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Adar adenosine deaminase, RNA-specific [ Mus musculus (house mouse) ]

Gene ID: 56417, updated on 2-Nov-2024

Summary

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Official Symbol
Adarprovided by MGI
Official Full Name
adenosine deaminase, RNA-specificprovided by MGI
Primary source
MGI:MGI:1889575
See related
Ensembl:ENSMUSG00000027951 AllianceGenome:MGI:1889575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adar1; DRADA; mZaADAR; Adar1p110; Adar1p150
Summary
Predicted to enable double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Involved in several processes, including adenosine to inosine editing; negative regulation of protein kinase activity by regulation of protein phosphorylation; and positive regulation of viral genome replication. Acts upstream of or within several processes, including hematopoietic stem cell homeostasis; hemopoiesis; and regulation of gene expression. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study Aicardi-Goutieres syndrome. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome; Human papillomavirus infectious disease; dyschromatosis symmetrica hereditaria; and liver cirrhosis. Orthologous to human ADAR (adenosine deaminase RNA specific). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cortex adult (RPKM 21.4), cerebellum adult (RPKM 21.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Adar in Genome Data Viewer
Location:
3 F1; 3 39.19 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89622321..89660756)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89714469..89753455)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene STARR-seq mESC enhancer starr_08246 Neighboring gene STARR-seq mESC enhancer starr_08247 Neighboring gene STARR-seq mESC enhancer starr_08249 Neighboring gene STARR-positive B cell enhancer ABC_E4555 Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2082 Neighboring gene cholinergic receptor nicotinic beta 2 subunit Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. [Expression of ADAR1 isoforms in murine acute T-ALL leukemia model]. Ma CH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2011 Jun. PMID 21729523
  2. The mRNA expression differences of RNA editing enzymes in differentiated and undifferentiated NG108-15 cells. Sukma M, et al. J Pharmacol Sci, 2005 Aug. PMID 16082172
  3. ADAR1 Prevents Autoinflammatory Processes in the Heart Mediated by IRF7. Garcia-Gonzalez C, et al. Circ Res, 2022 Sep 16. PMID 36000401
  4. RNA-Editing Enzyme ADAR1 p150 Isoform Is Critical for Germinal Center B Cell Response. Li Y, et al. J Immunol, 2022 Sep 15. PMID 35977796
  5. RNA adenosine deaminase (ADAR1) alleviates high-fat diet-induced nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. Xiang R, et al. Lab Invest, 2022 Oct. PMID 35690649

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury.
    Title: ADAR1 regulates macrophage polarization and is protective against liver ischemia and reperfusion injury.
  2. ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.
    Title: ADAR1 protects pulmonary macrophages from sepsis-induced pyroptosis and lung injury through miR-21/A20 signaling.
  3. Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
    Title: Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
  4. ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
    Title: ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation.
  5. ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
    Title: ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis.
  6. Generation of a new Adar1p150 [-/-] mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.
    Title: Generation of a new Adar1p150 (-/-) mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis.
  7. ADAR1 Zalpha domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
    Title: ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing.
  8. RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
    Title: RNA editing of AZIN1 coding sites is catalyzed by ADAR1 p150 after splicing.
  9. An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa.
    Title: An essential role of adenosine deaminase acting on RNA 1 in coeliac disease mucosa.
  10. The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms.
    Title: The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms.
Submit: New GeneRIF Correction See all GeneRIFs (99)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables left-handed Z-DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RISC complex assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenosine to inosine editing IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenosine to inosine editing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within base conversion or substitution editing ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within definitive hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within miRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of post-transcriptional gene silencing by regulatory ncRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within pre-miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
  
involved_in response to interferon-alpha ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within somatic diversification of immune receptors via somatic mutation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of supraspliceosomal complex ISO
Inferred from Sequence Orthology
more info
  
part_of supraspliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
double-stranded RNA-specific adenosine deaminase
Names
RNA adenosine deaminase 1
RNA-specific adenosine deaminase p110 form
RNA-specific adenosine deaminase p150 form
NP_001033676.2
NP_001139768.1
NP_001344887.1
NP_001397587.1
NP_001397588.1
NP_001397589.1
NP_001397590.1
NP_001397591.1
NP_001397592.1
NP_001397593.1
NP_062629.3
XP_006501816.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038587.5 → NP_001033676.2  double-stranded RNA-specific adenosine deaminase isoform 2

    See identical proteins and their annotated locations for NP_001033676.2

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    Consensus CDS
    CCDS17514.1
    UniProtKB/TrEMBL
    Q3UH31
    Related
    ENSMUSP00000096525.3, ENSMUST00000098924.9
    Conserved Domains (5) summary
    smart00552
    Location:540 → 923
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cl02659
    Location:1 → 64
    z-alpha; Adenosine deaminase z-alpha domain
    cd19913
    Location:207 → 277
    DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
    cd19915
    Location:426 → 496
    DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    cl00054
    Location:318 → 388
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily

  2. NM_001146296.2 → NP_001139768.1  double-stranded RNA-specific adenosine deaminase isoform 3

    See identical proteins and their annotated locations for NP_001139768.1

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    Consensus CDS
    CCDS50963.1
    UniProtKB/Swiss-Prot
    O70375, Q80UZ6, Q8C222, Q99MU2, Q99MU3, Q99MU4, Q99MU7
    UniProtKB/TrEMBL
    Q4FJS9
    Related
    ENSMUSP00000103028.3, ENSMUST00000107405.6
    Conserved Domains (4) summary
    smart00358
    Location:457 → 522
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:788 → 1171
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    pfam02295
    Location:137 → 203
    z-alpha; Adenosine deaminase z-alpha domain
    cl02659
    Location:248 → 312
    z-alpha; Adenosine deaminase z-alpha domain

  3. NM_001357958.2 → NP_001344887.1  double-stranded RNA-specific adenosine deaminase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    UniProtKB/TrEMBL
    Q4FJS9
    Conserved Domains (4) summary
    smart00358
    Location:496 → 561
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:827 → 1210
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    pfam02295
    Location:176 → 242
    z-alpha; Adenosine deaminase z-alpha domain
    cl02659
    Location:287 → 351
    z-alpha; Adenosine deaminase z-alpha domain

  4. NM_001410658.1 → NP_001397587.1  double-stranded RNA-specific adenosine deaminase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364

  5. NM_001410659.1 → NP_001397588.1  double-stranded RNA-specific adenosine deaminase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364

  6. NM_001410660.1 → NP_001397589.1  double-stranded RNA-specific adenosine deaminase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364

  7. NM_001410661.1 → NP_001397590.1  double-stranded RNA-specific adenosine deaminase isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364

  8. NM_001410662.1 → NP_001397591.1  double-stranded RNA-specific adenosine deaminase isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    Related
    ENSMUSP00000113453.2, ENSMUST00000118341.6

  9. NM_001410663.1 → NP_001397592.1  double-stranded RNA-specific adenosine deaminase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364

  10. NM_001410664.1 → NP_001397593.1  double-stranded RNA-specific adenosine deaminase isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    Related
    ENSMUSP00000112969.2, ENSMUST00000121094.8

  11. NM_019655.4 → NP_062629.3  double-stranded RNA-specific adenosine deaminase isoform 1

    See identical proteins and their annotated locations for NP_062629.3

    Status: VALIDATED

    Source sequence(s)
    AC102392, AC166364
    Consensus CDS
    CCDS17513.1
    UniProtKB/TrEMBL
    Q4FJS9
    Related
    ENSMUSP00000029563.9, ENSMUST00000029563.14
    Conserved Domains (4) summary
    smart00358
    Location:457 → 522
    DSRM; Double-stranded RNA binding motif
    smart00552
    Location:762 → 1145
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    pfam02295
    Location:137 → 203
    z-alpha; Adenosine deaminase z-alpha domain
    cl02659
    Location:248 → 312
    z-alpha; Adenosine deaminase z-alpha domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89622321..89660756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501753.5 → XP_006501816.3  double-stranded RNA-specific adenosine deaminase isoform X1

    UniProtKB/TrEMBL
    Q4FJS9
    Conserved Domains (6) summary
    smart00552
    Location:816 → 1199
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    pfam02295
    Location:191 → 257
    z-alpha; Adenosine deaminase z-alpha domain
    cl02659
    Location:302 → 366
    z-alpha; Adenosine deaminase z-alpha domain
    cd19913
    Location:509 → 579
    DSRM_DRADA_rpt1; first double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA)
    cd19915
    Location:728 → 798
    DSRM_DRADA_rpt3; third double-stranded RNA binding motif of double-stranded RNA-specific adenosine deaminase (DRADA) and similar proteins
    cl00054
    Location:620 → 690
    DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MU3.2 GenPept UniProtKB/Swiss-Prot:Q99MU3

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