466, AL355979, AV709499, BI491305, BQ026288
    Consensus CDS
    CCDS7144.2
    UniProtKB/Swiss-Prot
    Q0VF98, Q5T5U3, Q7Z3P7, Q8N3A2, Q8NI19, Q8TBV5, Q9P2C3
    UniProtKB/TrEMBL
    A0A2X0SF83
    Related
    ENSP00000379709.2, ENST00000396432.7
    Conserved Domains (3) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11441339
    RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    cd01253
    Location:9331042
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain

RNA

  1. NR_160021.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  2. NR_160022.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  3. NR_160023.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355979, AL392104
  4. NR_160024.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL392104
  5. NR_160025.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL392104

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    24583614..24723887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425561.1XP_047281517.1  rho GTPase-activating protein 21 isoform X7

  2. XM_011519605.3XP_011517907.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11681363
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9571066
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9581063
    PH; PH domain
  3. XM_047425560.1XP_047281516.1  rho GTPase-activating protein 21 isoform X6

  4. XM_011519607.3XP_011517909.1  rho GTPase-activating protein 21 isoform X4

    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  5. XM_011519602.3XP_011517904.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517904.1

    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  6. XM_047425562.1XP_047281518.1  rho GTPase-activating protein 21 isoform X7

  7. XM_047425557.1XP_047281513.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
  8. XM_011519604.3XP_011517906.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517906.1

    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  9. XM_047425556.1XP_047281512.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
  10. XM_011519603.4XP_011517905.1  rho GTPase-activating protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011517905.1

    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (4) summary
    cd00992
    Location:48155
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11781373
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:9671076
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9681073
    PH; PH domain
  11. XM_011519606.3XP_011517908.1  rho GTPase-activating protein 21 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SF83
    Conserved Domains (4) summary
    cd00992
    Location:3487
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04395
    Location:11101305
    RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
    cd01253
    Location:8991008
    PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    pfam00169
    Location:9001005
    PH; PH domain
  12. XM_047425563.1XP_047281519.1  rho GTPase-activating protein 21 isoform X8

    UniProtKB/TrEMBL
    A0A1B0GV73
    Related
    ENSP00000490396.1, ENST00000636789.1
  13. XM_047425559.1XP_047281515.1  rho GTPase-activating protein 21 isoform X5

    UniProtKB/TrEMBL
    A0A1B0GV73

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    24602382..24742515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366417.1XP_054222392.1  rho GTPase-activating protein 21 isoform X7

  2. XM_054366410.1XP_054222385.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
  3. XM_054366416.1XP_054222391.1  rho GTPase-activating protein 21 isoform X6

  4. XM_054366414.1XP_054222389.1  rho GTPase-activating protein 21 isoform X4

  5. XM_054366407.1XP_054222382.1  rho GTPase-activating protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SF83
  6. XM_054366418.1XP_054222393.1  rho GTPase-activating protein 21 isoform X7

  7. XM_054366412.1XP_054222387.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
  8. XM_054366409.1XP_054222384.1  rho GTPase-activating protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SF83
  9. XM_054366411.1XP_054222386.1  rho GTPase-activating protein 21 isoform X2

    UniProtKB/TrEMBL
    A0A2X0SF83
  10. XM_054366408.1XP_054222383.1  rho GTPase-activating protein 21 isoform X1

    UniProtKB/TrEMBL
    A0A2X0SF83
  11. XM_054366413.1XP_054222388.1  rho GTPase-activating protein 21 isoform X3

    UniProtKB/TrEMBL
    A0A2X0SF83
  12. XM_054366419.1XP_054222394.1  rho GTPase-activating protein 21 isoform X8

    UniProtKB/TrEMBL
    B7Z3A3
  13. XM_054366415.1XP_054222390.1  rho GTPase-activating protein 21 isoform X5

    UniProtKB/TrEMBL
    B7Z3A3