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SERINC1 serine incorporator 1 [ Homo sapiens (human) ]

Gene ID: 57515, updated on 13-Mar-2020

Summary

Official Symbol
SERINC1provided by HGNC
Official Full Name
serine incorporator 1provided by HGNC
Primary source
HGNC:HGNC:13464
See related
Ensembl:ENSG00000111897 MIM:614548
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDE2; TMS2; TDE1L; TMS-2
Expression
Ubiquitous expression in brain (RPKM 241.4), adrenal (RPKM 145.5) and 25 other tissues See more
Orthologs

Genomic context

See SERINC1 in Genome Data Viewer
Location:
6q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (122443351..122471807, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122764493..122793051, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 18, pseudogene Neighboring gene heat shock transcription factor 2 Neighboring gene cAMP-dependent protein kinase inhibitor beta Neighboring gene uncharacterized LOC112267966

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
membrane biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylserine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of serine C-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sphingolipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine incorporator 1
Names
tumor differentially expressed protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020755.4NP_065806.1  serine incorporator 1 precursor

    See identical proteins and their annotated locations for NP_065806.1

    Status: VALIDATED

    Source sequence(s)
    AF087902, AY358429, BC033029
    Consensus CDS
    CCDS5125.1
    UniProtKB/Swiss-Prot
    Q9NRX5
    Related
    ENSP00000342962.3, ENST00000339697.5
    Conserved Domains (1) summary
    pfam03348
    Location:16451
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    122443351..122471807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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