Tspan3 tetraspanin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tspan3provided by MGI
Official Full Name: tetraspanin 3provided by MGI
Primary source: MGI:MGI:1928098
See related: Ensembl:ENSMUSG00000032324 AllianceGenome:MGI:1928098
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TM4-A; Tm4sf8; 1700055K04Rik
Summary: Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including axial skeleton; cranium; gonad; intestine; and sensory organ. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 234.7), duodenum adult (RPKM 179.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9; 9 B

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (56043168..56068354, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (56135884..56161070, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions.
Title: Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions.
Tspan3 is a central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Title: Tetraspanin 3: A central endocytic membrane component regulating the expression of ADAM10, presenilin and the amyloid precursor protein.
Tspan3 is an important regulator of aggressive leukemias.
Title: Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Endonuclease-mediated (1)

General gene information

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Homology

Homologs of the Tspan3 gene: The Tspan3 gene is conserved in human, chimpanzee, Rhesus monkey, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 469 organisms have orthologs with human gene Tspan3
Orthologs

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tetraspanin-3

Names: H41D4 protein; OAP-1; OSP-associated protein 1; tetraspanin TM4-A homolog; transmembrane 4 superfamily member 8

NP_062767.3

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019793.3 → NP_062767.3 tetraspanin-3

See identical proteins and their annotated locations for NP_062767.3

Status: VALIDATED

Source sequence(s)

AK159418, BB855376, BC043072

Consensus CDS

CCDS23207.1

UniProtKB/Swiss-Prot

Q9EQG4, Q9QY33

UniProtKB/TrEMBL

A0A6P5QHD2, A0A8C6GS82, Q545L1, Q80XR4

Related

ENSMUSP00000034876.9, ENSMUST00000034876.10

Conserved Domains (2) summary

cd03163
Location:104 → 210

TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

pfam00335
Location:9 → 232

Tetraspannin; Tetraspanin family