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CIAPIN1 cytokine induced apoptosis inhibitor 1 [ Homo sapiens (human) ]

Gene ID: 57019, updated on 7-Oct-2018

Summary

Official Symbol
CIAPIN1provided by HGNC
Official Full Name
cytokine induced apoptosis inhibitor 1provided by HGNC
Primary source
HGNC:HGNC:28050
See related
Ensembl:ENSG00000005194 MIM:608943; Vega:OTTHUMG00000133457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRE2; CIAE2; PRO0915; Anamorsin
Summary
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues See more
Orthologs

Genomic context

See CIAPIN1 in Genome Data Viewer
Location:
16q21
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (57428169..57447528, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (57462081..57481439, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene C-X3-C motif chemokine ligand 1 Neighboring gene C-C motif chemokine ligand 17 Neighboring gene coenzyme Q9 Neighboring gene RNA polymerase II subunit C Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene adhesion G protein-coupled receptor G5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cytosolic iron-sulfur cluster assembly, organism-specific biosystem (from REACTOME)
    Cytosolic iron-sulfur cluster assembly, organism-specific biosystemIron-sulfur clusters containing 4 atoms of iron and 4 atoms of sulfur (4Fe-4S clusters) are assembled in the cytosol on a heterotetrameric scaffold composed of NUBP2 and NUBP1 subunits (reviewed in L...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
methylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
anamorsin
Names
fe-S cluster assembly protein DRE2 homolog
predicted protein of HQ0915

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308347.1NP_001295276.1  anamorsin isoform 2

    See identical proteins and their annotated locations for NP_001295276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 2.
    Source sequence(s)
    AC009052, AL136613, BC067303, CA443135
    Consensus CDS
    CCDS76876.1
    UniProtKB/Swiss-Prot
    Q6FI81
    Related
    ENSP00000456114.1, OTTHUMP00000254115, ENST00000567518.5, OTTHUMT00000431013
    Conserved Domains (1) summary
    pfam05093
    Location:227291
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
  2. NM_001308358.1NP_001295287.1  anamorsin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The encoded isoform (3)
    Source sequence(s)
    AC009052, AF248964, BC067303, BG746807, BJ991015, CA443135
    Consensus CDS
    CCDS76877.1
    UniProtKB/Swiss-Prot
    Q6FI81
    UniProtKB/TrEMBL
    H3BT65
    Related
    ENSP00000457042.1, OTTHUMP00000254117, ENST00000569370.5, OTTHUMT00000431015
    Conserved Domains (1) summary
    cl17173
    Location:395
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_020313.3NP_064709.2  anamorsin isoform 1

    See identical proteins and their annotated locations for NP_064709.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC009052, AF248964, BC024196, BC067303, CA443135
    Consensus CDS
    CCDS10781.2
    UniProtKB/Swiss-Prot
    Q6FI81
    Related
    ENSP00000377914.4, OTTHUMP00000164661, ENST00000394391.8, OTTHUMT00000257332
    Conserved Domains (2) summary
    pfam05093
    Location:240304
    CIAPIN1; Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
    cl17173
    Location:395
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    57428169..57447528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256063.5XP_005256120.1  anamorsin isoform X1

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