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MLYCD malonyl-CoA decarboxylase [ Homo sapiens (human) ]

Gene ID: 23417, updated on 13-Feb-2019

Summary

Official Symbol
MLYCDprovided by HGNC
Official Full Name
malonyl-CoA decarboxylaseprovided by HGNC
Primary source
HGNC:HGNC:7150
See related
Ensembl:ENSG00000103150 MIM:606761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCD
Summary
The product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 24.2), liver (RPKM 11.1) and 24 other tissues See more
Orthologs

Genomic context

See MLYCD in Genome Data Viewer
Location:
16q23.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (83899125..83916182)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (83932720..83962428)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371370 Neighboring gene heat shock factor binding protein 1 Neighboring gene uncharacterized LOC105371372 Neighboring gene uncharacterized LOC105371371

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Peroxisomal lipid metabolism, organism-specific biosystem (from REACTOME)
    Peroxisomal lipid metabolism, organism-specific biosystemIn humans, the catabolism of phytanate, pristanate, and very long chain fatty acids as well as the first four steps of the biosynthesis of plasmalogens are catalyzed by peroxisomal enzymes. Defects i...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Propanoate metabolism, organism-specific biosystem (from KEGG)
    Propanoate metabolism, organism-specific biosystem
    Propanoate metabolism
  • Propanoate metabolism, conserved biosystem (from KEGG)
    Propanoate metabolism, conserved biosystem
    Propanoate metabolism
  • beta-Alanine metabolism, organism-specific biosystem (from KEGG)
    beta-Alanine metabolism, organism-specific biosystem
    beta-Alanine metabolism
  • beta-Alanine metabolism, conserved biosystem (from KEGG)
    beta-Alanine metabolism, conserved biosystem
    beta-Alanine metabolism

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: OSGIN1

Homology

Clone Names

  • MGC59795

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
malonyl-CoA decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
malonyl-CoA decarboxylase activity TAS
Traceable Author Statement
more info
 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
malonyl-CoA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fatty acid oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
 
regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
malonyl-CoA decarboxylase, mitochondrial
Names
malonyl coenzyme A decarboxylase
NP_036345.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009079.1 RefSeqGene

    Range
    5001..22058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012213.3NP_036345.2  malonyl-CoA decarboxylase, mitochondrial

    See identical proteins and their annotated locations for NP_036345.2

    Status: REVIEWED

    Source sequence(s)
    AC009119, BC052592
    Consensus CDS
    CCDS42206.1
    UniProtKB/Swiss-Prot
    O95822
    Related
    ENSP00000262430.4, ENST00000262430.5
    Conserved Domains (1) summary
    pfam05292
    Location:95456
    MCD; Malonyl-CoA decarboxylase (MCD)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    83899125..83916182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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