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TRIM54 tripartite motif containing 54 [ Homo sapiens (human) ]

Gene ID: 57159, updated on 2-Nov-2024

Summary

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Official Symbol
TRIM54provided by HGNC
Official Full Name
tripartite motif containing 54provided by HGNC
Primary source
HGNC:HGNC:16008
See related
Ensembl:ENSG00000138100 MIM:606474; AllianceGenome:HGNC:16008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MURF; RNF30; muRF3; MURF-3
Summary
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Biased expression in heart (RPKM 35.4), testis (RPKM 5.2) and 2 other tissues See more
Orthologs
mouse all
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Genomic context

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See TRIM54 in Genome Data Viewer
Location:
2p23.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27282429..27307435)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27322074..27349850)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27505297..27530303)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11291 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27454350-27455549 Neighboring gene carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27465505-27466704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27472326-27473120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:27473121-27473914 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11293 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11294 Neighboring gene solute carrier family 30 member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11295 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11296 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma Neighboring gene ReSE screen-validated silencer GRCh37_chr2:27524348-27524553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27543343-27543946 Neighboring gene Sharpr-MPRA regulatory regions 9483 and 12628 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15498 Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:27545801-27546773 Neighboring gene urocortin Neighboring gene general transcription factor IIIC subunit 2 Neighboring gene GTF3C2 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma. Liu MR, et al. Hepatol Commun, 2023 Oct 1. PMID 37695069, Free PMC Article
  2. Tripartite motif-containing 54 promotes gastric cancer progression by upregulating K63-linked ubiquitination of filamin C. Cao H, et al. Asia Pac J Clin Oncol, 2022 Dec. PMID 35098666
  3. Targeting TRIM54/Axin1/β-Catenin Axis Prohibits Proliferation and Metastasis in Hepatocellular Carcinoma. Zhu J, et al. Front Oncol, 2021. PMID 34956880, Free PMC Article
  4. New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations. Olivé M, et al. Hum Mol Genet, 2015 Jul 1. PMID 25801283
  5. Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. Spencer JA, et al. J Cell Biol, 2000 Aug 21. PMID 10953002, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.
    Title: Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.
  2. A novel protein aggregate myopathies and cardiomyopathy resulting from combined homozygous MuRF1 null mutation and heterozygous MuRF3 missense mutation.
    Title: New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations.
  3. Functional analysis of the mouse counterpart.
    Title: Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule NAS
Non-traceable Author Statement
more info
 PubMed 
part_of microtubule associated complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tripartite motif-containing protein 54
Names
muscle-specific RING finger protein 3
ring finger protein 30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032546.4 → NP_115935.3  tripartite motif-containing protein 54 isoform 1

    See identical proteins and their annotated locations for NP_115935.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AJ291714, BC141807, DA897004
    Consensus CDS
    CCDS1745.2
    UniProtKB/Swiss-Prot
    Q9BYV2
    Related
    ENSP00000296098.4, ENST00000296098.4
    Conserved Domains (2) summary
    cd16761
    Location:24 → 82
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins
    cd19833
    Location:124 → 166
    Bbox2_MuRF3_C-II; B-box-type 2 zinc finger found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

  2. NM_187841.3 → NP_912730.2  tripartite motif-containing protein 54 isoform 2

    See identical proteins and their annotated locations for NP_912730.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment within the coding region. The resulting shorter isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    BC141807, DA897004
    Consensus CDS
    CCDS1746.2
    UniProtKB/Swiss-Prot
    A5D8T7, Q53SY4, Q9BYV2, Q9BYV3
    Related
    ENSP00000369415.3, ENST00000380075.7
    Conserved Domains (2) summary
    pfam00643
    Location:122 → 163
    zf-B_box; B-box zinc finger
    cd16761
    Location:24 → 82
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    27282429..27307435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453010.1 → XP_024308778.1  tripartite motif-containing protein 54 isoform X1

    UniProtKB/Swiss-Prot
    A5D8T7, Q53SY4, Q9BYV2, Q9BYV3
    Conserved Domains (2) summary
    pfam00643
    Location:122 → 163
    zf-B_box; B-box zinc finger
    cd16761
    Location:24 → 82
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

  2. XM_024453011.2 → XP_024308779.1  tripartite motif-containing protein 54 isoform X2

    Conserved Domains (2) summary
    pfam00643
    Location:122 → 163
    zf-B_box; B-box zinc finger
    cd16761
    Location:24 → 82
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

  3. XM_024453012.2 → XP_024308780.1  tripartite motif-containing protein 54 isoform X3

    Conserved Domains (2) summary
    pfam00643
    Location:122 → 163
    zf-B_box; B-box zinc finger
    cd16761
    Location:24 → 82
    RING-HC_MuRF3; RING finger, HC subclass, found in muscle-specific RING finger protein 3 (MuRF-3) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    27322074..27349850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343071.1 → XP_054199046.1  tripartite motif-containing protein 54 isoform X1

    UniProtKB/Swiss-Prot
    A5D8T7, Q53SY4, Q9BYV2, Q9BYV3

  2. XM_054343070.1 → XP_054199045.1  tripartite motif-containing protein 54 isoform X1

    UniProtKB/Swiss-Prot
    A5D8T7, Q53SY4, Q9BYV2, Q9BYV3

  3. XM_054343072.1 → XP_054199047.1  tripartite motif-containing protein 54 isoform X2

  4. XM_054343073.1 → XP_054199048.1  tripartite motif-containing protein 54 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BYV2.3 GenPept UniProtKB/Swiss-Prot:Q9BYV2

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