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LXN latexin [ Homo sapiens (human) ]

Gene ID: 56925, updated on 12-Oct-2019

Summary

Official Symbol
LXNprovided by HGNC
Official Full Name
latexinprovided by HGNC
Primary source
HGNC:HGNC:13347
See related
Ensembl:ENSG00000079257 MIM:609305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECI; TCI
Summary
This gene encodes the only known protein inhibitor of zinc-dependent metallocarboxypeptidases. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in ovary (RPKM 17.1), gall bladder (RPKM 15.4) and 24 other tissues See more
Orthologs

Genomic context

See LXN in Genome Data Viewer
Location:
3q25.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (158666414..158672722, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (158384203..158390482, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myeloid leukemia factor 1 Neighboring gene methylthioadenosine phosphorylase pseudogene 1 Neighboring gene G elongation factor mitochondrial 1 Neighboring gene uncharacterized LOC112268457 Neighboring gene retinoic acid receptor responder 1 Neighboring gene cytokine receptor CRL2 Neighboring gene ribosomal protein L35a pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
detection of temperature stimulus involved in sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
latexin
Names
MUM
endogenous carboxypeptidase inhibitor
tissue carboxypeptidase inhibitor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020169.4NP_064554.3  latexin

    See identical proteins and their annotated locations for NP_064554.3

    Status: REVIEWED

    Source sequence(s)
    AF087851, BC005346, BC008438
    Consensus CDS
    CCDS3183.1
    UniProtKB/Swiss-Prot
    Q9BS40
    Related
    ENSP00000264265.3, ENST00000264265.4
    Conserved Domains (1) summary
    pfam06907
    Location:3218
    Latexin; Latexin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    158666414..158672722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006876.1XP_016862365.1  latexin isoform X1

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