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AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 56895, updated on 7-Jun-2020

Summary

Official Symbol
AGPAT4provided by HGNC
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:20885
See related
Ensembl:ENSG00000026652 MIM:614795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
1-AGPAT4; dJ473J16.2; LPAAT-delta
Summary
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 9.7), placenta (RPKM 3.7) and 18 other tissues See more
Orthologs

Genomic context

See AGPAT4 in Genome Data Viewer
Location:
6q26
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (161129967..161274108, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161551057..161695107, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724087 Neighboring gene Sharpr-MPRA regulatory region 6130 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene Sharpr-MPRA regulatory region 12533 Neighboring gene AGPAT4 intronic transcript 1 Neighboring gene uncharacterized LOC105378094 Neighboring gene uncharacterized LOC105378098 Neighboring gene parkin RBR E3 ubiquitin protein ligase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-acylglycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-acylglycerol-3-phosphate O-acyltransferase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transferase activity, transferring acyl groups IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Names
1-AGP acyltransferase 4
1-AGPAT 4
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)
lysophosphatidic acid acyltransferase delta
lysophosphatidic acid acyltransferase-delta (LPAAT-delta)
NP_064518.1
XP_005267110.1
XP_006715577.1
XP_016866548.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020133.3NP_064518.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

    See identical proteins and their annotated locations for NP_064518.1

    Status: REVIEWED

    Source sequence(s)
    AF156776, AL109942, AL122123, BQ072907
    Consensus CDS
    CCDS5280.1
    UniProtKB/Swiss-Prot
    Q9NRZ5
    Related
    ENSP00000314036.4, ENST00000320285.9
    Conserved Domains (3) summary
    cd07990
    Location:62256
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    PLN02380
    Location:20345
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
    pfam16076
    Location:243314
    Acyltransf_C; Acyltransferase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    161129967..161274108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011059.1XP_016866548.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    Conserved Domains (2) summary
    cd07990
    Location:1122
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:109180
    Acyltransf_C; Acyltransferase C-terminus
  2. XM_005267053.3XP_005267110.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_005267110.1

    Conserved Domains (2) summary
    cd07990
    Location:1122
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:109180
    Acyltransf_C; Acyltransferase C-terminus
  3. XM_006715514.3XP_006715577.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

    See identical proteins and their annotated locations for XP_006715577.1

    Conserved Domains (2) summary
    cd07990
    Location:62202
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:189260
    Acyltransf_C; Acyltransferase C-terminus

RNA

  1. XR_001743516.1 RNA Sequence

    Related
    ENST00000366911.9

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012733.1: Suppressed sequence

    Description
    NM_001012733.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_001012734.1: Suppressed sequence

    Description
    NM_001012734.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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