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Akap10 A kinase (PRKA) anchor protein 10 [ Mus musculus (house mouse) ]

Gene ID: 56697, updated on 26-Sep-2022

Summary

Official Symbol
Akap10provided by MGI
Official Full Name
A kinase (PRKA) anchor protein 10provided by MGI
Primary source
MGI:MGI:1890218
See related
Ensembl:ENSMUSG00000047804 AllianceGenome:MGI:1890218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRKA10; D-AKAP2; D-AKAP-2; 1500031L16Rik; B130049N18Rik
Summary
This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]
Expression
Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
Orthologs
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Genomic context

See Akap10 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61756029..61821134, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61865203..61930308, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene unc-51 like kinase 2 Neighboring gene predicted gene, 23721 Neighboring gene predicted gene 12273

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein localization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein localization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A-kinase anchor protein 10, mitochondrial
Names
dual specificity A kinase-anchoring protein 2
protein kinase A-anchoring protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019921.3NP_064305.2  A-kinase anchor protein 10, mitochondrial precursor

    See identical proteins and their annotated locations for NP_064305.2

    Status: REVIEWED

    Source sequence(s)
    AK049399, AL646042
    Consensus CDS
    CCDS24821.1
    UniProtKB/Swiss-Prot
    O88845, Q8BQL6
    Related
    ENSMUSP00000099710.4, ENSMUST00000102650.10
    Conserved Domains (3) summary
    cd08721
    Location:383503
    RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
    cd08735
    Location:122367
    RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
    cd12804
    Location:618662
    AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61756029..61821134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533814.5XP_006533877.1  A-kinase anchor protein 10, mitochondrial isoform X1

    Conserved Domains (3) summary
    cd08721
    Location:354474
    RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
    cd08735
    Location:93338
    RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
    cd12804
    Location:589633
    AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

RNA

  1. XR_879723.3 RNA Sequence