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ADGRB1 adhesion G protein-coupled receptor B1 [ Homo sapiens (human) ]

Gene ID: 575, updated on 2-Oct-2018

Summary

Official Symbol
ADGRB1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B1provided by HGNC
Primary source
HGNC:HGNC:943
See related
Ensembl:ENSG00000181790 MIM:602682; Vega:OTTHUMG00000164732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI1; GDAIF
Summary
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 8.6), spleen (RPKM 1.3) and 4 other tissues See more
Orthologs

Genomic context

See ADGRB1 in Genome Data Viewer
Location:
8q24.3
Exon count:
33
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (142449703..142545009)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143545377..143626369)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986983 Neighboring gene t-SNARE domain containing 1 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene activity regulated cytoskeleton associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat LRRK2 kinase inhibition suppresses HIV-1 Tat-induced upregulation of phosphatidylserine receptor BAI1 in microglia cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
lipopolysaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis TAS
Traceable Author Statement
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
engulfment of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
phagocytosis, recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor B1
Names
brain-specific angiogenesis inhibitor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001702.2NP_001693.2  adhesion G protein-coupled receptor B1 precursor

    See identical proteins and their annotated locations for NP_001693.2

    Status: REVIEWED

    Source sequence(s)
    AB005297, AC139676
    Consensus CDS
    CCDS64985.1
    UniProtKB/Swiss-Prot
    O14514
    Related
    ENSP00000313046.5, ENST00000323289.6
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9441180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:662857
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    142449703..142545009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013695.1XP_016869184.1  adhesion G protein-coupled receptor B1 isoform X5

  2. XM_017013691.1XP_016869180.1  adhesion G protein-coupled receptor B1 isoform X1

  3. XM_017013692.1XP_016869181.1  adhesion G protein-coupled receptor B1 isoform X2

  4. XM_017013696.1XP_016869185.1  adhesion G protein-coupled receptor B1 isoform X6

  5. XM_017013694.1XP_016869183.1  adhesion G protein-coupled receptor B1 isoform X4

  6. XM_011517199.2XP_011515501.1  adhesion G protein-coupled receptor B1 isoform X8

    See identical proteins and their annotated locations for XP_011515501.1

    UniProtKB/Swiss-Prot
    O14514
    Related
    ENSP00000430945.1, OTTHUMP00000227339, ENST00000517894.5, OTTHUMT00000379963
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9441180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:662857
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
  7. XM_017013693.1XP_016869182.1  adhesion G protein-coupled receptor B1 isoform X3

  8. XM_017013697.1XP_016869186.1  adhesion G protein-coupled receptor B1 isoform X7

  9. XM_011517202.2XP_011515504.1  adhesion G protein-coupled receptor B1 isoform X9

    Related
    ENSP00000427783.1, OTTHUMP00000227746, ENST00000521208.5, OTTHUMT00000380655
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:662857
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:9441139
    7tm_4; Olfactory receptor
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