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PTGER2 prostaglandin E receptor 2 [ Homo sapiens (human) ]

Gene ID: 5732, updated on 13-Jan-2020

Summary

Official Symbol
PTGER2provided by HGNC
Official Full Name
prostaglandin E receptor 2provided by HGNC
Primary source
HGNC:HGNC:9594
See related
Ensembl:ENSG00000125384 MIM:176804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EP2
Summary
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Expression
Broad expression in bone marrow (RPKM 14.8), stomach (RPKM 7.9) and 19 other tissues See more
Orthologs

Genomic context

See PTGER2 in Genome Data Viewer
Location:
14q22.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (52314312..52328598)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (52781016..52795324)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene pumilio domain-containing protein KIAA0020-like Neighboring gene prostaglandin D2 receptor Neighboring gene thioredoxin domain containing 16 Neighboring gene G protein-coupled receptor 137C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of prostaglandin E receptor 2 (PTGER2) in human primary T cells PubMed
capsid gag Prostaglandin E2 downregulates HIV-1 CA/p24 production through the EP2 and EP4 receptors PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
prostaglandin E receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to prostaglandin E stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to prostaglandin E stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of gastric mucosal blood circulation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
prostaglandin E2 receptor EP2 subtype
Names
PGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kD
prostaglandin E receptor 2 (subtype EP2), 53kDa
prostanoid EP2 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013082.1 RefSeqGene

    Range
    5015..19301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000956.4NP_000947.2  prostaglandin E2 receptor EP2 subtype

    See identical proteins and their annotated locations for NP_000947.2

    Status: REVIEWED

    Source sequence(s)
    BC093927, BE739744, BM986745, CF132756, CN484094, CR977661, U19487
    Consensus CDS
    CCDS9708.1
    UniProtKB/Swiss-Prot
    P43116
    Related
    ENSP00000245457.5, ENST00000245457.6
    Conserved Domains (1) summary
    pfam00001
    Location:38314
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    52314312..52328598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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