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SUCLG1 succinate-CoA ligase GDP/ADP-forming subunit alpha [ Homo sapiens (human) ]

Gene ID: 8802, updated on 27-Nov-2019

Summary

Official Symbol
SUCLG1provided by HGNC
Official Full Name
succinate-CoA ligase GDP/ADP-forming subunit alphaprovided by HGNC
Primary source
HGNC:HGNC:11449
See related
Ensembl:ENSG00000163541 MIM:611224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALPHA; MTDPS9; SUCLA1
Summary
This gene encodes the alpha subunit of the heterodimeric enzyme succinate coenzyme A ligase. This enzyme is targeted to the mitochondria and catalyzes the conversion of succinyl CoA and ADP or GDP to succinate and ATP or GTP. Mutations in this gene are the cause of the metabolic disorder fatal infantile lactic acidosis and mitochondrial DNA depletion. [provided by RefSeq, Feb 2010]
Expression
Broad expression in kidney (RPKM 188.3), duodenum (RPKM 98.6) and 25 other tissues See more
Orthologs

Genomic context

See SUCLG1 in Genome Data Viewer
Location:
2p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (84423528..84459280, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (84650647..84686586, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 pseudogene 1 Neighboring gene uncharacterized LOC107985905 Neighboring gene FUN14 domain containing 2 pseudogene 2 Neighboring gene dynein axonemal heavy chain 6 Neighboring gene uncharacterized LOC107985906 Neighboring gene double homeobox A pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of succinate-CoA ligase, alpha subunit (SUCLG1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21114, FLJ43513

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cofactor binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
succinate-CoA ligase (ADP-forming) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate-CoA ligase (GDP-forming) activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
Names
SCS-alpha
succinate-CoA ligase alpha subunit
succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial
succinyl-CoA synthetase subunit alpha
NP_003840.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016755.1 RefSeqGene

    Range
    5183..40935
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003849.4NP_003840.2  succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003840.2

    Status: REVIEWED

    Source sequence(s)
    AC096770, BC000504, BP194715, BQ774501
    Consensus CDS
    CCDS1967.2
    UniProtKB/Swiss-Prot
    P53597
    Related
    ENSP00000377446.2, ENST00000393868.7
    Conserved Domains (3) summary
    PTZ00187
    Location:19344
    PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional
    pfam02629
    Location:53146
    CoA_binding; CoA binding domain
    cl22543
    Location:199324
    Ligase_CoA; CoA-ligase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    84423528..84459280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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