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Lxn latexin [ Mus musculus (house mouse) ]

Gene ID: 17035, updated on 13-Oct-2022

Summary

Official Symbol
Lxnprovided by MGI
Official Full Name
latexinprovided by MGI
Primary source
MGI:MGI:107633
See related
Ensembl:ENSMUSG00000047557 AllianceGenome:MGI:107633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables metalloendopeptidase inhibitor activity. Acts upstream of or within detection of temperature stimulus involved in sensory perception of pain. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in cartilage; nervous system; and tibia. Orthologous to human LXN (latexin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 37.5), lung adult (RPKM 36.3) and 27 other tissues See more
Orthologs
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Genomic context

See Lxn in Genome Data Viewer
Location:
3 E1; 3 30.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (67365332..67371240, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (67457999..67463907, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene arginine/serine-rich coiled-coil 1 Neighboring gene predicted gene, 22295 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene retinoic acid receptor responder (tazarotene induced) 1 Neighboring gene predicted gene, 40067 Neighboring gene predicted gene, 35299

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC144352, MGC144353

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
latexin
Names
ECI
TCI
endogenous carboxypeptidase inhibitor
tissue carboxypeptidase inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016753.4NP_058033.2  latexin

    See identical proteins and their annotated locations for NP_058033.2

    Status: PROVISIONAL

    Source sequence(s)
    AC124190
    Consensus CDS
    CCDS17397.1
    UniProtKB/Swiss-Prot
    P70202, Q8CCS8
    UniProtKB/TrEMBL
    Q14BZ3
    Related
    ENSMUSP00000060732.3, ENSMUST00000058981.3
    Conserved Domains (1) summary
    pfam06907
    Location:3219
    Latexin; Latexin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    67365332..67371240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)