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PSMA5 proteasome 20S subunit alpha 5 [ Homo sapiens (human) ]

Gene ID: 5686, updated on 5-Sep-2021

Summary

Official Symbol
PSMA5provided by HGNC
Official Full Name
proteasome 20S subunit alpha 5provided by HGNC
Primary source
HGNC:HGNC:9534
See related
Ensembl:ENSG00000143106 MIM:176844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSC5; ZETA
Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Expression
Ubiquitous expression in lymph node (RPKM 14.6), appendix (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

See PSMA5 in Genome Data Viewer
Location:
1p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (109399042..109426448, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (109941664..109969070, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene myosin binding protein H like Neighboring gene sortilin 1 Neighboring gene synaptophysin like 2 Neighboring gene ataxin 7 like 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of proteasome (prosome, macropain) subunit, alpha type, 5 (PSMA5) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42315, MGC117302, MGC125802, MGC125803, MGC125804

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proteasome subunit alpha type-5
Names
epididymis tissue sperm binding protein Li 11n
macropain subunit zeta
macropain zeta chain
multicatalytic endopeptidase complex zeta chain
proteasome (prosome, macropain) subunit, alpha type, 5
proteasome alpha 5 subunit
proteasome component 5
proteasome subunit alpha 5
proteasome subunit zeta
proteasome zeta chain
NP_001186701.1
NP_001186702.1
NP_001186703.1
NP_002781.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199772.2NP_001186701.1  proteasome subunit alpha type-5 isoform 2

    See identical proteins and their annotated locations for NP_001186701.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK304448, AL390252, DC324498, H08369
    Consensus CDS
    CCDS55619.1
    UniProtKB/Swiss-Prot
    P28066
    Conserved Domains (1) summary
    cl00467
    Location:1162
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  2. NM_001199773.2NP_001186702.1  proteasome subunit alpha type-5 isoform 2

    See identical proteins and their annotated locations for NP_001186702.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL390252, BI825400, H08369
    Consensus CDS
    CCDS55619.1
    UniProtKB/Swiss-Prot
    P28066
    Conserved Domains (1) summary
    cl00467
    Location:1162
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  3. NM_001199774.2NP_001186703.1  proteasome subunit alpha type-5 isoform 2

    See identical proteins and their annotated locations for NP_001186703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR exon, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL390252, BM793388, DC324021, H08369
    Consensus CDS
    CCDS55619.1
    UniProtKB/Swiss-Prot
    P28066
    Related
    ENSP00000440618.1, ENST00000538610.5
    Conserved Domains (1) summary
    cl00467
    Location:1162
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
  4. NM_002790.4NP_002781.2  proteasome subunit alpha type-5 isoform 1

    See identical proteins and their annotated locations for NP_002781.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK225990, AK313351, AL390252, H08369
    Consensus CDS
    CCDS799.1
    UniProtKB/Swiss-Prot
    P28066
    UniProtKB/TrEMBL
    A0A109NGN6
    Related
    ENSP00000271308.4, ENST00000271308.9
    Conserved Domains (1) summary
    cd03753
    Location:8220
    proteasome_alpha_type_5; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    109399042..109426448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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