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RNPEPL1 arginyl aminopeptidase like 1 [ Homo sapiens (human) ]

Gene ID: 57140, updated on 21-Dec-2019

Summary

Official Symbol
RNPEPL1provided by HGNC
Official Full Name
arginyl aminopeptidase like 1provided by HGNC
Primary source
HGNC:HGNC:10079
See related
Ensembl:ENSG00000142327 MIM:605287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in spleen (RPKM 21.6), fat (RPKM 21.2) and 25 other tissues See more
Orthologs

Genomic context

See RNPEPL1 in Genome Data Viewer
Location:
2q37.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (240568484..240581372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241507952..241518149)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100130449 Neighboring gene glypican 1 Neighboring gene microRNA 149 Neighboring gene ankyrin repeat and MYND domain containing 1 Neighboring gene conserved acetylation island sequence C08 enhancer Neighboring gene dual specificity phosphatase 28 Neighboring gene Sharpr-MPRA regulatory region 5965 Neighboring gene CAPN10 divergent transcript Neighboring gene calpain 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10806, FLJ26675, MGC99544

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metalloaminopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aminopeptidase RNPEPL1
Names
RNPEP-like 1
aminopeptidase B-like 1
argininyl aminopeptidase-like 1
arginyl aminopeptidase (aminopeptidase B)-like 1
methionyl aminopeptidase
NP_060696.4
XP_005247093.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018226.6NP_060696.4  aminopeptidase RNPEPL1

    See identical proteins and their annotated locations for NP_060696.4

    Status: VALIDATED

    Source sequence(s)
    AC124862, BC017301, BC082975
    UniProtKB/Swiss-Prot
    Q9HAU8
    Related
    ENSP00000270357.4, ENST00000270357.10
    Conserved Domains (2) summary
    cd09599
    Location:29512
    M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
    pfam09127
    Location:529673
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    240568484..240581372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247036.4XP_005247093.1  aminopeptidase RNPEPL1 isoform X1

    Conserved Domains (2) summary
    pfam09127
    Location:518662
    Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    cl14813
    Location:29495
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
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