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Pf4 platelet factor 4 [ Mus musculus (house mouse) ]

Gene ID: 56744, updated on 16-Apr-2024

Summary

Official Symbol
Pf4provided by MGI
Official Full Name
platelet factor 4provided by MGI
Primary source
MGI:MGI:1888711
See related
Ensembl:ENSMUSG00000029373 AllianceGenome:MGI:1888711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cxcl4; Scyb4
Summary
Predicted to enable CXCR3 chemokine receptor binding activity; chemokine activity; and heparin binding activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to protozoan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including blood vessel; bone marrow; central nervous system; liver; and yolk sac. Orthologous to several human genes including PF4 (platelet factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 119.8), liver E14.5 (RPKM 114.1) and 13 other tissues See more
Orthologs
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Genomic context

See Pf4 in Genome Data Viewer
Location:
5 E1; 5 44.78 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90920362..90921242)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90772435..90773383)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene pro-platelet basic protein Neighboring gene STARR-seq mESC enhancer starr_13604 Neighboring gene C-X-C motif chemokine ligand 3 Neighboring gene C-X-C motif chemokine ligand 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables CXCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of T-helper 17 cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet factor 4
Names
C-X-C motif chemokine 4
chemokine (C-X-C motif) ligand 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019932.5NP_064316.1  platelet factor 4 precursor

    See identical proteins and their annotated locations for NP_064316.1

    Status: VALIDATED

    Source sequence(s)
    AC105995
    Consensus CDS
    CCDS19416.1
    UniProtKB/Swiss-Prot
    Q9Z126
    UniProtKB/TrEMBL
    Q3TVN6, Q6P8R3
    Related
    ENSMUSP00000031320.7, ENSMUST00000031320.8
    Conserved Domains (1) summary
    cd00273
    Location:41104
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90920362..90921242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)