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GRIPAP1 GRIP1 associated protein 1 [ Homo sapiens (human) ]

Gene ID: 56850, updated on 1-Jun-2020

Summary

Official Symbol
GRIPAP1provided by HGNC
Official Full Name
GRIP1 associated protein 1provided by HGNC
Primary source
HGNC:HGNC:18706
See related
Ensembl:ENSG00000068400 MIM:300408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRASP-1
Summary
This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in brain (RPKM 17.5), spleen (RPKM 12.2) and 25 other tissues See more
Orthologs

Genomic context

See GRIPAP1 in Genome Data Viewer
Location:
Xp11.23
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (48973723..49002264, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48830130..48858675, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene OTU deubiquitinase 5 Neighboring gene RNA, U6 small nuclear 722, pseudogene Neighboring gene potassium voltage-gated channel subfamily D member 1 Neighboring gene Sharpr-MPRA regulatory region 9113 Neighboring gene Sharpr-MPRA regulatory region 2669 Neighboring gene transcription factor binding to IGHM enhancer 3 Neighboring gene coiled-coil domain containing 120

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1167, MGC126593, MGC126595, DKFZp434P0630

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of modification of synaptic structure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of recycling endosome localization within postsynapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
blood microparticle HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of postsynaptic early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016263.2 RefSeqGene

    Range
    5003..33547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_020137.5NP_064522.4  GRIP1-associated protein 1

    Status: REVIEWED

    Source sequence(s)
    AC233294
    Consensus CDS
    CCDS35248.1
    Related
    ENSP00000365606.5, ENST00000376423.8
    Conserved Domains (1) summary
    cl25732
    Location:7648
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    48973723..49002264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207672.1: Suppressed sequence

    Description
    NM_207672.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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