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Orc6 origin recognition complex, subunit 6 [ Mus musculus (house mouse) ]

Gene ID: 56452, updated on 30-Apr-2024

Summary

Official Symbol
Orc6provided by MGI
Official Full Name
origin recognition complex, subunit 6provided by MGI
Primary source
MGI:MGI:1929285
See related
Ensembl:ENSMUSG00000031697 AllianceGenome:MGI:1929285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Orc6l; 6720420I10Rik
Summary
Predicted to enable DNA binding activity. Acts upstream of or within DNA-dependent DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including brain ventricular layer; early conceptus; jaw; liver lobe; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 33.8), CNS E11.5 (RPKM 28.8) and 21 other tissues See more
Orthologs
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Genomic context

See Orc6 in Genome Data Viewer
Location:
8 C3; 8 41.61 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86026261..86034908)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85299632..85308279)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily C member 19 Neighboring gene STARR-seq mESC enhancer starr_22152 Neighboring gene VPS35 retromer complex component Neighboring gene STARR-positive B cell enhancer ABC_E9120 Neighboring gene predicted gene, 22336 Neighboring gene myosin light chain kinase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC91038

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA-templated DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear origin of replication recognition complex ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear origin of replication recognition complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of origin recognition complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
origin recognition complex subunit 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163791.1NP_001157263.1  origin recognition complex subunit 6 isoform b

    See identical proteins and their annotated locations for NP_001157263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC134854, AK078405, AK163256, BF661105, BP771997
    Consensus CDS
    CCDS52623.1
    UniProtKB/TrEMBL
    Q3TQX1
    Related
    ENSMUSP00000126925.2, ENSMUST00000170141.3
    Conserved Domains (2) summary
    cd11583
    Location:18110
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    cd16075
    Location:135183
    ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6
  2. NM_019716.2NP_062690.2  origin recognition complex subunit 6 isoform a

    See identical proteins and their annotated locations for NP_062690.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC134854, AK078405, AK163256, BC080739, BF661105, BP771997
    Consensus CDS
    CCDS22497.1
    UniProtKB/Swiss-Prot
    Q9WUJ8
    UniProtKB/TrEMBL
    Q66JV6
    Related
    ENSMUSP00000034132.6, ENSMUST00000034132.13
    Conserved Domains (3) summary
    cd11583
    Location:94186
    Orc6_mid; Middle domain of the origin recognition complex subunit 6
    pfam05460
    Location:694
    ORC6; Origin recognition complex subunit 6 (ORC6)
    cd16075
    Location:211259
    ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

RNA

  1. NR_028268.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134854, AK078405, AK163256, BC080739, BF661105, BP771997

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    86026261..86034908
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)