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Tspan3 tetraspanin 3 [ Mus musculus (house mouse) ]

Gene ID: 56434, updated on 12-May-2024

Summary

Official Symbol
Tspan3provided by MGI
Official Full Name
tetraspanin 3provided by MGI
Primary source
MGI:MGI:1928098
See related
Ensembl:ENSMUSG00000032324 AllianceGenome:MGI:1928098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TM4-A; Tm4sf8; 1700055K04Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including axial skeleton; cranium; gonad; intestine; and sensory organ. Orthologous to human TSPAN3 (tetraspanin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 234.7), duodenum adult (RPKM 179.1) and 24 other tissues See more
Orthologs
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Genomic context

See Tspan3 in Genome Data Viewer
Location:
9 B; 9 30.13 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (56043168..56068354, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (56135884..56161070, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:55889495-55889796 Neighboring gene STARR-positive B cell enhancer mm9_chr9:55923089-55923390 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55937639-55937826 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55938770-55938923 Neighboring gene reticulocalbin 2 Neighboring gene STARR-positive B cell enhancer ABC_E10547 Neighboring gene STARR-seq mESC enhancer starr_24202 Neighboring gene proline-serine-threonine phosphatase-interacting protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:55994441-55994594 Neighboring gene STARR-positive B cell enhancer ABC_E6737 Neighboring gene pseudopodium-enriched atypical kinase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:56112222-56112523 Neighboring gene pseudopodium-enriched atypical kinase 1, opposite strand Neighboring gene STARR-seq mESC enhancer starr_24203 Neighboring gene STARR-seq mESC enhancer starr_24204 Neighboring gene STARR-positive B cell enhancer ABC_E1385 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266337-56266490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:56266643-56266962 Neighboring gene high mobility group 20A Neighboring gene ubiquitin-conjugating enzyme E2S, retrotransposed

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 

General protein information

Preferred Names
tetraspanin-3
Names
H41D4 protein
OAP-1
OSP-associated protein 1
tetraspanin TM4-A homolog
transmembrane 4 superfamily member 8
NP_062767.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019793.3NP_062767.3  tetraspanin-3

    See identical proteins and their annotated locations for NP_062767.3

    Status: VALIDATED

    Source sequence(s)
    AK159418, BB855376, BC043072
    Consensus CDS
    CCDS23207.1
    UniProtKB/Swiss-Prot
    Q9EQG4, Q9QY33
    UniProtKB/TrEMBL
    Q3THL4, Q3TVZ0, Q3TXC6, Q545L1, Q80XR4
    Related
    ENSMUSP00000034876.9, ENSMUST00000034876.10
    Conserved Domains (2) summary
    cd03163
    Location:104210
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9232
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    56043168..56068354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)