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Rgs17 regulator of G-protein signaling 17 [ Mus musculus (house mouse) ]

Gene ID: 56533, updated on 2-Nov-2024

Summary

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Official Symbol
Rgs17provided by MGI
Official Full Name
regulator of G-protein signaling 17provided by MGI
Primary source
MGI:MGI:1927469
See related
Ensembl:ENSMUSG00000019775 AllianceGenome:MGI:1927469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rgsz2; 6430507P11Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of signal transduction. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including neuron projection; nucleus; and synapse. Orthologous to human RGS17 (regulator of G protein signaling 17). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 5.0), frontal lobe adult (RPKM 4.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Rgs17 in Genome Data Viewer
Location:
10 A1; 10 1.91 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5775663..5872413, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5825663..5922412, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25595 Neighboring gene STARR-positive B cell enhancer ABC_E3873 Neighboring gene STARR-positive B cell enhancer ABC_E3872 Neighboring gene predicted gene, 53609 Neighboring gene STARR-seq mESC enhancer starr_25593 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene F-box protein 5 Neighboring gene predicted gene, 18902 Neighboring gene STARR-seq mESC enhancer starr_25590 Neighboring gene STARR-seq mESC enhancer starr_25589 Neighboring gene STARR-seq mESC enhancer starr_25588 Neighboring gene STARR-seq mESC enhancer starr_25586 Neighboring gene STARR-seq mESC enhancer starr_25585 Neighboring gene STARR-seq mESC enhancer starr_25584 Neighboring gene predicted gene 3213 Neighboring gene tripartite motif-containing 59 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SUMO-SIM interactions regulate the activity of RGSZ2 proteins. Garzón J, et al. PLoS One, 2011. PMID 22163035, Free PMC Article
  2. RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway. Garzón J, et al. Antioxid Redox Signal, 2011 Aug 15. PMID 21348811
  3. RGS17/RGSZ2, a novel regulator of Gi/o, Gz, and Gq signaling. Mao H, et al. J Biol Chem, 2004 Jun 18. PMID 15096504
  4. NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors. Rodríguez-Muñoz M, et al. Cell Signal, 2008 Oct. PMID 18652891
  5. The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. Cortés-Montero E, et al. Antioxid Redox Signal, 2019 Sep 1. PMID 31088288, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUMO-SIM interactions regulate the activity of RGSZ2 proteins
    Title: SUMO-SIM interactions regulate the activity of RGSZ2 proteins.
  2. This RGSZ2-dependent regulation of NMDAR activity is relevant to persistent pain disorders associated with heightened NMDAR-mediated glutamate responses and the reduced antinociceptive capacity of opioids.
    Title: RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.
  3. These results indicate that the NMDAR/nNOS cascade, activated via MORs, provide the free zinc ions required for inactive PKCgamma to bind to HINT1/RGSZ complex at the C terminus of the receptor.
    Title: NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 17
Names
regulator of G-protein signaling Z2
regulator of Gz-selective protein signaling 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161822.1 → NP_001155294.1  regulator of G-protein signaling 17 isoform 1

    See identical proteins and their annotated locations for NP_001155294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC159325, AK030492, AK045770
    Consensus CDS
    CCDS56686.1
    UniProtKB/TrEMBL
    G5E8E0, Q8BR34
    Related
    ENSMUSP00000065825.8, ENSMUST00000064225.14
    Conserved Domains (1) summary
    cl02565
    Location:61 → 217
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. NM_019958.4 → NP_064342.1  regulator of G-protein signaling 17 isoform 2

    See identical proteins and their annotated locations for NP_064342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks the exon containing the translation start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC159325, AK030492
    Consensus CDS
    CCDS56685.1
    UniProtKB/Swiss-Prot
    Q543T9, Q9QZB0
    UniProtKB/TrEMBL
    Q8C5F3
    Related
    ENSMUSP00000116291.2, ENSMUST00000131996.8
    Conserved Domains (1) summary
    cl02565
    Location:41 → 197
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    5775663..5872413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512457.5 → XP_006512520.1  regulator of G-protein signaling 17 isoform X2

    See identical proteins and their annotated locations for XP_006512520.1

    UniProtKB/Swiss-Prot
    Q543T9, Q9QZB0
    UniProtKB/TrEMBL
    Q8C5F3
    Conserved Domains (1) summary
    cl02565
    Location:41 → 197
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  2. XM_030245185.2 → XP_030101045.1  regulator of G-protein signaling 17 isoform X1

    UniProtKB/TrEMBL
    G5E8E0, Q8BR34
    Conserved Domains (1) summary
    cl02565
    Location:61 → 217
    RGS; Regulator of G protein signaling (RGS) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZB0.1 GenPept UniProtKB/Swiss-Prot:Q9QZB0

Gene LinkOut

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