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Pf4 platelet factor 4 [ Mus musculus (house mouse) ]

Gene ID: 56744, updated on 3-Oct-2018

Summary

Official Symbol
Pf4provided by MGI
Official Full Name
platelet factor 4provided by MGI
Primary source
MGI:MGI:1888711
See related
Ensembl:ENSMUSG00000029373 Vega:OTTMUSG00000055505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cxcl4; Scyb4
Expression
Biased expression in liver E14 (RPKM 119.8), liver E14.5 (RPKM 114.1) and 13 other tissues See more
Orthologs

Genomic context

See Pf4 in Genome Data Viewer
Location:
5; 5 E1
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (90772435..90773383)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (91201461..91202409)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 5 Neighboring gene pro-platelet basic protein Neighboring gene chemokine (C-X-C motif) ligand 3 Neighboring gene chemokine (C-X-C motif) ligand 15

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
CXCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
defense response IEA
Inferred from Electronic Annotation
more info
 
defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to protozoan ISO
Inferred from Sequence Orthology
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
killing by host of symbiont cells ISO
Inferred from Sequence Orthology
more info
 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytolysis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
negative regulation of megakaryocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage derived foam cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
other organism cytoplasm ISO
Inferred from Sequence Orthology
more info
 
platelet alpha granule ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
symbiont-containing vacuole membrane ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
platelet factor 4
Names
C-X-C motif chemokine 4
PF-4
chemokine (C-X-C motif) ligand 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019932.4NP_064316.1  platelet factor 4 precursor

    See identical proteins and their annotated locations for NP_064316.1

    Status: VALIDATED

    Source sequence(s)
    AK160040, BC061111, BY794492
    Consensus CDS
    CCDS19416.1
    UniProtKB/Swiss-Prot
    Q9Z126
    UniProtKB/TrEMBL
    Q3TVN6, Q6P8R3
    Related
    ENSMUSP00000031320.6, OTTMUSP00000072360, ENSMUST00000031320.7, OTTMUST00000137380
    Conserved Domains (1) summary
    cd00273
    Location:41104
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    90772435..90773383
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 129S1/SvImJ

Genomic

  1. NT_109599.1 Reference GRCm38.p4 129S1/SvImJ

    Range
    53352..54300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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