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DUSP22 dual specificity phosphatase 22 [ Homo sapiens (human) ]

Gene ID: 56940, updated on 8-Dec-2018

Summary

Official Symbol
DUSP22provided by HGNC
Official Full Name
dual specificity phosphatase 22provided by HGNC
Primary source
HGNC:HGNC:16077
See related
Ensembl:ENSG00000112679 MIM:616778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
Expression
Ubiquitous expression in testis (RPKM 10.7), spleen (RPKM 5.4) and 25 other tissues See more
Orthologs

Genomic context

See DUSP22 in Genome Data Viewer
Location:
6p25.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (292057..351355)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (292101..351355)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374870 Neighboring gene uncharacterized LOC102723922 Neighboring gene uncharacterized LOC107986553 Neighboring gene interferon regulatory factor 4 Neighboring gene uncharacterized LOC105374875

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35864

Gene Ontology Provided by GOA

Function Evidence Code Pubs
non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
inactivation of MAPK activity TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of non-membrane spanning protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
leading edge of lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 22
Names
JNK-stimulating phosphatase 1
JNK-stimulatory phosphatase-1
MAP kinase phosphatase x
epididymis secretory sperm binding protein
homolog of mouse dual specificity phosphatase LMW-DSP2
low molecular weight dual specificity phosphatase 2
mitogen-activated protein kinase phosphatase x
NP_001273484.1
NP_064570.1
XP_011513059.1
XP_016866550.1
XP_016866551.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286555.1NP_001273484.1  dual specificity protein phosphatase 22 isoform a

    See identical proteins and their annotated locations for NP_001273484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK296402, AL365272, AY249859, BX107497
    Consensus CDS
    CCDS69035.1
    UniProtKB/Swiss-Prot
    Q9NRW4
    Related
    ENSP00000397459.2, ENST00000419235.6
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_020185.4NP_064570.1  dual specificity protein phosphatase 22 isoform b

    See identical proteins and their annotated locations for NP_064570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 3' coding region and 3' UTR and includes an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AF424702, AY249859, BX107497
    Consensus CDS
    CCDS4468.1
    UniProtKB/Swiss-Prot
    Q9NRW4
    Related
    ENSP00000345281.5, ENST00000344450.9
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. NR_104473.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, DA950312
  2. NR_104474.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, DB177174
  3. NR_104475.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272, AY249859, BX107497, BX362191

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    292057..351355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011061.1XP_016866550.1  dual specificity protein phosphatase 22 isoform X1

  2. XM_011514757.2XP_011513059.1  dual specificity protein phosphatase 22 isoform X2

    Conserved Domains (1) summary
    cd00127
    Location:579
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  3. XM_017011062.1XP_016866551.1  dual specificity protein phosphatase 22 isoform X3

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