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TRIM54 tripartite motif containing 54 [ Homo sapiens (human) ]

Gene ID: 57159, updated on 8-Jul-2018
Official Symbol
TRIM54provided by HGNC
Official Full Name
tripartite motif containing 54provided by HGNC
Primary source
HGNC:HGNC:16008
See related
Ensembl:ENSG00000138100 MIM:606474; Vega:OTTHUMG00000097078
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MURF; RNF30; muRF3; MURF-3
Summary
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 35.4), testis (RPKM 5.2) and 2 other tissues See more
Orthologs
See TRIM54 in Genome Data Viewer
Location:
2p23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (27282429..27307439)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27505297..27530307)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene solute carrier family 30 member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene MPV17, mitochondrial inner membrane protein Neighboring gene urocortin Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene GTF3C2 antisense RNA 1

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
microtubule-based process NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of microtubule depolymerization NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Z disc IEA
Inferred from Electronic Annotation
more info
 
microtubule NAS
Non-traceable Author Statement
more info
PubMed 
microtubule associated complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tripartite motif-containing protein 54
Names
muscle-specific RING finger protein 3
ring finger protein 30

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032546.3NP_115935.3  tripartite motif-containing protein 54 isoform 1

    See identical proteins and their annotated locations for NP_115935.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ291714, BC141807, CA423735, DA897004
    Consensus CDS
    CCDS1745.2
    UniProtKB/Swiss-Prot
    Q9BYV2
    Related
    ENSP00000296098.4, OTTHUMP00000122597, ENST00000296098.4, OTTHUMT00000214198
    Conserved Domains (2) summary
    pfam00643
    Location:122163
    zf-B_box; B-box zinc finger
    cd16761
    Location:2482
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
  2. NM_187841.2NP_912730.2  tripartite motif-containing protein 54 isoform 2

    See identical proteins and their annotated locations for NP_912730.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment within the coding region. The resulting shorter isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    BC141807, CA423735, DA897004
    Consensus CDS
    CCDS1746.2
    UniProtKB/Swiss-Prot
    Q9BYV2
    Related
    ENSP00000369415.2, OTTHUMP00000122598, ENST00000380075.6, OTTHUMT00000214199
    Conserved Domains (2) summary
    pfam00643
    Location:122163
    zf-B_box; B-box zinc finger
    cd16761
    Location:2482
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    27282429..27307439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453011.1XP_024308779.1  tripartite motif-containing protein 54 isoform X2

    Conserved Domains (2) summary
    pfam00643
    Location:122163
    zf-B_box; B-box zinc finger
    cd16761
    Location:2482
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
  2. XM_024453010.1XP_024308778.1  tripartite motif-containing protein 54 isoform X1

    Conserved Domains (2) summary
    pfam00643
    Location:122163
    zf-B_box; B-box zinc finger
    cd16761
    Location:2482
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
  3. XM_024453012.1XP_024308780.1  tripartite motif-containing protein 54 isoform X3

    Conserved Domains (2) summary
    pfam00643
    Location:122163
    zf-B_box; B-box zinc finger
    cd16761
    Location:2482
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
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