Format

Send to:

Choose Destination

CLLU1 chronic lymphocytic leukemia up-regulated 1 [ Homo sapiens (human) ]

Gene ID: 574028, updated on 25-Jan-2022

Summary

Official Symbol
CLLU1provided by HGNC
Official Full Name
chronic lymphocytic leukemia up-regulated 1provided by HGNC
Primary source
HGNC:HGNC:29841
See related
Ensembl:ENSG00000257127 MIM:616988; AllianceGenome:HGNC:29841
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Expression of this gene has been shown to be upregulated in some individuals with chronic lymphocytic leukemia (CLL), and has been used for prognostic and diagnostic purposes. This gene was originally identified as a human-specific putative protein-coding gene due to the presence of a peptide (PAp00140670, HIIYSTFLSK) that could have supported translation at this locus. This peptide is not present in more recent builds of PeptideAtlas, and the presence of a protein product at this locus has not been independently verified. For this reason, this gene is being represented as non-coding. Sequence comparisons to other primates indicates that no other primate is predicted to contain an open reading frame. [provided by RefSeq, Feb 2017]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CLLU1 in Genome Data Viewer
Location:
12q22
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (92421531..92431002)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (92815307..92824778)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr12.2880 Neighboring gene CRISPRi-validated cis-regulatory element chr12.2881 Neighboring gene CLLU1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 2397 Neighboring gene uncharacterized LOC105369904

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Other Names

  • chronic lymphocytic leukemia up-regulated protein 1

Clone Names

  • MGC173218, MGC180158

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_027932.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript.
    Source sequence(s)
    AJ845162, AJ845163
    Related
    ENST00000472839.6
  2. NR_027933.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal exon, compared to variant 2.
    Source sequence(s)
    AJ845162
    Related
    ENST00000512817.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    92421531..92431002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025233.2: Suppressed sequence

    Description
    NM_001025233.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Support Center