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ADGRB1 adhesion G protein-coupled receptor B1 [ Homo sapiens (human) ]

Gene ID: 575, updated on 3-Apr-2024

Summary

Official Symbol
ADGRB1provided by HGNC
Official Full Name
adhesion G protein-coupled receptor B1provided by HGNC
Primary source
HGNC:HGNC:943
See related
Ensembl:ENSG00000181790 MIM:602682; AllianceGenome:HGNC:943
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAI1; GDAIF
Summary
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 8.6), spleen (RPKM 1.3) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ADGRB1 in Genome Data Viewer
Location:
8q24.3
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (142449649..142545007)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (143591907..143688308)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (143531010..143626368)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1162 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143283162-143283882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143284603-143285322 Neighboring gene long intergenic non-protein coding RNA 51 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143300684-143301572 Neighboring gene t-SNARE domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143341408-143341908 Neighboring gene RNA, 7SL, cytoplasmic 260, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143375399-143375900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28058 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143419370-143420072 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143424933-143425449 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143425450-143425965 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143436639-143437406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143441158-143441658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143457662-143458237 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143458238-143458812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143477973-143478474 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143484673-143485448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143491197-143491875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143497207-143498198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143498199-143499188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143508526-143509300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143515169-143515669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19598 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143534525-143535456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143535457-143536388 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143545037-143545542 Neighboring gene uncharacterized LOC124902075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143550893-143551634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143551635-143552376 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143553119-143553858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143587077-143587778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143590247-143591018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143591019-143591788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143594079-143594580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143594581-143595080 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143608973-143609474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143626930-143627856 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143636183-143636684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143636685-143637184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143647608-143648108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143653071-143653734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143656141-143656686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:143667160-143667842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143678374-143678876 Neighboring gene maestro heat like repeat family member 4, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143689749-143690476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:143695033-143695931 Neighboring gene activity regulated cytoskeleton associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat LRRK2 kinase inhibition suppresses HIV-1 Tat-induced upregulation of phosphatidylserine receptor BAI1 in microglia cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ41988

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
enables lipopolysaccharide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in engulfment of apoptotic cell IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in engulfment of apoptotic cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in engulfment of apoptotic cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peripheral nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in phagocytosis, recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of myoblast fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
adhesion G protein-coupled receptor B1
Names
brain-specific angiogenesis inhibitor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001391985.1NP_001378914.1  adhesion G protein-coupled receptor B1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC139676
    Consensus CDS
    CCDS94349.1
    UniProtKB/TrEMBL
    A0A2R8Y5M7
    Related
    ENSP00000494563.1, ENST00000643448.1
    Conserved Domains (6) summary
    smart00303
    Location:877935
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:574640
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    cd15990
    Location:9381204
    7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:658856
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:41216
    AGRB_N; Adhesion GPCR B N-terminal region
  2. NM_001391986.1NP_001378915.1  adhesion G protein-coupled receptor B1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC139676
    Conserved Domains (6) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    cd15990
    Location:9411201
    7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam16489
    Location:661859
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    pfam19188
    Location:41216
    AGRB_N; Adhesion GPCR B N-terminal region
  3. NM_001391987.1NP_001378916.1  adhesion G protein-coupled receptor B1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC139676
    Conserved Domains (1) summary
    cd15990
    Location:1267
    7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  4. NM_001391988.1NP_001378917.1  adhesion G protein-coupled receptor B1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC139676
    Conserved Domains (1) summary
    cd15990
    Location:1267
    7tmB2_BAI1; brain-specific angiogenesis inhibitor 1, a group VII adhesion GPCR, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  5. NM_001702.3NP_001693.2  adhesion G protein-coupled receptor B1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001693.2

    Status: REVIEWED

    Source sequence(s)
    AC139676
    Consensus CDS
    CCDS64985.1
    UniProtKB/Swiss-Prot
    O14514
    Related
    ENSP00000430945.1, ENST00000517894.6
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam00002
    Location:9441180
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam16489
    Location:662857
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    142449649..142545007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013695.2XP_016869184.1  adhesion G protein-coupled receptor B1 isoform X6

  2. XM_047422057.1XP_047278013.1  adhesion G protein-coupled receptor B1 isoform X7

  3. XM_017013691.2XP_016869180.1  adhesion G protein-coupled receptor B1 isoform X1

  4. XM_017013692.2XP_016869181.1  adhesion G protein-coupled receptor B1 isoform X2

  5. XM_017013696.2XP_016869185.1  adhesion G protein-coupled receptor B1 isoform X8

  6. XM_047422059.1XP_047278015.1  adhesion G protein-coupled receptor B1 isoform X10

  7. XM_017013694.2XP_016869183.1  adhesion G protein-coupled receptor B1 isoform X4

  8. XM_047422056.1XP_047278012.1  adhesion G protein-coupled receptor B1 isoform X5

  9. XM_047422060.1XP_047278016.1  adhesion G protein-coupled receptor B1 isoform X12

  10. XM_047422058.1XP_047278014.1  adhesion G protein-coupled receptor B1 isoform X9

  11. XM_047422061.1XP_047278017.1  adhesion G protein-coupled receptor B1 isoform X13

  12. XM_017013693.2XP_016869182.1  adhesion G protein-coupled receptor B1 isoform X3

  13. XM_017013697.2XP_016869186.1  adhesion G protein-coupled receptor B1 isoform X11

  14. XM_011517202.3XP_011515504.1  adhesion G protein-coupled receptor B1 isoform X14

    UniProtKB/TrEMBL
    E5RG74
    Related
    ENSP00000427783.1, ENST00000521208.5
    Conserved Domains (5) summary
    smart00303
    Location:880938
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00008
    Location:577643
    HormR; Domain present in hormone receptors
    smart00209
    Location:412462
    TSP1; Thrombospondin type 1 repeats
    pfam16489
    Location:662857
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cl21561
    Location:9441139
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    143591907..143688308
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360930.1XP_054216905.1  adhesion G protein-coupled receptor B1 isoform X6

  2. XM_054360931.1XP_054216906.1  adhesion G protein-coupled receptor B1 isoform X7

  3. XM_054360925.1XP_054216900.1  adhesion G protein-coupled receptor B1 isoform X1

  4. XM_054360926.1XP_054216901.1  adhesion G protein-coupled receptor B1 isoform X2

  5. XM_054360932.1XP_054216907.1  adhesion G protein-coupled receptor B1 isoform X8

  6. XM_054360934.1XP_054216909.1  adhesion G protein-coupled receptor B1 isoform X10

  7. XM_054360928.1XP_054216903.1  adhesion G protein-coupled receptor B1 isoform X4

  8. XM_054360929.1XP_054216904.1  adhesion G protein-coupled receptor B1 isoform X5

  9. XM_054360936.1XP_054216911.1  adhesion G protein-coupled receptor B1 isoform X12

  10. XM_054360933.1XP_054216908.1  adhesion G protein-coupled receptor B1 isoform X9

  11. XM_054360937.1XP_054216912.1  adhesion G protein-coupled receptor B1 isoform X13

  12. XM_054360927.1XP_054216902.1  adhesion G protein-coupled receptor B1 isoform X3

  13. XM_054360935.1XP_054216910.1  adhesion G protein-coupled receptor B1 isoform X11

  14. XM_054360938.1XP_054216913.1  adhesion G protein-coupled receptor B1 isoform X14