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Fzd2 frizzled class receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 57265, updated on 2-Apr-2024

Summary

Official Symbol
Fzd2provided by MGI
Official Full Name
frizzled class receptor 2provided by MGI
Primary source
MGI:MGI:1888513
See related
Ensembl:ENSMUSG00000050288 AllianceGenome:MGI:1888513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fz10; Fzd10; Mfz10; Mfz10a
Summary
Enables Wnt-activated receptor activity. Acts upstream of or within several processes, including animal organ morphogenesis; hard palate development; and nervous system development. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Fzd2 in Genome Data Viewer
Location:
11 E1; 11 66.45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102495257..102498884)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102604431..102608058)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene G patch domain containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E10716 Neighboring gene predicted gene, 25337 Neighboring gene STARR-seq mESC enhancer starr_30813 Neighboring gene predicted gene 11627 Neighboring gene RIKEN cDNA 2810433D01 gene Neighboring gene proteasome (prosome, macropain) subunit, beta type 5, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Wnt receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Wnt receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway, calcium modulating pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within endothelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endothelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hard palate development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hard palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within membranous septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within outflow tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ventricular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
frizzled-2
Names
frizzled homolog 2
frizzled-10
fz-10
fz-2
mFz2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020510.2NP_065256.1  frizzled-2 precursor

    See identical proteins and their annotated locations for NP_065256.1

    Status: VALIDATED

    Source sequence(s)
    AL672269, BC055727, CB527017
    Consensus CDS
    CCDS25501.1
    UniProtKB/Swiss-Prot
    Q810M0, Q9JIP5, Q9JIP6, Q9WUJ2
    Related
    ENSMUSP00000091463.5, ENSMUST00000057893.7
    Conserved Domains (2) summary
    cd07464
    Location:40166
    CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
    pfam01534
    Location:240557
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    102495257..102498884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)