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PTGFR prostaglandin F receptor [ Homo sapiens (human) ]

Gene ID: 5737, updated on 1-Aug-2020

Summary

Official Symbol
PTGFRprovided by HGNC
Official Full Name
prostaglandin F receptorprovided by HGNC
Primary source
HGNC:HGNC:9600
See related
Ensembl:ENSG00000122420 MIM:600563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP
Summary
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues See more
Orthologs

Genomic context

See PTGFR in Genome Data Viewer
Location:
1p31.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (78490974..78540701)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78956728..79006386)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized MGC27382 Neighboring gene RNA, 5S ribosomal pseudogene 23 Neighboring gene interferon induced protein 44 like Neighboring gene interferon induced protein 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
NHGRI GWA Catalog
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46203, MGC120498

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin F receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin F receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-mediated signaling using intracellular calcium source IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to prostaglandin D stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
parturition TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin F2-alpha receptor
Names
FP prostanoid receptor
PGF receptor
PGF2 alpha receptor
prostaglandin receptor (2-alpha)
prostanoid FP receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052997.1 RefSeqGene

    Range
    5001..54728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000959.4NP_000950.1  prostaglandin F2-alpha receptor isoform a precursor

    See identical proteins and their annotated locations for NP_000950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL136324, BC112965
    Consensus CDS
    CCDS686.1
    UniProtKB/Swiss-Prot
    P43088
    Related
    ENSP00000359793.3, ENST00000370757.8
    Conserved Domains (1) summary
    cd15145
    Location:27316
    7tmA_FP; prostaglandin F2-alpha receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001039585.2NP_001034674.1  prostaglandin F2-alpha receptor isoform b precursor

    See identical proteins and their annotated locations for NP_001034674.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL136324, BC112965, CD013876
    Consensus CDS
    CCDS30759.1
    UniProtKB/Swiss-Prot
    P43088
    Related
    ENSP00000359792.3, ENST00000370756.3
    Conserved Domains (1) summary
    pfam00001
    Location:44291
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    78490974..78540701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001873.1XP_016857362.1  prostaglandin F2-alpha receptor isoform X1

    UniProtKB/Swiss-Prot
    P43088

RNA

  1. XR_001737338.1 RNA Sequence

  2. XR_946715.2 RNA Sequence

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