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Snd1 staphylococcal nuclease and tudor domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 56463, updated on 3-Nov-2024

Summary

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Official Symbol
Snd1provided by MGI
Official Full Name
staphylococcal nuclease and tudor domain containing 1provided by MGI
Primary source
MGI:MGI:1929266
See related
Ensembl:ENSMUSG00000001424 AllianceGenome:MGI:1929266
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tudor-SN
Summary
Predicted to enable RISC complex binding activity; RNA binding activity; and RNA endonuclease activity. Predicted to be involved in mRNA catabolic process; miRNA catabolic process; and regulation of cell cycle process. Located in dense body and nucleus. Is expressed in several structures, including central nervous system; early conceptus; limb mesenchyme; reproductive system; and sensory organ. Orthologous to human SND1 (staphylococcal nuclease and tudor domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 40.7), ovary adult (RPKM 37.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Snd1 in Genome Data Viewer
Location:
6 A3.3; 6 11.99 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (28480332..28935161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (28480337..28935162)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene Pax4 5' regulatory region Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:28430124-28430311 Neighboring gene fascin actin-bundling protein 3 Neighboring gene paired box 4 Neighboring gene STARR-seq mESC enhancer starr_15418 Neighboring gene leucine rich repeat containing 4 Neighboring gene STARR-seq mESC enhancer starr_15424 Neighboring gene STARR-seq mESC enhancer starr_15426 Neighboring gene predicted gene, 53277 Neighboring gene uncharacterized LOC118567373 Neighboring gene predicted gene, 38779 Neighboring gene predicted gene, 40357 Neighboring gene microRNA 129-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP. Su C, et al. Cell Commun Signal, 2024 Jun 28. PMID 38943195, Free PMC Article
  2. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Fu X, et al. Cell Death Differ, 2018 Sep. PMID 29459768, Free PMC Article
  3. Global Tudor-SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance. Wang X, et al. FASEB J, 2019 Mar. PMID 30521378
  4. Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation. Yao X, et al. Biochem Biophys Res Commun, 2019 Jun 30. PMID 31084926
  5. Expression analysis of Tudor-SN protein in mouse tissues. Fashe T, et al. Tissue Cell, 2013 Feb. PMID 23068188

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SND1, a novel co-activator of HIF1alpha, promotes tumor initiation in PyMT-induced breast tumor.
    Title: SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor.
  2. Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
    Title: Vascular injury activates the ELK1/SND1/SRF pathway to promote vascular smooth muscle cell proliferative phenotype and neointimal hyperplasia.
  3. SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
    Title: SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer.
  4. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma.
    Title: Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma.
  5. FXR1 impedes the development of osteoarthritis by targeting SND1.
    Title: FXR1 impedes the development of osteoarthritis by targeting SND1.
  6. SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1beta-stimulated chondrocytes via PINK1/BECN1 pathway.
    Title: SND1 aggravates mitochondrial damage, apoptosis and extracellular matrix degradation in IL-1β-stimulated chondrocytes via PINK1/BECN1 pathway.
  7. Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
    Title: Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.
  8. Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes.
    Title: Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes.
  9. The current findings reveal SND1 as a new regulatory factor in DNA damage response.
    Title: Protective effects of SND1 in retinal photoreceptor cell damage induced by ionizing radiation.
  10. The loss-of-function of Tudor-SN attenuated the enrichment of SMARCA5, GCN5 and acetylation of histone H3 (acH3) at DNA break sites and abolished chromatin relaxation; as a result, the cells exhibited DNA repair and cell survival deficiency.
    Title: Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RISC complex binding IEA
Inferred from Electronic Annotation
more info
  
enables RISC complex binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNAi effector complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dense body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
staphylococcal nuclease domain-containing protein 1
Names
100 kDa coactivator
p100 co-activator
NP_062750.2
XP_006505205.1
XP_030111373.1
XP_030111374.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019776.2 → NP_062750.2  staphylococcal nuclease domain-containing protein 1

    See identical proteins and their annotated locations for NP_062750.2

    Status: VALIDATED

    Source sequence(s)
    AB021491, AC072048, AK034914, BB613775, BM944959
    Consensus CDS
    CCDS19953.1
    UniProtKB/Swiss-Prot
    Q3TT46, Q78PY7, Q922L5, Q9R0S1
    UniProtKB/TrEMBL
    Q3TW51, Q3UZI3
    Related
    ENSMUSP00000001460.7, ENSMUST00000001460.14
    Conserved Domains (5) summary
    smart00333
    Location:728 → 784
    TUDOR; Tudor domain
    smart00318
    Location:21 → 166
    SNc; Staphylococcal nuclease homologues
    cd00175
    Location:26 → 166
    SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
    pfam00567
    Location:677 → 799
    TUDOR; Tudor domain
    cl00140
    Location:844 → 895
    SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    28480332..28935161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505142.4 → XP_006505205.1  staphylococcal nuclease domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006505205.1

    UniProtKB/TrEMBL
    Q3TJ56
    Related
    ENSMUSP00000128737.2, ENSMUST00000167201.2
    Conserved Domains (3) summary
    smart00318
    Location:21 → 166
    SNc; Staphylococcal nuclease homologues
    cd00175
    Location:350 → 496
    SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
    cl29560
    Location:525 → 593
    SNc; Staphylococcal nuclease homologues

  2. XM_030255513.1 → XP_030111373.1  staphylococcal nuclease domain-containing protein 1 isoform X2

    Conserved Domains (3) summary
    smart00318
    Location:127 → 262
    SNc; Staphylococcal nuclease homologues
    pfam00567
    Location:286 → 401
    TUDOR; Tudor domain
    cl00140
    Location:1 → 98
    SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.

  3. XM_030255514.1 → XP_030111374.1  staphylococcal nuclease domain-containing protein 1 isoform X3

    Conserved Domains (3) summary
    smart00318
    Location:98 → 233
    SNc; Staphylococcal nuclease homologues
    pfam00567
    Location:257 → 372
    TUDOR; Tudor domain
    cl00140
    Location:19 → 69
    SNc; Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78PY7.1 GenPept UniProtKB/Swiss-Prot:Q78PY7

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