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ARRDC3 arrestin domain containing 3 [ Homo sapiens (human) ]

Gene ID: 57561, updated on 10-Oct-2019

Summary

Official Symbol
ARRDC3provided by HGNC
Official Full Name
arrestin domain containing 3provided by HGNC
Primary source
HGNC:HGNC:29263
See related
Ensembl:ENSG00000113369 MIM:612464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLIMP
Summary
This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 76.9), thyroid (RPKM 64.6) and 24 other tissues See more
Orthologs

Genomic context

See ARRDC3 in Genome Data Viewer
Location:
5q14.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (91368631..91383332, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (90664541..90679149, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene lung cancer associated transcript 1 Neighboring gene ribosomal protein S18 pseudogene 7 Neighboring gene ARRDC3 antisense RNA 1 Neighboring gene RAB5C, member RAS oncogene family pseudogene 2 Neighboring gene uncharacterized LOC107986434

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Identification of inherited genetic variations influencing prognosis in early-onset breast cancer.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1376

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-3 adrenergic receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
fat pad development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of heat generation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ubiquitin-protein transferase activity IPI
Inferred from Physical Interaction
more info
PubMed 
skin development IEA
Inferred from Electronic Annotation
more info
 
temperature homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arrestin domain-containing protein 3
Names
TBP-2-like inducible membrane protein
alpha-arrestin 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051241.1 RefSeqGene

    Range
    5057..19743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001329670.2NP_001316599.1  arrestin domain-containing protein 3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC008799
  2. NM_001329671.2NP_001316600.1  arrestin domain-containing protein 3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC008799
  3. NM_001329672.2NP_001316601.1  arrestin domain-containing protein 3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: Variants 2, 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AC008799
  4. NM_020801.4NP_065852.1  arrestin domain-containing protein 3 isoform a

    See identical proteins and their annotated locations for NP_065852.1

    Status: REVIEWED

    Source sequence(s)
    AB037797, AC008799, BX642781, HY355442
    Consensus CDS
    CCDS34202.1
    UniProtKB/Swiss-Prot
    Q96B67
    Related
    ENSP00000265138.3, ENST00000265138.4
    Conserved Domains (2) summary
    smart01017
    Location:187314
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:22165
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_138071.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008799
  2. NR_138072.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008799

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    91368631..91383332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956165.1 RNA Sequence

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