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Sphk2 sphingosine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 56632, updated on 13-Dec-2022

Summary

Official Symbol
Sphk2provided by MGI
Official Full Name
sphingosine kinase 2provided by MGI
Primary source
MGI:MGI:1861380
See related
Ensembl:ENSMUSG00000057342 AllianceGenome:MGI:1861380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sk2; Spk2
Summary
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in duodenum adult (RPKM 72.1), adrenal adult (RPKM 42.9) and 28 other tissues See more
Orthologs
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Genomic context

See Sphk2 in Genome Data Viewer
Location:
7; 7 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45358887..45367426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45709463..45718002, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene secretory blood group 1 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene D site albumin promoter binding protein Neighboring gene ribosomal protein L18 Neighboring gene family with sequence similarity 83, member E Neighboring gene sperm acrosome associated 4 Neighboring gene sulfotransferase family, cytosolic, 2B, member 1 Neighboring gene predicted gene, 31597

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC102297

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-erythro-sphingosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables D-erythro-sphingosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables D-erythro-sphingosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables D-erythro-sphingosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipid kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphinganine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables sphingosine-1-phosphate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within brain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cellular response to phorbol 13-acetate 12-myristate ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2A-K5 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in histone H2B-K12 acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-13 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mast cell activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphinganine-1-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphinganine-1-phosphate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphinganine-1-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sphingosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sphingosine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingosine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transcription initiation-coupled chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sphingosine kinase 2
NP_001166032.1
NP_064395.2
NP_975009.1
XP_006541075.1
XP_006541076.1
XP_036009169.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172561.1NP_001166032.1  sphingosine kinase 2

    See identical proteins and their annotated locations for NP_001166032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC167242
    Consensus CDS
    CCDS21261.1
    UniProtKB/Swiss-Prot
    Q9DBH6, Q9JIA7
    UniProtKB/TrEMBL
    Q58E38
    Related
    ENSMUSP00000147391.2, ENSMUST00000210060.2
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  2. NM_020011.5NP_064395.2  sphingosine kinase 2

    See identical proteins and their annotated locations for NP_064395.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC167242, AK004951
    Consensus CDS
    CCDS21261.1
    UniProtKB/Swiss-Prot
    Q9DBH6, Q9JIA7
    UniProtKB/TrEMBL
    Q58E38
    Related
    ENSMUSP00000072615.5, ENSMUST00000072836.7
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  3. NM_203280.3NP_975009.1  sphingosine kinase 2

    See identical proteins and their annotated locations for NP_975009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the same protein as variants 2 and 3.
    Source sequence(s)
    AC167242, AK151990, BY256088
    Consensus CDS
    CCDS21261.1
    UniProtKB/Swiss-Prot
    Q9DBH6, Q9JIA7
    UniProtKB/TrEMBL
    Q3U912, Q58E38
    Related
    ENSMUSP00000103366.3, ENSMUST00000107737.11
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45358887..45367426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541013.3XP_006541076.1  sphingosine kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006541076.1

    UniProtKB/Swiss-Prot
    Q9DBH6, Q9JIA7
    UniProtKB/TrEMBL
    Q58E38
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  2. XM_006541012.5XP_006541075.1  sphingosine kinase 2 isoform X1

    See identical proteins and their annotated locations for XP_006541075.1

    UniProtKB/Swiss-Prot
    Q9DBH6, Q9JIA7
    UniProtKB/TrEMBL
    Q58E38
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase
  3. XM_036153276.1XP_036009169.1  sphingosine kinase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9DBH6
    UniProtKB/TrEMBL
    Q58E38
    Conserved Domains (1) summary
    PLN02958
    Location:142608
    PLN02958; diacylglycerol kinase/D-erythro-sphingosine kinase