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AZU1 azurocidin 1 [ Homo sapiens (human) ]

Gene ID: 566, updated on 8-Jul-2021

Summary

Official Symbol
AZU1provided by HGNC
Official Full Name
azurocidin 1provided by HGNC
Primary source
HGNC:HGNC:913
See related
Ensembl:ENSG00000172232 MIM:162815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZU; HBP; NAZC; hHBP; AZAMP; CAP37; HUMAZUR
Summary
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]
Expression
Restricted expression toward bone marrow (RPKM 1256.4) See more
Orthologs
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Genomic context

See AZU1 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (827837..832018)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (827837..832018)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 4745 Neighboring gene phospholipid phosphatase related 3 Neighboring gene microRNA 3187 Neighboring gene proteinase 3 Neighboring gene elastase, neutrophil expressed

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables toxic substance binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling using intracellular calcium source IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular extravasation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in defense response to Gram-negative bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in induction of positive chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in macrophage chemotaxis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microglial cell activation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in monocyte activation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in neutrophil-mediated killing of bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MHC class II biosynthetic process IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in positive regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fractalkine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein kinase C signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vascular permeability NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
azurocidin
Names
cationic antimicrobial protein 37
cationic antimicrobial protein CAP37
heparin-binding protein
neutrophil azurocidin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001700.5NP_001691.1  azurocidin preproprotein

    See identical proteins and their annotated locations for NP_001691.1

    Status: REVIEWED

    Source sequence(s)
    BC093931, BU617927
    Consensus CDS
    CCDS12044.1
    UniProtKB/Swiss-Prot
    P20160
    Related
    ENSP00000233997.1, ENST00000233997.4
    Conserved Domains (1) summary
    cd00190
    Location:27240
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    827837..832018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187622.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    6680..10861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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