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DUSP22 dual specificity phosphatase 22 [ Homo sapiens (human) ]

Gene ID: 56940, updated on 12-Aug-2022

Summary

Official Symbol
DUSP22provided by HGNC
Official Full Name
dual specificity phosphatase 22provided by HGNC
Primary source
HGNC:HGNC:16077
See related
Ensembl:ENSG00000112679 MIM:616778; AllianceGenome:HGNC:16077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
Summary
Enables non-membrane spanning protein tyrosine phosphatase activity and protein tyrosine kinase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of focal adhesion assembly; and negative regulation of non-membrane spanning protein tyrosine kinase activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in plasma membrane. Part of cytoplasm; filamentous actin; and leading edge of lamellipodium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.7), spleen (RPKM 5.4) and 25 other tissues See more
Orthologs
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Genomic context

See DUSP22 in Genome Data Viewer
Location:
6p25.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (292487..351355)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (147423..206310)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (292487..351355)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374869 Neighboring gene uncharacterized LOC285766 Neighboring gene uncharacterized LOC105374870 Neighboring gene interferon regulatory factor 4 Neighboring gene exocyst complex component 2 Neighboring gene HUS1 checkpoint clamp component B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35864

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell mediated immunity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of focal adhesion assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of non-membrane spanning protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
located_in leading edge of lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 22
Names
JNK-stimulating phosphatase 1
JNK-stimulatory phosphatase-1
MAP kinase phosphatase x
epididymis secretory sperm binding protein
homolog of mouse dual specificity phosphatase LMW-DSP2
low molecular weight dual specificity phosphatase 2
mitogen-activated protein kinase phosphatase x
NP_001273484.1
NP_064570.1
XP_011513059.1
XP_016866551.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286555.3NP_001273484.1  dual specificity protein phosphatase 22 isoform a

    See identical proteins and their annotated locations for NP_001273484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL365272
    Consensus CDS
    CCDS69035.1
    UniProtKB/Swiss-Prot
    Q9NRW4
    Related
    ENSP00000397459.2, ENST00000419235.7
    Conserved Domains (1) summary
    cd14581
    Location:2150
    DUSP22; dual specificity protein phosphatase 22
  2. NM_020185.6NP_064570.1  dual specificity protein phosphatase 22 isoform b

    See identical proteins and their annotated locations for NP_064570.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a segment of the 3' coding region and 3' UTR and includes an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AL365272
    Consensus CDS
    CCDS4468.1
    UniProtKB/Swiss-Prot
    Q96AR1, Q9NRW4
    UniProtKB/TrEMBL
    A0A384NLC8
    Related
    ENSP00000345281.5, ENST00000344450.9
    Conserved Domains (1) summary
    cd14581
    Location:2150
    DUSP22; dual specificity protein phosphatase 22

RNA

  1. NR_104473.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272
  2. NR_104474.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272
  3. NR_104475.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL365272

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    292487..351355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514757.3XP_011513059.1  dual specificity protein phosphatase 22 isoform X1

    Conserved Domains (1) summary
    cd00127
    Location:579
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. XM_017011062.2XP_016866551.1  dual specificity protein phosphatase 22 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    147423..206310
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)