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RETN resistin [ Homo sapiens (human) ]

Gene ID: 56729, updated on 11-Nov-2018

Summary

Official Symbol
RETNprovided by HGNC
Official Full Name
resistinprovided by HGNC
Primary source
HGNC:HGNC:20389
See related
Ensembl:ENSG00000104918 MIM:605565; Vega:OTTHUMG00000182503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADSF; RSTN; XCP1; FIZZ3; RETN1
Summary
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Biased expression in bone marrow (RPKM 57.7) and lung (RPKM 6.4) See more
Orthologs

Genomic context

See RETN in Genome Data Viewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (7669086..7670454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7733972..7735340)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 2 Neighboring gene ribosomal protein S27a pseudogene 19 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene trafficking protein particle complex 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.
NHGRI GWA Catalog
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
NHGRI GWA Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of resistin (RETN) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126603, MGC126609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of progesterone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
specific granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
resistin
Names
C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
adipose tissue-specific secretory factor
c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
cysteine-rich secreted protein A12-alpha-like 2
cysteine-rich secreted protein FIZZ3
found in inflammatory zone 3
resistin delta2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023447.1 RefSeqGene

    Range
    5001..6369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193374.1NP_001180303.1  resistin precursor

    See identical proteins and their annotated locations for NP_001180303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY207314
    Consensus CDS
    CCDS12182.1
    UniProtKB/Swiss-Prot
    Q9HD89
    Conserved Domains (1) summary
    pfam06954
    Location:20106
    Resistin; Resistin
  2. NM_020415.3NP_065148.1  resistin precursor

    See identical proteins and their annotated locations for NP_065148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF205952, BC069302
    Consensus CDS
    CCDS12182.1
    UniProtKB/Swiss-Prot
    Q9HD89
    Related
    ENSP00000221515.1, OTTHUMP00000269453, ENST00000221515.5, OTTHUMT00000461731
    Conserved Domains (1) summary
    pfam06954
    Location:20106
    Resistin; Resistin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    7669086..7670454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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