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ACKR3 atypical chemokine receptor 3 [ Homo sapiens (human) ]

Gene ID: 57007, updated on 1-Jun-2020

Summary

Official Symbol
ACKR3provided by HGNC
Official Full Name
atypical chemokine receptor 3provided by HGNC
Primary source
HGNC:HGNC:23692
See related
Ensembl:ENSG00000144476 MIM:610376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
Summary
This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 50.1), urinary bladder (RPKM 36.9) and 22 other tissues See more
Orthologs

Genomic context

See ACKR3 in Genome Data Viewer
Location:
2q37.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (236537131..236582358)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (237469424..237491001)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373945 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene ribosomal protein L3 pseudogene 5 Neighboring gene uncharacterized LOC105373991 Neighboring gene uncharacterized LOC107986001 Neighboring gene uncharacterized LOC105373946

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
C-X-C chemokine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
C-X-C chemokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coreceptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scavenger receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mesenchymal stem cell migration IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IEA
Inferred from Electronic Annotation
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
atypical chemokine receptor 3
Names
C-X-C chemokine receptor type 7
G protein-coupled receptor
G-protein coupled receptor 159
G-protein coupled receptor RDC1 homolog
chemokine (C-X-C motif) receptor 7
chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020311.3NP_064707.1  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_064707.1

    Status: REVIEWED

    Source sequence(s)
    BC036661, BP426139, DQ822477
    Consensus CDS
    CCDS2516.1
    UniProtKB/Swiss-Prot
    P25106
    Related
    ENSP00000272928.3, ENST00000272928.4
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    236537131..236582358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246098.3XP_005246155.1  atypical chemokine receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_005246155.1

    UniProtKB/Swiss-Prot
    P25106
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_017004516.2XP_016860005.1  atypical chemokine receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    P25106
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_005246097.3XP_005246154.1  atypical chemokine receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_005246154.1

    UniProtKB/Swiss-Prot
    P25106
    Conserved Domains (1) summary
    pfam00001
    Location:62315
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047841.1: Suppressed sequence

    Description
    NM_001047841.1: This RefSeq was permanently suppressed because it has a none consensus splice site that does not have enough supporting evidence.
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