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TMPRSS15 transmembrane serine protease 15 [ Homo sapiens (human) ]

Gene ID: 5651, updated on 11-Jun-2021

Summary

Official Symbol
TMPRSS15provided by HGNC
Official Full Name
transmembrane serine protease 15provided by HGNC
Primary source
HGNC:HGNC:9490
See related
Ensembl:ENSG00000154646 MIM:606635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ENTK; PRSS7
Summary
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward duodenum (RPKM 404.7) See more
Orthologs
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Genomic context

See TMPRSS15 in Genome Data Viewer
Location:
21q21.1
Exon count:
28
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (18269107..18403806, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (19641433..19776102, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene chondrolectin Neighboring gene ribosomal protein L37 pseudogene 3 Neighboring gene uncharacterized LOC107987296 Neighboring gene MIR548X host gene Neighboring gene microRNA 548x Neighboring gene peptidylprolyl isomerase A pseudogene 22

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Enterokinase deficiency
MedGen: C0268416 OMIM: 226200 GeneReviews: Not available
Compare labs
Genetic variants associated with disordered eating.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133046

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scavenger receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in brush border TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
enteropeptidase
Names
enterokinase catalytic subunit
protease, serine, 7 (enterokinase)
serine protease 7
transmembrane protease, serine 15
NP_002763.3
XP_011527956.1
XP_011527957.1
XP_011527958.1
XP_011527959.1
XP_011527960.1
XP_011527961.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012207.1 RefSeqGene

    Range
    5001..139538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002772.3NP_002763.3  enteropeptidase precursor

    Status: REVIEWED

    Source sequence(s)
    AL078474, AP000455, AP000456
    Consensus CDS
    CCDS13571.1
    Related
    ENSP00000284885.3, ENST00000284885.8
    Conserved Domains (6) summary
    smart00200
    Location:53172
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:678771
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:643677
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:7851016
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:524631
    CUB; CUB domain
    pfam00629
    Location:347503
    MAM; MAM domain, meprin/A5/mu

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    18269107..18403806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529655.1XP_011527957.1  enteropeptidase isoform X1

    See identical proteins and their annotated locations for XP_011527957.1

    Conserved Domains (8) summary
    cd06263
    Location:392547
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:8291059
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:387547
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53195
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:723816
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:688722
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8301061
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:569676
    CUB; CUB domain
  2. XM_011529656.2XP_011527958.1  enteropeptidase isoform X1

    See identical proteins and their annotated locations for XP_011527958.1

    Conserved Domains (8) summary
    cd06263
    Location:392547
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:8291059
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:387547
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53195
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:723816
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:688722
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8301061
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:569676
    CUB; CUB domain
  3. XM_011529658.2XP_011527960.1  enteropeptidase isoform X3

    Conserved Domains (8) summary
    cd06263
    Location:365520
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:8021032
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:360520
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53199
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:696789
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:661695
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8031034
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:542649
    CUB; CUB domain
  4. XM_011529657.2XP_011527959.1  enteropeptidase isoform X2

    Conserved Domains (8) summary
    cd06263
    Location:377532
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:8141044
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:372532
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53202
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:708801
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:673707
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8151046
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:554661
    CUB; CUB domain
  5. XM_011529654.2XP_011527956.1  enteropeptidase isoform X1

    See identical proteins and their annotated locations for XP_011527956.1

    Conserved Domains (8) summary
    cd06263
    Location:392547
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:8291059
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:387547
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53195
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:723816
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:688722
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8301061
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:569676
    CUB; CUB domain
  6. XM_011529659.1XP_011527961.1  enteropeptidase isoform X4

    Conserved Domains (8) summary
    cd06263
    Location:362517
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00020
    Location:7991029
    Tryp_SPc; Trypsin-like serine protease
    smart00137
    Location:357517
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00200
    Location:53165
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00202
    Location:693786
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:658692
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8001031
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00431
    Location:539646
    CUB; CUB domain
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