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Rgs17 regulator of G-protein signaling 17 [ Mus musculus (house mouse) ]

Gene ID: 56533, updated on 5-Mar-2024

Summary

Official Symbol
Rgs17provided by MGI
Official Full Name
regulator of G-protein signaling 17provided by MGI
Primary source
MGI:MGI:1927469
See related
Ensembl:ENSMUSG00000019775 AllianceGenome:MGI:1927469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rgsz2; 6430507P11Rik
Summary
Predicted to enable GTPase activator activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 5.0), frontal lobe adult (RPKM 4.8) and 8 other tissues See more
Orthologs
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Genomic context

See Rgs17 in Genome Data Viewer
Location:
10 A1; 10 1.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5775663..5872413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5825663..5922412, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene predicted gene, 53609 Neighboring gene STARR-seq mESC enhancer starr_25593 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene F-box protein 5 Neighboring gene predicted gene, 18902 Neighboring gene STARR-seq mESC enhancer starr_25590 Neighboring gene STARR-seq mESC enhancer starr_25589 Neighboring gene STARR-seq mESC enhancer starr_25588 Neighboring gene STARR-seq mESC enhancer starr_25586 Neighboring gene STARR-seq mESC enhancer starr_25585 Neighboring gene STARR-seq mESC enhancer starr_25584 Neighboring gene predicted gene 3213 Neighboring gene tripartite motif-containing 59 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
regulator of G-protein signaling 17
Names
regulator of G-protein signaling Z2
regulator of Gz-selective protein signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161822.1NP_001155294.1  regulator of G-protein signaling 17 isoform 1

    See identical proteins and their annotated locations for NP_001155294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159325, AK030492, AK045770
    Consensus CDS
    CCDS56686.1
    UniProtKB/TrEMBL
    G5E8E0, Q8BR34
    Related
    ENSMUSP00000065825.8, ENSMUST00000064225.14
    Conserved Domains (1) summary
    cl02565
    Location:61217
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_019958.4NP_064342.1  regulator of G-protein signaling 17 isoform 2

    See identical proteins and their annotated locations for NP_064342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC159325, AK030492
    Consensus CDS
    CCDS56685.1
    UniProtKB/Swiss-Prot
    Q543T9, Q9QZB0
    UniProtKB/TrEMBL
    Q8C5F3
    Related
    ENSMUSP00000116291.2, ENSMUST00000131996.8
    Conserved Domains (1) summary
    cl02565
    Location:41197
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    5775663..5872413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512457.5XP_006512520.1  regulator of G-protein signaling 17 isoform X2

    See identical proteins and their annotated locations for XP_006512520.1

    UniProtKB/Swiss-Prot
    Q543T9, Q9QZB0
    UniProtKB/TrEMBL
    Q8C5F3
    Conserved Domains (1) summary
    cl02565
    Location:41197
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. XM_030245185.2XP_030101045.1  regulator of G-protein signaling 17 isoform X1

    UniProtKB/TrEMBL
    G5E8E0, Q8BR34
    Conserved Domains (1) summary
    cl02565
    Location:61217
    RGS; Regulator of G protein signaling (RGS) domain superfamily