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LXN latexin [ Homo sapiens (human) ]

Gene ID: 56925, updated on 27-Nov-2024

Summary

Official Symbol
LXNprovided by HGNC
Official Full Name
latexinprovided by HGNC
Primary source
HGNC:HGNC:13347
See related
Ensembl:ENSG00000079257 MIM:609305; AllianceGenome:HGNC:13347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECI; TCI
Summary
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. The encoded protein, latexin, downregulates the population size of hematopoietic stem cells. This protein is found to be downregulated in cancer cells because of promoter hypermethylation. [provided by RefSeq, Jul 2020]
Expression
Ubiquitous expression in ovary (RPKM 17.1), gall bladder (RPKM 15.4) and 24 other tissues See more
Orthologs
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Genomic context

See LXN in Genome Data Viewer
Location:
3q25.32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (158666414..158672648, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (161440336..161446570, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158384203..158390437, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene methylthioadenosine phosphorylase pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344231-158344732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158344733-158345232 Neighboring gene RFK pseudogene 6 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158389654-158390246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:158390247-158390839 Neighboring gene retinoic acid receptor responder 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:158430992-158432191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158433310-158433810 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158447157-158447335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14848 Neighboring gene uncharacterized LOC100287290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:158450198-158450698 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:158478422-158478617 Neighboring gene ribosomal protein L35a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
latexin
Names
MUM
endogenous carboxypeptidase inhibitor
tissue carboxypeptidase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020169.4NP_064554.3  latexin

    See identical proteins and their annotated locations for NP_064554.3

    Status: REVIEWED

    Source sequence(s)
    AF087851, BC005346, BC008438
    Consensus CDS
    CCDS3183.1
    UniProtKB/Swiss-Prot
    Q96PN2, Q9BS40, Q9NQS6
    Related
    ENSP00000264265.3, ENST00000264265.4
    Conserved Domains (1) summary
    pfam06907
    Location:3218
    Latexin; Latexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    158666414..158672648 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    161440336..161446570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)