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Psychiatr Genet. 2010 Jun;20(3):126-9. doi: 10.1097/YPG.0b013e32833a2050.

Family-based association study for bipolar affective disorder.

Author information

1
Department of Medical Genetics, University of Campinas-UNICAMP, Campinas, Sao Paulo, Brazil.

Abstract

In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences.

PMID:
20414141
DOI:
10.1097/YPG.0b013e32833a2050
[Indexed for MEDLINE]

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