Pdlim5 PDZ and LIM domain 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdlim5provided by MGI
Official Full Name: PDZ and LIM domain 5provided by MGI
Primary source: MGI:MGI:1927489
See related: Ensembl:ENSMUSG00000028273 AllianceGenome:MGI:1927489
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Enh; LIM; Enh1; Enh2; Enh3; 1110001A05Rik
Summary: Predicted to enable actin binding activity; muscle alpha-actinin binding activity; and protein kinase C binding activity. Predicted to be involved in actin cytoskeleton organization; cell growth involved in cardiac muscle cell development; and regulation of synapse organization. Located in Z disc. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb mesenchyme; and musculoskeletal system. Used to study dilated cardiomyopathy. Orthologous to human PDLIM5 (PDZ and LIM domain 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 41.4), bladder adult (RPKM 16.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H1; 3 66.69 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (141945346..142101480, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (142239585..142395719, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
Title: Endothelial Scaffolding Protein ENH (Enigma Homolog Protein) Promotes PHLPP2 (Pleckstrin Homology Domain and Leucine-Rich Repeat Protein Phosphatase 2)-Mediated Dephosphorylation of AKT1 and eNOS (Endothelial NO Synthase) Promoting Vascular Remodeling.
These results reveal a E2F1/miR-17-92/ENH1/Id1 regulatory axis during myogenesis.
Title: MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis.
Collectively, our results suggest that ENH1 plays an important role in the activation of myogenesis through the repression of Id2 activity.
Title: Scaffold protein enigma homolog 1 overcomes the repression of myogenesis activation by inhibitor of DNA binding 2.
Cypher and ENH redundantly play an essential role in sustaining Z-line structure from the earliest stages of cardiac function, and are redundantly required to maintain normal embryonic heart function and embryonic viability.
Title: Cypher and Enigma homolog protein are essential for cardiac development and embryonic survival.
PDLIM5 is involved in psychiatric disorders, including mood disorders
Title: Experimental evidence for the involvement of PDLIM5 in mood disorders in hetero knockout mice.
ENH1 with multiple protein-protein interaction modules is essential for differentiation of striated muscles, whereas ectopic expression of LIM domain-less ENH disrupts normal muscle differentiation.
Title: Enigma homolog 1 promotes myogenic gene expression and differentiation of C2C12 cells.
coordinated and stepwise splicing transitions result in the production of specific ENH transcripts in mature striated muscles.
Title: Splicing transitions of the anchoring protein ENH during striated muscle development.
Deletion of ENH leads to destabilization of this protein complex and dilated cardiomyopathy in mice.
Title: Loss of enigma homolog protein results in dilated cardiomyopathy.
Antagonistic splice variants of enigma may play a central role in the adaptive changes of the link between mechanical stress-sensing and signalling occurring during embryonic development and/or heart hypertrophy.
Title: Splice variants of enigma homolog, differentially expressed during heart development, promote or prevent hypertrophy.
ENH is a restraining factor of the oncogenic activity of inhibitor of DNA binding 2 proteins in neural tumors
Title: The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI987914 (e-PCR)
- UniSTS:178944

Pdlim5 (e-PCR), detects polymorphism
- UniSTS:526940

C87059 (e-PCR)
- UniSTS:207569

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actinin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables muscle alpha-actinin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle structure development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
part_of filamentous actin	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: PDZ and LIM domain protein 5

Names: enigma homolog; enigma-like PDZ and LIM domains protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190852.2 → NP_001177781.1 PDZ and LIM domain protein 5 isoform ENH1e

See identical proteins and their annotated locations for NP_001177781.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) represents the longest transcript and it encodes the longest protein (isoform ENH1e).

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS80038.1

UniProtKB/TrEMBL

D9J302

Related

ENSMUSP00000142737.2, ENSMUST00000195975.5

Conserved Domains (5) summary

cd09453
Location:438 → 489

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15229
Location:303 → 413

POM121; POM121 family

pfam15936
Location:105 → 185

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:556 → 610

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001190853.2 → NP_001177782.1 PDZ and LIM domain protein 5 isoform ENH4

See identical proteins and their annotated locations for NP_001177782.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has multiple differences, compared to variant 4. The resulting protein (isoform ENH4) has a shorter and distinct C-terminus when compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS57258.1

UniProtKB/TrEMBL

Q9CRA2

Related

ENSMUSP00000087595.6, ENSMUST00000090134.12

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:100 → 171

DUF4749; Domain of unknown function (DUF4749)
NM_001190854.2 → NP_001177783.1 PDZ and LIM domain protein 5 isoform ENH1b

See identical proteins and their annotated locations for NP_001177783.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks three alternate exons, compared to variant 4. The resulting protein (isoform ENH1b) is shorter, compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS80035.1

UniProtKB/TrEMBL

D9J2Z9, Q2Q7P0

Related

ENSMUSP00000142899.2, ENSMUST00000198381.5

Conserved Domains (5) summary

PHA03381
Location:136 → 323

PHA03381; tegument protein VP22; Provisional

cd09453
Location:306 → 357

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 185

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:424 → 478

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001190855.2 → NP_001177784.1 PDZ and LIM domain protein 5 isoform ENH1c

See identical proteins and their annotated locations for NP_001177784.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two alternate exons, compared to variant 4. The resulting protein (isoform ENH1c) is shorter when it is compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS80036.1

UniProtKB/TrEMBL

D9J300, Q2Q7P0

Related

ENSMUSP00000143343.2, ENSMUST00000200043.5

Conserved Domains (5) summary

cd09453
Location:350 → 401

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15229
Location:215 → 325

POM121; POM121 family

pfam15936
Location:105 → 185

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:468 → 522

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001190856.2 → NP_001177785.1 PDZ and LIM domain protein 5 isoform ENH1d

See identical proteins and their annotated locations for NP_001177785.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks an alternate exon, compared to variant 4. The resulting protein (isoform ENH1d) is shorter when it is compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS80037.1

UniProtKB/TrEMBL

D9J301, Q2Q7P0

Related

ENSMUSP00000142460.2, ENSMUST00000196220.5

Conserved Domains (5) summary

cd09453
Location:398 → 449

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15229
Location:263 → 373

POM121; POM121 family

pfam15936
Location:105 → 185

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:516 → 570

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_001190857.2 → NP_001177786.1 PDZ and LIM domain protein 5 isoform ENH3a

See identical proteins and their annotated locations for NP_001177786.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) has multiple differences in the 3' end, compared to variant 4. The resulting protein (isoform ENH3a) has a shorter and distinct C-terminus when compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS80039.1

UniProtKB/TrEMBL

D9J303

Related

ENSMUSP00000132647.4, ENSMUST00000168967.9

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 201

DUF4749; Domain of unknown function (DUF4749)
NM_001428912.1 → NP_001415841.1 PDZ and LIM domain protein 5 isoform ENH5

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428913.1 → NP_001415842.1 PDZ and LIM domain protein 5 isoform ENH6

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428914.1 → NP_001415843.1 PDZ and LIM domain protein 5 isoform ENH7

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428915.1 → NP_001415844.1 PDZ and LIM domain protein 5 isoform ENH8

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428916.1 → NP_001415845.1 PDZ and LIM domain protein 5 isoform ENH9

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428917.1 → NP_001415846.1 PDZ and LIM domain protein 5 isoform ENH10

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_001428918.1 → NP_001415847.1 PDZ and LIM domain protein 5 isoform ENH11

Status: VALIDATED

Source sequence(s)

AC139128, AC158581
NM_019808.4 → NP_062782.2 PDZ and LIM domain protein 5 isoform ENH1

See identical proteins and their annotated locations for NP_062782.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) uses a different splice site and lacks alternate segments, compared to variant 4. The resulting protein (isoform ENH1) is shorter when it is compared to isoform ENH1e. This isoform has also been called ENH1/1a.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS17875.1

UniProtKB/Swiss-Prot

Q3UGD0, Q8CI51, Q9QYN0, Q9QYN1, Q9QYN2

UniProtKB/TrEMBL

Q2Q7P0

Related

ENSMUSP00000029941.10, ENSMUST00000029941.16

Conserved Domains (5) summary

cd09453
Location:415 → 466

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15741
Location:75 → 388

LRIF1; Ligand-dependent nuclear receptor-interacting factor 1

pfam15936
Location:214 → 294

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:533 → 587

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
NM_019809.4 → NP_062783.2 PDZ and LIM domain protein 5 isoform ENH2

See identical proteins and their annotated locations for NP_062783.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site and has multiple differences in the 3' end, compared to variant 4. The resulting protein (isoform ENH2) is shorter and has a distinct C-terminus when it is compared to isoform ENH1e.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS17876.1

UniProtKB/TrEMBL

Q9CRA2

Related

ENSMUSP00000143098.2, ENSMUST00000196908.5

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 294

DUF4749; Domain of unknown function (DUF4749)
NM_022554.4 → NP_072048.2 PDZ and LIM domain protein 5 isoform ENH3b

See identical proteins and their annotated locations for NP_072048.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) has multiple differences, compared to variant 4. The resulting protein (isoform ENH3b) has a shorter and distinct C-terminus when it is compared to isoform ENH1e. The encoded isoform was previously known as ENH3b.

Source sequence(s)

AC139128, AC158581

Consensus CDS

CCDS38656.1

UniProtKB/TrEMBL

E9Q8P5

Related

ENSMUSP00000128752.3, ENSMUST00000170361.9

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 206

DUF4749; Domain of unknown function (DUF4749)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

141945346..142101480 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319659.2 → XP_017175148.1 PDZ and LIM domain protein 5 isoform X11

Conserved Domains (4) summary

cd09453
Location:424 → 475

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:542 → 596

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:115 → 181

DUF4749; Domain of unknown function (DUF4749)
XM_036163173.1 → XP_036019066.1 PDZ and LIM domain protein 5 isoform X14

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (4) summary

cd09453
Location:354 → 405

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 195

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:472 → 526

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006501748.2 → XP_006501811.1 PDZ and LIM domain protein 5 isoform X15

Conserved Domains (5) summary

PHA03381
Location:132 → 329

PHA03381; tegument protein VP22; Provisional

cd09453
Location:312 → 363

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:430 → 484

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:105 → 201

DUF4749; Domain of unknown function (DUF4749)
XM_036163172.1 → XP_036019065.1 PDZ and LIM domain protein 5 isoform X13

Conserved Domains (4) summary

cd09453
Location:360 → 411

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 201

DUF4749; Domain of unknown function (DUF4749)

cl02475
Location:478 → 532

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006501745.2 → XP_006501808.1 PDZ and LIM domain protein 5 isoform X9

Conserved Domains (4) summary

cd09453
Location:444 → 495

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:562 → 616

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:105 → 201

DUF4749; Domain of unknown function (DUF4749)
XM_006501744.2 → XP_006501807.1 PDZ and LIM domain protein 5 isoform X8

Conserved Domains (5) summary

cd09453
Location:449 → 500

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:508 → 559

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:567 → 621

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

pfam15936
Location:105 → 206

DUF4749; Domain of unknown function (DUF4749)
XM_036163170.1 → XP_036019063.1 PDZ and LIM domain protein 5 isoform X6

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (5) summary

cd09453
Location:507 → 558

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:566 → 617

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:625 → 679

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 304

DUF4749; Domain of unknown function (DUF4749)
XM_006501740.2 → XP_006501803.1 PDZ and LIM domain protein 5 isoform X3

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (5) summary

cd09453
Location:547 → 598

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:606 → 657

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:665 → 719

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 304

DUF4749; Domain of unknown function (DUF4749)
XM_036163171.1 → XP_036019064.1 PDZ and LIM domain protein 5 isoform X12

Conserved Domains (5) summary

cd09453
Location:421 → 472

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:539 → 593

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PHA03307
Location:82 → 403

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:480 → 531

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006501739.2 → XP_006501802.1 PDZ and LIM domain protein 5 isoform X2

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (5) summary

cd09453
Location:553 → 604

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:612 → 663

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:671 → 725

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 310

DUF4749; Domain of unknown function (DUF4749)
XM_006501746.2 → XP_006501809.1 PDZ and LIM domain protein 5 isoform X10

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (5) summary

cd09453
Location:426 → 477

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:544 → 598

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PHA03307
Location:82 → 408

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cl02475
Location:485 → 536

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
XM_006501743.2 → XP_006501806.1 PDZ and LIM domain protein 5 isoform X7

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (6) summary

cd09453
Location:474 → 525

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:533 → 584

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:592 → 646

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PRK12323
Location:79 → 274

PRK12323; DNA polymerase III subunit gamma/tau

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 315

DUF4749; Domain of unknown function (DUF4749)
XM_006501741.2 → XP_006501804.1 PDZ and LIM domain protein 5 isoform X4

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (6) summary

cd09453
Location:518 → 569

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:577 → 628

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:636 → 690

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PHA03307
Location:150 → 537

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 315

DUF4749; Domain of unknown function (DUF4749)
XM_006501742.2 → XP_006501805.1 PDZ and LIM domain protein 5 isoform X5

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (6) summary

cd09453
Location:514 → 565

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:573 → 624

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:632 → 686

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PHA03307
Location:150 → 533

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 315

DUF4749; Domain of unknown function (DUF4749)
XM_006501738.2 → XP_006501801.1 PDZ and LIM domain protein 5 isoform X1

UniProtKB/TrEMBL

Q2Q7P0

Conserved Domains (6) summary

cd09453
Location:558 → 609

LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family

cd09457
Location:617 → 668

LIM2_ENH; The second LIM domain of the Enigma Homolog (ENH) family

cd09459
Location:676 → 730

LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family

PHA03307
Location:150 → 540

PHA03307; transcriptional regulator ICP4; Provisional

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:214 → 315

DUF4749; Domain of unknown function (DUF4749)
XM_006501751.4 → XP_006501814.1 PDZ and LIM domain protein 5 isoform X17

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 201

DUF4749; Domain of unknown function (DUF4749)
XM_006501750.4 → XP_006501813.1 PDZ and LIM domain protein 5 isoform X16

Conserved Domains (2) summary

cd00992
Location:10 → 82

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam15936
Location:105 → 206

DUF4749; Domain of unknown function (DUF4749)