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Dusp22 dual specificity phosphatase 22 [ Mus musculus (house mouse) ]

Gene ID: 105352, updated on 8-Feb-2024

Summary

Official Symbol
Dusp22provided by MGI
Official Full Name
dual specificity phosphatase 22provided by MGI
Primary source
MGI:MGI:1915926
See related
Ensembl:ENSMUSG00000069255 AllianceGenome:MGI:1915926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JKAP; JSP1; MKPX; LMW-DSP2
Summary
Enables protein tyrosine kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within several processes, including negative regulation of T cell mediated immunity; regulation of signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm; leading edge of lamellipodium; and plasma membrane. Predicted to be part of filamentous actin. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and somite. Orthologous to human DUSP22 (dual specificity phosphatase 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 7.7), mammary gland adult (RPKM 7.2) and 28 other tissues See more
Orthologs
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Genomic context

See Dusp22 in Genome Data Viewer
Location:
13 A3.2; 13 13.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30844042..30895215)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30660059..30711232)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930519D14 gene Neighboring gene STARR-positive B cell enhancer ABC_E5386 Neighboring gene predicted gene, 35158 Neighboring gene STARR-seq mESC enhancer starr_34069 Neighboring gene STARR-positive B cell enhancer ABC_E10787 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:30853140-30853323 Neighboring gene interferon regulatory factor 4 Neighboring gene exocyst complex component 2 Neighboring gene HUS1 checkpoint clamp component B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC118031, RP23-217J3.1, 1110028K04Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
located_in leading edge of lamellipodium ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 22
Names
low molecular weight dual specificity phosphatase 2
NP_001033044.1
NP_598829.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037955.4NP_001033044.1  dual specificity protein phosphatase 22 isoform a

    See identical proteins and their annotated locations for NP_001033044.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA137950, AK003947, AK148708, AK149363, BY477408, CX236611
    Consensus CDS
    CCDS26418.1
    UniProtKB/Swiss-Prot
    Q99N11
    Related
    ENSMUSP00000093603.6, ENSMUST00000095914.7
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
  2. NM_134068.4NP_598829.1  dual specificity protein phosphatase 22 isoform b

    See identical proteins and their annotated locations for NP_598829.1

    Status: VALIDATED

    Source sequence(s)
    AA137950, AK003947, AK148708, BY477408, CX236611
    Consensus CDS
    CCDS26417.1
    UniProtKB/Swiss-Prot
    Q5SQN9, Q5SQP0, Q99N11
    Related
    ENSMUSP00000089260.7, ENSMUST00000091672.13
    Conserved Domains (1) summary
    cd00127
    Location:4139
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30844042..30895215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)