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RGS17 regulator of G protein signaling 17 [ Homo sapiens (human) ]

Gene ID: 26575, updated on 24-Nov-2020


Official Symbol
RGS17provided by HGNC
Official Full Name
regulator of G protein signaling 17provided by HGNC
Primary source
See related
Ensembl:ENSG00000091844 MIM:607191
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGSZ2; RGS-17; hRGS17
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues See more

Genomic context

See RGS17 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (153004459..153131284, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153332026..153452389, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene F-box protein 5 Neighboring gene mitochondrial translational release factor 1 like Neighboring gene RNA, 5S ribosomal pseudogene 224 Neighboring gene ribosomal protein L27a pseudogene 6

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
GTPase activity TAS
Traceable Author Statement
more info
protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
response to amphetamine IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
neuron projection IEA
Inferred from Electronic Annotation
more info
nucleus IEA
Inferred from Electronic Annotation
more info
plasma membrane TAS
Traceable Author Statement
more info
synapse IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
regulator of G-protein signaling 17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012419.5NP_036551.3  regulator of G-protein signaling 17

    See identical proteins and their annotated locations for NP_036551.3

    Status: REVIEWED

    Source sequence(s)
    AA902430, AF202257, AL080276, AL356963, BC013117, CK902282
    Consensus CDS
    ENSP00000206262.1, ENST00000206262.2
    Conserved Domains (1) summary
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    153004459..153131284 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010733.1XP_016866222.1  regulator of G-protein signaling 17 isoform X1

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