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PTGER3 prostaglandin E receptor 3 [ Homo sapiens (human) ]

Gene ID: 5733, updated on 3-May-2025
Official Symbol
PTGER3provided by HGNC
Official Full Name
prostaglandin E receptor 3provided by HGNC
Primary source
HGNC:HGNC:9595
See related
Ensembl:ENSG00000050628 MIM:176806; AllianceGenome:HGNC:9595
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875
Summary
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Expression
Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues See more
Orthologs
mouse all
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See PTGER3 in Genome Data Viewer
Location:
1p31.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (70852358..71047816, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70730386..70925810, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71318041..71513499, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.6877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1197 Neighboring gene caspase 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene MPRA-validated peak284 silencer Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Induction of neutrophil death resembling neither apoptosis nor necrosis by ONO-AE-248, a selective agonist for PGE2 receptor subtype 3. Liu J, et al. J Leukoc Biol, 2000 Aug. PMID 10947062
  2. The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE(2)- and retaining PGE(1)-mediated signaling in live cells. Akasaka H, et al. Arch Biochem Biophys, 2017 Feb 15. PMID 28065721
  3. PGE(2)-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease. Maingret V, et al. Neurobiol Aging, 2017 Feb. PMID 27837675
  4. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. Han X, et al. J Cereb Blood Flow Metab, 2016 Jun. PMID 26661165, Free PMC Article
  5. Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype. Chang C, et al. Biochem J, 1997 Mar 1. PMID 9065782, Free PMC Article

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.
    Title: PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.
  2. E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.
    Title: E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.
  3. Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
    Title: Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
  4. PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
    Title: PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
  5. Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.
    Title: Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.
  6. Prostaglandin E2 EP receptors in cardiovascular disease: An update.
    Title: Prostaglandin E2 EP receptors in cardiovascular disease: An update.
  7. EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
    Title: EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
  8. EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages.
    Title: Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).
  9. These results suggest that PGE2 regulates human brain endothelial cell migration via cooperation of EP2, EP3, and EP4 receptors.
    Title: PGE(2) -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.
  10. Prostaglandin E2 -EP3 receptor subtype gene deletion in mother and son impairs platelet aggregation.
    Title: Prostaglandin E(2) -EP(3) receptor subtype gene deletion in mother and son impairs platelet aggregation.
Submit: New GeneRIF Correction See all GeneRIFs (82)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC27302, MGC141828, MGC141829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prostaglandin E receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables prostaglandin E receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables prostaglandin E receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables prostaglandin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell death TAS
Traceable Author Statement
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intestine smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of fever generation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
prostaglandin E2 receptor EP3 subtype
Names
PGE receptor, EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor 3 (subtype EP3)
prostaglandin receptor (PGE-2)
prostanoid EP3 receptor

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029509.2 RefSeqGene

    Range
    4993..82027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126044.2 → NP_001119516.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_001119516.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, S69326
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
    UniProtKB/TrEMBL
    A8K3L9
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_198714.2 → NP_942007.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942007.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D38298, X83861, X83863
    Consensus CDS
    CCDS656.1
    UniProtKB/Swiss-Prot
    B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
    UniProtKB/TrEMBL
    A8K3L9
    Related
    ENSP00000359969.3, ENST00000370931.7
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_198715.3 → NP_942008.1  prostaglandin E2 receptor EP3 subtype isoform 5

    See identical proteins and their annotated locations for NP_942008.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, D38299
    Consensus CDS
    CCDS658.1
    UniProtKB/TrEMBL
    Q6TTN3
    Related
    ENSP00000359962.3, ENST00000370924.5
    Conserved Domains (1) summary
    cd15146
    Location:49 → 358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_198716.2 → NP_942009.1  prostaglandin E2 receptor EP3 subtype isoform 6

    See identical proteins and their annotated locations for NP_942009.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, BC024229, X83861, X83863
    Consensus CDS
    CCDS652.1
    UniProtKB/TrEMBL
    Q6TTN3
    Related
    ENSP00000418073.1, ENST00000460330.5
    Conserved Domains (1) summary
    cd15146
    Location:49 → 358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

  5. NM_198717.2 → NP_942010.1  prostaglandin E2 receptor EP3 subtype isoform 7

    See identical proteins and their annotated locations for NP_942010.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D38301, X83861, X83863
    Consensus CDS
    CCDS44160.1
    UniProtKB/TrEMBL
    Q6TTN3
    Related
    ENSP00000486617.1, ENST00000628037.2
    Conserved Domains (1) summary
    cd15146
    Location:49 → 358
    7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

  6. NM_198718.2 → NP_942011.1  prostaglandin E2 receptor EP3 subtype isoform 8

    See identical proteins and their annotated locations for NP_942011.1

    Status: REVIEWED

    Source sequence(s)
    AL031429, D86097, X83862
    Consensus CDS
    CCDS655.1
    UniProtKB/TrEMBL
    Q6TTN3
    Related
    ENSP00000349003.4, ENST00000356595.8
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  7. NM_198719.2 → NP_942012.1  prostaglandin E2 receptor EP3 subtype isoform 4

    See identical proteins and their annotated locations for NP_942012.1

    Status: REVIEWED

    Source sequence(s)
    AI273491, AL031429, D38297
    Consensus CDS
    CCDS657.1
    UniProtKB/Swiss-Prot
    B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
    UniProtKB/TrEMBL
    A8K3L9
    Related
    ENSP00000302313.5, ENST00000306666.10
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. NR_028292.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86097
    Related
    ENST00000361210.6

  2. NR_028293.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86098
    Related
    ENST00000479353.5

  3. NR_028294.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL031429, AL158087, D86097, X83863
    Related
    ENST00000497146.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    70852358..71047816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541810.4 → XP_011540112.1  prostaglandin E2 receptor EP3 subtype isoform X1

    UniProtKB/TrEMBL
    A8K3L9
    Conserved Domains (1) summary
    pfam00001
    Location:65 → 346
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_946714.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    70730386..70925810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054337808.1 → XP_054193783.1  prostaglandin E2 receptor EP3 subtype isoform X1

    UniProtKB/TrEMBL
    A8K3L9

RNA

  1. XR_008486118.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_000957.2: Suppressed sequence

    Description
    NM_000957.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_198712.2: Suppressed sequence

    Description
    NM_198712.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  3. NM_198713.1: Suppressed sequence

    Description
    NM_198713.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  4. NM_198720.1: Suppressed sequence

    Description
    NM_198720.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43115.1 GenPept UniProtKB/Swiss-Prot:P43115

Gene LinkOut

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