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Mlycd malonyl-CoA decarboxylase [ Mus musculus (house mouse) ]

Gene ID: 56690, updated on 8-Feb-2024

Summary

Official Symbol
Mlycdprovided by MGI
Official Full Name
malonyl-CoA decarboxylaseprovided by MGI
Primary source
MGI:MGI:1928485
See related
Ensembl:ENSMUSG00000074064 AllianceGenome:MGI:1928485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mcd
Summary
Enables malonyl-CoA decarboxylase activity. Involved in malonyl-CoA catabolic process and positive regulation of fatty acid oxidation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; nervous system; nose; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.4), liver adult (RPKM 25.8) and 28 other tissues See more
Orthologs
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Genomic context

See Mlycd in Genome Data Viewer
Location:
8 E1; 8 67.64 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (120121591..120148577)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (119394852..119421838)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10525 Neighboring gene heat shock factor binding protein 1 Neighboring gene predicted gene 45723 Neighboring gene STARR-positive B cell enhancer ABC_E3809 Neighboring gene predicted gene, 32006 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:121947490-121947599 Neighboring gene STARR-positive B cell enhancer ABC_E2879 Neighboring gene STARR-positive B cell enhancer ABC_E10526 Neighboring gene oxidative stress induced growth inhibitor 1 Neighboring gene N-terminal EF-hand calcium binding protein 2 Neighboring gene predicted gene, 53462

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables malonyl-CoA decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables malonyl-CoA decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables malonyl-CoA decarboxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in malonyl-CoA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in malonyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in malonyl-CoA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fatty acid oxidation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in peroxisomal matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
malonyl-CoA decarboxylase, mitochondrial
NP_001351257.1
NP_064350.2
XP_006531281.1
XP_006531285.1
XP_006531288.1
XP_006531289.1
XP_011246759.1
XP_017168411.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364328.1NP_001351257.1  malonyl-CoA decarboxylase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Conserved Domains (1) summary
    pfam05292
    Location:94365
    MCD; Malonyl-CoA decarboxylase (MCD)
  2. NM_019966.3NP_064350.2  malonyl-CoA decarboxylase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_064350.2

    Status: VALIDATED

    Source sequence(s)
    AC166781
    Consensus CDS
    CCDS22703.1
    UniProtKB/Swiss-Prot
    Q7TNL6, Q99J39
    Related
    ENSMUSP00000095970.5, ENSMUST00000098367.5
    Conserved Domains (1) summary
    pfam05292
    Location:94455
    MCD; Malonyl-CoA decarboxylase (MCD)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    120121591..120148577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248457.4XP_011246759.1  malonyl-CoA decarboxylase, mitochondrial isoform X2

    Conserved Domains (2) summary
    pfam05292
    Location:192315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
  2. XM_017312922.3XP_017168411.1  malonyl-CoA decarboxylase, mitochondrial isoform X4

    Conserved Domains (2) summary
    pfam05292
    Location:192315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
  3. XM_006531222.5XP_006531285.1  malonyl-CoA decarboxylase, mitochondrial isoform X3

    Conserved Domains (2) summary
    pfam05292
    Location:192315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
  4. XM_006531225.5XP_006531288.1  malonyl-CoA decarboxylase, mitochondrial isoform X5

    Conserved Domains (2) summary
    pfam05292
    Location:192315
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
  5. XM_006531226.5XP_006531289.1  malonyl-CoA decarboxylase, mitochondrial isoform X6

    Conserved Domains (2) summary
    pfam05292
    Location:192316
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:94189
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain
  6. XM_006531218.5XP_006531281.1  malonyl-CoA decarboxylase, mitochondrial isoform X1

    Conserved Domains (2) summary
    pfam05292
    Location:174437
    MCD; Malonyl-CoA decarboxylase C-terminal domain
    pfam17408
    Location:105171
    MCD_N; Malonyl-CoA decarboxylase N-terminal domain