U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arrdc3 arrestin domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 105171, updated on 6-Oct-2022

Summary

Official Symbol
Arrdc3provided by MGI
Official Full Name
arrestin domain containing 3provided by MGI
Primary source
MGI:MGI:2145242
See related
Ensembl:ENSMUSG00000074794 AllianceGenome:MGI:2145242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1376
Summary
Predicted to enable beta-3 adrenergic receptor binding activity. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including fat pad development; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway; and negative regulation of locomotion involved in locomotory behavior. Predicted to be located in lysosome and membrane. Predicted to be active in endosome and plasma membrane. Is expressed in central nervous system; liver; lung; olfactory epithelium; and retina nuclear layer. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 18.7), limb E14.5 (RPKM 10.4) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Arrdc3 in Genome Data Viewer
Location:
13; 13 C2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (81031503..81044161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (80883384..80896042)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene Neighboring gene 40S ribosomal protein S8 pseudogene Neighboring gene RIKEN cDNA 5430425K12 gene Neighboring gene predicted gene 4211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • MGC107410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-3 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arrestin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042591.2NP_001036056.1  arrestin domain-containing protein 3

    See identical proteins and their annotated locations for NP_001036056.1

    Status: VALIDATED

    Source sequence(s)
    CT009711
    Consensus CDS
    CCDS36736.1
    UniProtKB/Swiss-Prot
    Q7TPQ9, Q8K0L7
    Related
    ENSMUSP00000096957.3, ENSMUST00000099356.10
    Conserved Domains (2) summary
    smart01017
    Location:187314
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    pfam00339
    Location:22165
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RNA

  1. NR_153410.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009711
    Related
    ENSMUST00000159690.8
  2. NR_153411.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009711

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    81031503..81044161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247082.1XP_030102942.1  arrestin domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E0CZE1
    Conserved Domains (1) summary
    smart01017
    Location:594
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  2. XM_030247081.1XP_030102941.1  arrestin domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    E0CZE1
    Related
    ENSMUSP00000125455.2, ENSMUST00000161441.2
    Conserved Domains (1) summary
    smart01017
    Location:594
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
  3. XM_006517017.4XP_006517080.1  arrestin domain-containing protein 3 isoform X1

    Conserved Domains (2) summary
    smart01017
    Location:96223
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:1374
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178917.2: Suppressed sequence

    Description
    NM_178917.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.