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SERINC1 serine incorporator 1 [ Homo sapiens (human) ]

Gene ID: 57515, updated on 8-Feb-2025

Summary

Official Symbol
SERINC1provided by HGNC
Official Full Name
serine incorporator 1provided by HGNC
Primary source
HGNC:HGNC:13464
See related
Ensembl:ENSG00000111897 MIM:614548; AllianceGenome:HGNC:13464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDE2; TMS2; TDE1L; TMS-2
Summary
Predicted to enable acetyltransferase activator activity; enzyme binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in membrane biogenesis; phosphatidylserine metabolic process; and sphingolipid metabolic process. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Feb 2025]
Expression
Ubiquitous expression in brain (RPKM 241.4), adrenal (RPKM 145.5) and 25 other tissues See more
Orthologs
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Genomic context

See SERINC1 in Genome Data Viewer
Location:
6q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (122443351..122471807, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (123631640..123660124, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122764496..122792952, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 18, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11815 Neighboring gene NANOG hESC enhancer GRCh37_chr6:122714378-122714996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17514 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:122721093-122721592 Neighboring gene heat shock transcription factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25021 Neighboring gene cAMP-dependent protein kinase inhibitor beta Neighboring gene uncharacterized LOC124901391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884400-122884937 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:122884938-122885474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:122932197-122932842 Neighboring gene MPRA-validated peak6076 silencer Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:123017072-123018271 Neighboring gene MPRA-validated peak6077 silencer Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acetyltransferase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in membrane biogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phosphatidylserine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
serine incorporator 1
Names
tumor differentially expressed protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020755.4NP_065806.1  serine incorporator 1

    See identical proteins and their annotated locations for NP_065806.1

    Status: VALIDATED

    Source sequence(s)
    AF087902, AY358429, BC033029
    Consensus CDS
    CCDS5125.1
    UniProtKB/Swiss-Prot
    B3KY69, E1P565, O75655, Q7Z2F5, Q8TAG1, Q9NRX5, Q9NTH8, Q9ULG7
    Related
    ENSP00000342962.3, ENST00000339697.5
    Conserved Domains (1) summary
    pfam03348
    Location:17451
    Serinc; Serine incorporator (Serinc)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    122443351..122471807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    123631640..123660124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)