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Plin4 perilipin 4 [ Mus musculus (house mouse) ]

Gene ID: 57435, updated on 2-Nov-2024

Summary

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Official Symbol
Plin4provided by MGI
Official Full Name
perilipin 4provided by MGI
Primary source
MGI:MGI:1929709
See related
Ensembl:ENSMUSG00000002831 AllianceGenome:MGI:1929709
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
S3-12; mKIAA1881
Summary
Located in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human PLIN4 (perilipin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 471.2), genital fat pad adult (RPKM 371.8) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Plin4 in Genome Data Viewer
Location:
17 29.16 cM; 17 D
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56407587..56416947, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56100587..56109948, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chromatin assembly factor 1, subunit A Neighboring gene UBX domain protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E100 Neighboring gene HDGF like 2 Neighboring gene nuclear encoded tRNA glutamic acid 4 (anticodon CTC) Neighboring gene perilipin 5 Neighboring gene leucine-rich alpha-2-glycoprotein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells. Zhang XD, et al. Redox Biol, 2024 Oct. PMID 39173539, Free PMC Article
  2. Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis. Zhu L, et al. Mol Neurobiol, 2021 Apr. PMID 33242187
  3. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. Pei J, et al. J Biol Chem, 2024 Jun. PMID 38677512, Free PMC Article
  4. Adipocyte protein S3-12 coats nascent lipid droplets. Wolins NE, et al. J Biol Chem, 2003 Sep 26. PMID 12840023
  5. Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Scherer PE, et al. Nat Biotechnol, 1998 Jun. PMID 9624692

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells.
    Title: Plin4 exacerbates cadmium-decreased testosterone level via inducing ferroptosis in testicular Leydig cells.
  2. Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
    Title: Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation.
  3. Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis.
    Title: Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis.
  4. Loss of Plin4 has no effect on body weight or composition or on adipose mass or development. Triacylglycerol (TAG) content in the heart is markedly reduced. The heart of Plin4(-/-) mice displays reduced Plin5 mRNA and protein levels.
    Title: Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice.
  5. Direct regulation of perilipin and S3-12 by PPAR-gamma may to be important mediator of prolonged treatment with PPAR-gamma activators: insulin sensitization, fatty acid trapping in adipose tissue, reduced basal adipose lipolysis, and weight gain.
    Title: Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.
  6. Adipocyte protein S3-12 coats nascent lipid droplets.
    Title: Adipocyte protein S3-12 coats nascent lipid droplets.
  7. the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess
    Title: S3-12, Adipophilin, and TIP47 package lipid in adipocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
perilipin-4
Names
adipocyte protein S3-12
plasma membrane associated protein, S3-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372234.1 → NP_001359163.1  perilipin-4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009719
    Consensus CDS
    CCDS89124.1
    UniProtKB/TrEMBL
    A0A571BEC9
    Related
    ENSMUSP00000158677.2, ENSMUST00000238734.2
    Conserved Domains (2) summary
    cl28536
    Location:782 → 1316
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1351 → 1582
    Perilipin; Perilipin family

  2. NM_001410163.1 → NP_001397092.1  perilipin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT009719

  3. NM_001410164.1 → NP_001397093.1  perilipin-4 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT009719

  4. NM_001410165.1 → NP_001397094.1  perilipin-4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CT009719

  5. NM_001410166.1 → NP_001397095.1  perilipin-4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CT009719

  6. NM_001410167.1 → NP_001397096.1  perilipin-4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CT009719

  7. NM_001410168.1 → NP_001397097.1  perilipin-4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    CT009719

  8. NM_001410172.1 → NP_001397101.1  perilipin-4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CT009719

  9. NM_001410173.1 → NP_001397102.1  perilipin-4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT009719

  10. NM_001410174.1 → NP_001397103.1  perilipin-4 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CT009719

  11. NM_001410175.1 → NP_001397104.1  perilipin-4 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CT009719

  12. NM_020568.4 → NP_065593.2  perilipin-4 isoform 2

    See identical proteins and their annotated locations for NP_065593.2

    Status: VALIDATED

    Source sequence(s)
    CT009719
    Consensus CDS
    CCDS79565.1
    UniProtKB/Swiss-Prot
    E9QN72, O88492, Q69Z80, Q8BNV5
    Related
    ENSMUSP00000139859.2, ENSMUST00000190703.7
    Conserved Domains (2) summary
    cl28536
    Location:584 → 1118
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1153 → 1384
    Perilipin; Perilipin family

RNA

  1. NR_176959.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009719

  2. NR_176960.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CT009719

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    56407587..56416947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246549.4 → XP_011244851.1  perilipin-4 isoform X5

    See identical proteins and their annotated locations for XP_011244851.1

    Conserved Domains (2) summary
    cl28536
    Location:693 → 1227
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1262 → 1519
    Perilipin; Perilipin family

  2. XM_036160710.1 → XP_036016603.1  perilipin-4 isoform X9

    Conserved Domains (2) summary
    cl28536
    Location:782 → 1316
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1351 → 1466
    Perilipin; Perilipin family

  3. XM_011246548.4 → XP_011244850.1  perilipin-4 isoform X4

    Conserved Domains (2) summary
    cl28536
    Location:118 → 466
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1274 → 1531
    Perilipin; Perilipin family

  4. XM_017317591.3 → XP_017173080.1  perilipin-4 isoform X8

    Conserved Domains (2) summary
    cl28536
    Location:804 → 1338
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1373 → 1485
    Perilipin; Perilipin family

  5. XM_011246551.4 → XP_011244853.1  perilipin-4 isoform X7

    Conserved Domains (2) summary
    cl28536
    Location:804 → 1338
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1373 → 1490
    Perilipin; Perilipin family

  6. XM_011246550.3 → XP_011244852.1  perilipin-4 isoform X5

    See identical proteins and their annotated locations for XP_011244852.1

    Conserved Domains (2) summary
    cl28536
    Location:693 → 1227
    COG5412; Phage-related protein [Mobilome: prophages, transposons]
    pfam03036
    Location:1262 → 1519
    Perilipin; Perilipin family

RNA

  1. XR_004939565.1 RNA Sequence

  2. XR_004939564.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88492.2 GenPept UniProtKB/Swiss-Prot:O88492

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