Format

Send to:

Choose Destination

PTGER3 prostaglandin E receptor 3 [ Homo sapiens (human) ]

Gene ID: 5733, updated on 10-May-2020

Summary

Official Symbol
PTGER3provided by HGNC
Official Full Name
prostaglandin E receptor 3provided by HGNC
Primary source
HGNC:HGNC:9595
See related
Ensembl:ENSG00000050628 MIM:176806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues See more
Orthologs

Genomic context

See PTGER3 in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (70852358..71047816, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71318036..71513497, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.6877 Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene uncharacterized LOC102724572 Neighboring gene uncharacterized LOC107985517 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 antisense RNA 2 (head to head) Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27302, MGC141828, MGC141829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
prostaglandin E receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell death TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intestine smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of fever generation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP3 subtype
Names
PGE receptor, EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receotor EP3 subtype 3 isoform
prostaglandin E receptor 3 (subtype EP3)
prostaglandin receptor (PGE-2)
prostanoid EP3 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029509.2 RefSeqGene

    Range
    4993..200451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126044.2NP_001119516.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_001119516.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, S69326
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    P43115
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_198714.2NP_942007.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942007.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D38298, X83861, X83863
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000359969.3, ENST00000370931.7
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_198715.3NP_942008.1  prostaglandin E2 receptor EP3 subtype isoform 5

    See identical proteins and their annotated locations for NP_942008.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, D38299
    Consensus CDS
    CCDS658.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000359962.3, ENST00000370924.4
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_198716.2NP_942009.1  prostaglandin E2 receptor EP3 subtype isoform 6

    See identical proteins and their annotated locations for NP_942009.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, BC024229, X83861, X83863
    Consensus CDS
    CCDS652.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000418073.1, ENST00000460330.5
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  5. NM_198717.2NP_942010.1  prostaglandin E2 receptor EP3 subtype isoform 7

    See identical proteins and their annotated locations for NP_942010.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D38301, X83861, X83863
    Consensus CDS
    CCDS44160.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000486617.1, ENST00000628037.2
    Conserved Domains (1) summary
    cd15146
    Location:49358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
  6. NM_198718.2NP_942011.1  prostaglandin E2 receptor EP3 subtype isoform 8

    See identical proteins and their annotated locations for NP_942011.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, D86097, X83862
    Consensus CDS
    CCDS655.1
    UniProtKB/Swiss-Prot
    P43115
    UniProtKB/TrEMBL
    O00325
    Related
    ENSP00000349003.4, ENST00000356595.8
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. NM_198719.2NP_942012.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942012.1

    Status: REVIEWED

    Source sequence(s)
    AI273491, AL031429, D38297
    Consensus CDS
    CCDS657.1
    UniProtKB/Swiss-Prot
    P43115
    Related
    ENSP00000302313.5, ENST00000306666.9
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_028292.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86097
    Related
    ENST00000361210.6
  2. NR_028293.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86098
    Related
    ENST00000479353.5
  3. NR_028294.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86097, X83863
    Related
    ENST00000497146.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    70852358..71047816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541810.3XP_011540112.1  prostaglandin E2 receptor EP3 subtype isoform X1

    Related
    ENSP00000280208.8, ENST00000351052.9
    Conserved Domains (1) summary
    pfam00001
    Location:65346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_946714.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_000957.2: Suppressed sequence

    Description
    NM_000957.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_198712.2: Suppressed sequence

    Description
    NM_198712.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_198713.1: Suppressed sequence

    Description
    NM_198713.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  4. NM_198720.1: Suppressed sequence

    Description
    NM_198720.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center