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PSG6 pregnancy specific beta-1-glycoprotein 6 [ Homo sapiens (human) ]

Gene ID: 5675, updated on 11-Jun-2021

Summary

Official Symbol
PSG6provided by HGNC
Official Full Name
pregnancy specific beta-1-glycoprotein 6provided by HGNC
Primary source
HGNC:HGNC:9523
See related
Ensembl:ENSG00000170848 MIM:176395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSG10; PSGGB; PSBG-6; PSBG-10; PSBG-12
Summary
This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. The protein encoded by this gene contains the Arg-Gly-Asp tripeptide associated with cellular adhesion and recognition. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Restricted expression toward placenta (RPKM 62.8) See more
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Genomic context

See PSG6 in Genome Data Viewer
Location:
19q13.31
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42902086..42917894, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43406238..43422046, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 10, pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 1 Neighboring gene pregnancy specific beta-1-glycoprotein 7 Neighboring gene CEA cell adhesion molecule pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PSG2

Potential readthrough

Included gene: PSG11

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in female pregnancy NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
pregnancy-specific beta-1-glycoprotein 6
Names
PS-beta-G-10
PS-beta-G-12
PS-beta-G-6
pregnancy-specific beta-1-glycoprotein 10
pregnancy-specific beta-1-glycoprotein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031850.4NP_001027020.1  pregnancy-specific beta-1-glycoprotein 6 isoform b precursor

    See identical proteins and their annotated locations for NP_001027020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI148792, BC020652, DA833634
    Consensus CDS
    CCDS33038.1
    UniProtKB/Swiss-Prot
    Q00889
    Related
    ENSP00000187910.3, ENST00000187910.7
    Conserved Domains (3) summary
    pfam13895
    Location:334412
    Ig_2; Immunoglobulin domain
    cd05774
    Location:36139
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cl11960
    Location:241328
    Ig; Immunoglobulin domain
  2. NM_002782.5NP_002773.1  pregnancy-specific beta-1-glycoprotein 6 isoform a precursor

    See identical proteins and their annotated locations for NP_002773.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    DA833634, M33666
    Consensus CDS
    CCDS12613.1
    UniProtKB/Swiss-Prot
    Q00889
    Related
    ENSP00000292125.2, ENST00000292125.6
    Conserved Domains (4) summary
    cd05774
    Location:36139
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:338398
    IG_like; Immunoglobulin like
    pfam13895
    Location:334412
    Ig_2; Immunoglobulin domain
    cl11960
    Location:241328
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    42902086..42917894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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