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Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit [ Mus musculus (house mouse) ]

Gene ID: 56451, updated on 27-Feb-2024

Summary

Official Symbol
Suclg1provided by MGI
Official Full Name
succinate-CoA ligase, GDP-forming, alpha subunitprovided by MGI
Primary source
MGI:MGI:1927234
See related
Ensembl:ENSMUSG00000052738 AllianceGenome:MGI:1927234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sucla1; 1500000I01Rik
Summary
Predicted to enable GDP binding activity; succinate-CoA ligase (ADP-forming) activity; and succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 105.3), heart adult (RPKM 103.6) and 28 other tissues See more
Orthologs
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Genomic context

See Suclg1 in Genome Data Viewer
Location:
6 C1; 6 32.4 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (73225488..73253890)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (73248505..73276907)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 6 Neighboring gene predicted gene, 24533 Neighboring gene STARR-seq mESC enhancer starr_16331 Neighboring gene STARR-positive B cell enhancer mm9_chr6:73171622-73171923 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:73198236-73198345 Neighboring gene predicted gene, 40377 Neighboring gene predicted gene, 38834 Neighboring gene predicted gene, 40378 Neighboring gene STARR-seq mESC enhancer starr_16336 Neighboring gene olfactory receptor family 6 subfamily G member 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinate-CoA ligase (ADP-forming) activity ISO
Inferred from Sequence Orthology
more info
 
enables succinate-CoA ligase (GDP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables succinate-CoA ligase (GDP-forming) activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in succinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in succinyl-CoA metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Names
SCS-alpha
succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
succinyl-CoA synthetase subunit alpha
NP_063932.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019879.3NP_063932.2  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_063932.2

    Status: VALIDATED

    Source sequence(s)
    AI840979, AK005080, BY061062
    Consensus CDS
    CCDS20246.2
    UniProtKB/Swiss-Prot
    Q8C2C3, Q9DBA3, Q9DCI8, Q9WUM5
    Related
    ENSMUSP00000065113.7, ENSMUST00000064740.9
    Conserved Domains (1) summary
    PTZ00187
    Location:19344
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    73225488..73253890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)