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Retn resistin [ Mus musculus (house mouse) ]

Gene ID: 57264, updated on 18-Dec-2022

Summary

Official Symbol
Retnprovided by MGI
Official Full Name
resistinprovided by MGI
Primary source
MGI:MGI:1888506
See related
Ensembl:ENSMUSG00000012705 AllianceGenome:MGI:1888506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ADSF; Rstn; Xcp4; Fizz3
Summary
Predicted to enable hormone activity. Predicted to be involved in several processes, including positive regulation of cell communication; positive regulation of smooth muscle cell migration; and positive regulation of smooth muscle cell proliferation. Located in extracellular space. Is expressed in adipose tissue; gonadal fat pad; inguinal fat pad; renal fat pad; and white fat. Human ortholog(s) of this gene implicated in hypertension; hypertrophic cardiomyopathy; obesity; and type 2 diabetes mellitus. Orthologous to human RETN (resistin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 408.3), mammary gland adult (RPKM 151.5) and 2 other tissues See more
Orthologs
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Genomic context

See Retn in Genome Data Viewer
Location:
8 A1.1; 8 1.92 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3705770..3709818)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3655770..3659818)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene PET100 homolog Neighboring gene Purkinje cell protein 2 (L7) Neighboring gene syntaxin binding protein 2 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Foxo1 corepressor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
resistin
Names
adipose tissue-specific secretory factor
adipose-specific cysteine-rich secreted protein A12-alpha
cysteine-rich secreted protein FIZZ3
dominant inhibitory adipocyte-specific secretory factor
found in inflammatory zone 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204959.1NP_001191888.1  resistin precursor

    See identical proteins and their annotated locations for NP_001191888.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK131613, BC051196
    Consensus CDS
    CCDS22068.1
    UniProtKB/Swiss-Prot
    Q99P87
    UniProtKB/TrEMBL
    A0A8C6GTK0, Q5BMX4
    Related
    ENSMUSP00000012849.9, ENSMUST00000012849.15
    Conserved Domains (1) summary
    pfam06954
    Location:26110
    Resistin
  2. NM_022984.4NP_075360.1  resistin precursor

    See identical proteins and their annotated locations for NP_075360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF510100
    Consensus CDS
    CCDS22068.1
    UniProtKB/Swiss-Prot
    Q99P87
    UniProtKB/TrEMBL
    A0A8C6GTK0, Q5BMX4
    Related
    ENSMUSP00000133024.3, ENSMUST00000169234.3
    Conserved Domains (1) summary
    pfam06954
    Location:26110
    Resistin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    3705770..3709818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)