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PLIN4 perilipin 4 [ Homo sapiens (human) ]

Gene ID: 729359, updated on 13-Mar-2020

Summary

Official Symbol
PLIN4provided by HGNC
Official Full Name
perilipin 4provided by HGNC
Primary source
HGNC:HGNC:29393
See related
Ensembl:ENSG00000167676 MIM:613247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S3-12; KIAA1881
Summary
Members of the perilipin family, such as PLIN4, coat intracellular lipid storage droplets (Wolins et al., 2003 [PubMed 12840023]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in fat (RPKM 510.0) and heart (RPKM 14.4) See more
Orthologs

Genomic context

See PLIN4 in Genome Data Viewer
Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (4502192..4520285, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (4502192..4518529, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985297 Neighboring gene chromatin assembly factor 1 subunit A Neighboring gene microRNA 4746 Neighboring gene UBX domain protein 6 Neighboring gene HDGF like 2 Neighboring gene perilipin 5 Neighboring gene leucine rich alpha-2-glycoprotein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1881

Gene Ontology Provided by GOA

Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
perilipin-4
Names
adipocyte protein S3-12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367868.2NP_001354797.1  perilipin-4

    Status: VALIDATED

    Source sequence(s)
    AC011498
    Related
    ENSP00000301286.3, ENST00000301286.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    4502192..4520285 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027193.1XP_016882682.1  perilipin-4 isoform X1

  2. XM_017027194.1XP_016882683.1  perilipin-4 isoform X1

  3. XM_011528233.2XP_011526535.1  perilipin-4 isoform X2

    See identical proteins and their annotated locations for XP_011526535.1

    Conserved Domains (1) summary
    pfam03036
    Location:10131415
    Perilipin; Perilipin family
  4. XM_017027192.1XP_016882681.1  perilipin-4 isoform X1

  5. XM_006722866.2XP_006722929.1  perilipin-4 isoform X3

    UniProtKB/TrEMBL
    A0A0J9YXN7
    Related
    ENSP00000488481.1, ENST00000633942.1
    Conserved Domains (1) summary
    pfam03036
    Location:9531355
    Perilipin; Perilipin family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080400.1: Suppressed sequence

    Description
    NM_001080400.1: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
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