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Ptger3 prostaglandin E receptor 3 (subtype EP3) [ Mus musculus (house mouse) ]

Gene ID: 19218, updated on 1-Mar-2024

Summary

Official Symbol
Ptger3provided by MGI
Official Full Name
prostaglandin E receptor 3 (subtype EP3)provided by MGI
Primary source
MGI:MGI:97795
See related
Ensembl:ENSMUSG00000040016 AllianceGenome:MGI:97795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EP3; Pgerep3; Ptgerep3
Summary
Enables prostaglandin E receptor activity. Involved in positive regulation of fever generation. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; bicarbonate transport; and fever generation. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 43.5), adrenal adult (RPKM 43.0) and 11 other tissues See more
Orthologs
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Genomic context

See Ptger3 in Genome Data Viewer
Location:
3 H4; 3 81.32 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (157272459..157350392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (157566821..157644758)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930592C13 gene Neighboring gene STARR-seq mESC enhancer starr_09372 Neighboring gene zinc finger, RAN-binding domain containing 2 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157228208-157228509 Neighboring gene microRNA 186 Neighboring gene STARR-seq mESC enhancer starr_09373 Neighboring gene STARR-seq mESC enhancer starr_09375 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:157279973-157280264 Neighboring gene STARR-seq mESC enhancer starr_09378 Neighboring gene STARR-seq mESC enhancer starr_09380 Neighboring gene predicted gene 5550 Neighboring gene STARR-positive B cell enhancer mm9_chr3:157539858-157540158 Neighboring gene predicted gene 6520

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables prostaglandin E receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables prostaglandin E receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables prostaglandin E receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables prostaglandin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within bicarbonate transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fever generation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intestine smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intestine smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of circadian sleep/wake cycle, wakefulness ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gastric acid secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of gastrin-induced gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of colon smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fever generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gastric mucosal blood circulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inhibitory G protein-coupled receptor phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myofibroblast contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil extravasation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction involved in micturition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of circadian sleep/wake cycle, wakefulness ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of norepinephrine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in urinary bladder smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in proximal neuron projection ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP3 subtype
Names
PGE receptor EP3 subtype
PGE2 receptor EP3 subtype
prostaglandin E receptor EP3 subtype
prostanoid EP3 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359745.2NP_001346674.1  prostaglandin E2 receptor EP3 subtype isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132240, AC141480
    Consensus CDS
    CCDS89716.1
    UniProtKB/Swiss-Prot
    P30557
    UniProtKB/TrEMBL
    G3UYL9
    Related
    ENSMUSP00000134137.2, ENSMUST00000173533.2
    Conserved Domains (2) summary
    cd14964
    Location:2852
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:26335
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_011196.4NP_035326.2  prostaglandin E2 receptor EP3 subtype isoform 2

    See identical proteins and their annotated locations for NP_035326.2

    Status: VALIDATED

    Source sequence(s)
    AC132240, AC141480
    Consensus CDS
    CCDS17932.1
    UniProtKB/Swiss-Prot
    P30557
    UniProtKB/TrEMBL
    Q6PDF2
    Related
    ENSMUSP00000043302.7, ENSMUST00000041175.13
    Conserved Domains (1) summary
    pfam00001
    Location:42323
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    157272459..157350392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501140.4XP_006501203.1  prostaglandin E2 receptor EP3 subtype isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:2753
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:26278
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_011240038.3XP_011238340.1  prostaglandin E2 receptor EP3 subtype isoform X1

    UniProtKB/Swiss-Prot
    P30557
    Conserved Domains (2) summary
    cd14964
    Location:2753
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:26298
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily