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FZD2 frizzled class receptor 2 [ Homo sapiens (human) ]

Gene ID: 2535, updated on 1-Aug-2020

Summary

Official Symbol
FZD2provided by HGNC
Official Full Name
frizzled class receptor 2provided by HGNC
Primary source
HGNC:HGNC:4040
See related
Ensembl:ENSG00000180340 MIM:600667
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fz2; fz-2; fzE2; hFz2; OMOD2
Summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways. [provided by RefSeq, Dec 2010]
Orthologs

Genomic context

See FZD2 in Genome Data Viewer
Location:
17q21.31
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (44557484..44561262)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42634812..42638630)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene G-patch domain containing 8 Neighboring gene RNA, 7SL, cytoplasmic 258, pseudogene Neighboring gene uncharacterized LOC105371791 Neighboring gene long intergenic non-protein coding RNA 1180 Neighboring gene single-pass membrane protein with coiled-coil domains 4 pseudogene 1 Neighboring gene meiosis specific with coiled-coil domain

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cochlea morphogenesis IEA
Inferred from Electronic Annotation
more info
 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
hard palate development IEA
Inferred from Electronic Annotation
more info
 
inner ear receptor cell development IEA
Inferred from Electronic Annotation
more info
 
membranous septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
muscular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
planar cell polarity pathway involved in neural tube closure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
clathrin-coated endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion HDA PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
frizzled-2
Names
frizzled 2, seven transmembrane spanning receptor
frizzled family receptor 2
frizzled homolog 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001466.4NP_001457.1  frizzled-2 precursor

    See identical proteins and their annotated locations for NP_001457.1

    Status: REVIEWED

    Source sequence(s)
    AC103703, AI376463, AW023425, BC052266
    Consensus CDS
    CCDS11484.1
    UniProtKB/Swiss-Prot
    Q14332
    UniProtKB/TrEMBL
    Q86UZ8
    Related
    ENSP00000323901.3, ENST00000315323.5
    Conserved Domains (2) summary
    cd07464
    Location:35161
    CRD_FZ2; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 2 (Fz2) receptor
    cd15245
    Location:234563
    7tmF_FZD2; class F frizzled subfamily 2, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    44557484..44561262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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