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TSPAN3 tetraspanin 3 [ Homo sapiens (human) ]

Gene ID: 10099, updated on 15-Jun-2019

Summary

Official Symbol
TSPAN3provided by HGNC
Official Full Name
tetraspanin 3provided by HGNC
Primary source
HGNC:HGNC:17752
See related
Ensembl:ENSG00000140391 MIM:613134
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM4-A; TM4SF8; TSPAN-3
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in fat (RPKM 113.6), colon (RPKM 109.2) and 25 other tissues See more
Orthologs

Genomic context

See TSPAN3 in Genome Data Viewer
Location:
15q24.3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (77044017..77071228, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (77336359..77363570, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370904 Neighboring gene keratin 8 pseudogene 23 Neighboring gene proline-serine-threonine phosphatase interacting protein 1 Neighboring gene pseudopodium enriched atypical kinase 1 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 27 Neighboring gene long intergenic non-protein coding RNA 597

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tetraspanin-3
Names
tetraspan 3
tetraspan TM4SF
tetraspanin TM4-A
transmembrane 4 superfamily member 8
NP_001161884.1
NP_005715.1
NP_944492.1
XP_016877346.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168412.2NP_001161884.1  tetraspanin-3 isoform 3

    See identical proteins and their annotated locations for NP_001161884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AA554982, AC090181, AK298157, KF510412
    Consensus CDS
    CCDS53963.1
    UniProtKB/Swiss-Prot
    O60637
    Related
    ENSP00000407243.3, ENST00000424443.7
    Conserved Domains (1) summary
    cd03163
    Location:40146
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  2. NM_005724.6NP_005715.1  tetraspanin-3 isoform 1

    See identical proteins and their annotated locations for NP_005715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA554982, AC090181, BC011206, KF510412
    Consensus CDS
    CCDS10292.1
    UniProtKB/Swiss-Prot
    O60637
    Related
    ENSP00000267970.4, ENST00000267970.8
    Conserved Domains (1) summary
    cd03163
    Location:104210
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
  3. NM_198902.3NP_944492.1  tetraspanin-3 isoform 2

    See identical proteins and their annotated locations for NP_944492.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA554982, AC090181, AK075482, KF510412
    Consensus CDS
    CCDS10293.1
    UniProtKB/Swiss-Prot
    O60637
    Related
    ENSP00000341329.2, ENST00000346495.6
    Conserved Domains (1) summary
    cd03163
    Location:84185
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    77041404..77071109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021857.1XP_016877346.1  tetraspanin-3 isoform X1

    Conserved Domains (1) summary
    cd03163
    Location:65171
    TM4SF8_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
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