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Agpat4 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) [ Mus musculus (house mouse) ]

Gene ID: 68262, updated on 5-Jan-2023

Summary

Official Symbol
Agpat4provided by MGI
Official Full Name
1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)provided by MGI
Primary source
MGI:MGI:1915512
See related
Ensembl:ENSMUSG00000023827 AllianceGenome:MGI:1915512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500003P24Rik
Summary
Enables 1-acylglycerol-3-phosphate O-acyltransferase activity. Involved in phospholipid metabolic process. Located in endoplasmic reticulum. Is active in mitochondrial outer membrane. Is expressed in several structures, including nervous system; skin; stomach; and testis. Orthologous to human AGPAT4 (1-acylglycerol-3-phosphate O-acyltransferase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 23.0), lung adult (RPKM 13.9) and 27 other tissues See more
Orthologs
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Genomic context

See Agpat4 in Genome Data Viewer
Location:
17; 17 A1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12337372..12438536)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12118485..12219649)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene parkin RBR E3 ubiquitin protein ligase Neighboring gene DNA segment, Chr 17, ERATO Doi 648, expressed Neighboring gene predicted gene, 46604 Neighboring gene VISTA enhancer mm156 Neighboring gene teratocarcinoma-derived growth factor, pseudogene 2 Neighboring gene mitogen-activated protein kinase kinase kinase 4 Neighboring gene predicted gene, 46605 Neighboring gene predicted gene, 24794

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 1-acylglycerol-3-phosphate O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Names
1-AGP acyltransferase 4
1-AGPAT 4
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, delta)
LPAAT-delta
lysophosphatidic acid acyltransferase-delta
NP_080920.2
XP_006523408.3
XP_006523410.1
XP_006523411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026644.2NP_080920.2  1-acyl-sn-glycerol-3-phosphate acyltransferase delta

    See identical proteins and their annotated locations for NP_080920.2

    Status: PROVISIONAL

    Source sequence(s)
    AK005139
    Consensus CDS
    CCDS28389.1
    UniProtKB/Swiss-Prot
    Q8K4X7, Q9DB84
    UniProtKB/TrEMBL
    A0A6P5NV87, A0A8C6H783
    Related
    ENSMUSP00000024594.3, ENSMUST00000024594.9
    Conserved Domains (1) summary
    PLN02380
    Location:20326
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    12337372..12438536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523347.3XP_006523410.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_006523410.1

    Conserved Domains (2) summary
    cd07990
    Location:11150
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:136208
    Acyltransf_C; Acyltransferase C-terminus
  2. XM_006523345.3XP_006523408.3  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X1

    Conserved Domains (1) summary
    PLN02380
    Location:100406
    PLN02380; 1-acyl-sn-glycerol-3-phosphate acyltransferase
  3. XM_006523348.5XP_006523411.1  1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2

    See identical proteins and their annotated locations for XP_006523411.1

    Conserved Domains (2) summary
    cd07990
    Location:11150
    LPLAT_LCLAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like
    pfam16076
    Location:136208
    Acyltransf_C; Acyltransferase C-terminus