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PDLIM5 PDZ and LIM domain 5 [ Homo sapiens (human) ]

Gene ID: 10611, updated on 4-Nov-2018

Summary

Official Symbol
PDLIM5provided by HGNC
Official Full Name
PDZ and LIM domain 5provided by HGNC
Primary source
HGNC:HGNC:17468
See related
Ensembl:ENSG00000163110 MIM:605904; Vega:OTTHUMG00000130973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L9; ENH; LIM; ENH1
Summary
This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression
Broad expression in heart (RPKM 70.2), prostate (RPKM 31.5) and 23 other tissues See more
Orthologs

Genomic context

See PDLIM5 in Genome Data Viewer
Location:
4q22.3
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (94451857..94668227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (95373008..95589378)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene hematopoietic prostaglandin D synthase Neighboring gene ribosomal protein L35a pseudogene 11 Neighboring gene VISTA enhancer hs1438 Neighboring gene BMPR1B divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
NHGRI GWA Catalog

Pathways from BioSystems

  • Interactions of neurexins and neuroligins at synapses, organism-specific biosystem (from REACTOME)
    Interactions of neurexins and neuroligins at synapses, organism-specific biosystemNeurexins (NRXNs) and neuroligins (NLGNs) are best characterized synaptic cell-adhesion molecules. They are part of excitatory glutamatergic and inhibitory GABAergic synapses in mammalian brain, medi...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
  • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
    Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
actinin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cadherin binding involved in cell-cell adhesion HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell growth involved in cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cell-cell adherens junction HDA PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
PDZ and LIM domain protein 5
Names
enigma homolog
enigma-like LIM domain protein
enigma-like PDZ and LIM domains protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011513.3NP_001011513.3  PDZ and LIM domain protein 5 isoform b

    See identical proteins and their annotated locations for NP_001011513.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AA614664, AC108067, AL832157, DA895978
    Consensus CDS
    CCDS47102.1
    Related
    ENSP00000442187.2, OTTHUMP00000278556, ENST00000542407.5, OTTHUMT00000481781
    Conserved Domains (5) summary
    cd09453
    Location:311362
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:429483
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105185
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:370421
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001011515.2NP_001011515.1  PDZ and LIM domain protein 5 isoform d

    See identical proteins and their annotated locations for NP_001011515.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, lacks several 3' exons but contains an alternate 3' exon, and it thus has an alternate 3' coding region and 3' UTR, compared to isoform a. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA253314, AC093778, AL833151, DA895978
    Consensus CDS
    CCDS47103.1
    UniProtKB/Swiss-Prot
    Q96HC4
    Related
    ENSP00000369527.3, ENST00000380180.7
    Conserved Domains (2) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25776
    Location:105191
    DUF4749; Domain of unknown function (DUF4749)
  3. NM_001011516.2NP_001011516.1  PDZ and LIM domain protein 5 isoform e

    See identical proteins and their annotated locations for NP_001011516.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, lacks several 3' exons but contains an alternate 3' exon, and it thus has an alternate 3' coding region and 3' UTR, compared to isoform a. The encoded isoform (e, also known as ENH4) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA253314, AC093778, AK291898, BC017902, DA895978
    Consensus CDS
    CCDS47104.1
    UniProtKB/Swiss-Prot
    Q96HC4
    Related
    ENSP00000322021.5, ENST00000318007.9
    Conserved Domains (2) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25776
    Location:100171
    DUF4749; Domain of unknown function (DUF4749)
  4. NM_001256425.1NP_001243354.1  PDZ and LIM domain protein 5 isoform c

    See identical proteins and their annotated locations for NP_001243354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA614664, AC108067, BC026029, DA895978
    Consensus CDS
    CCDS75166.1
    Related
    ENSP00000398469.2, ENST00000437932.5
    Conserved Domains (2) summary
    cd09453
    Location:95146
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cl02475
    Location:213267
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. NM_001256426.1NP_001243355.1  PDZ and LIM domain protein 5 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region, and contains four additional in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (f) that is longer than isoform a.
    Source sequence(s)
    AA614664, AC093778, AC108067, AL832686, DA895978
    Consensus CDS
    CCDS58916.1
    Related
    ENSP00000480359.1, ENST00000615540.4
    Conserved Domains (5) summary
    cd09453
    Location:449500
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:567621
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105191
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:508559
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. NM_001256427.1NP_001243356.1  PDZ and LIM domain protein 5 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame splice site in the 5' coding region, contains an additional in-frame exon in the central coding region, and uses alternate 3' exon structure and thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA614664, AC093778, AC108067, AK304125, DA895978
    Consensus CDS
    CCDS58917.1
    UniProtKB/TrEMBL
    B7Z8X5
    Related
    ENSP00000424297.1, OTTHUMP00000219307, ENST00000503974.5, OTTHUMT00000362988
    Conserved Domains (4) summary
    cd09453
    Location:317368
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105191
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:376427
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  7. NM_001256428.1NP_001243357.1  PDZ and LIM domain protein 5 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon in the 5' coding region and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (h) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA614664, AC108067, AK296980, DA895978
    UniProtKB/TrEMBL
    B7Z481
    Conserved Domains (3) summary
    cd09453
    Location:298349
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    pfam15936
    Location:92172
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:416470
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. NM_001256429.1NP_001243358.1  PDZ and LIM domain protein 5 isoform i

    See identical proteins and their annotated locations for NP_001243358.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks several central and 3' exons but contains an alternate 3' exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (i) has the same N-terminus but has a distinct and significantly shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AA922628, AY345240, DA895978
    Consensus CDS
    CCDS58915.1
    UniProtKB/Swiss-Prot
    Q96HC4
    Related
    ENSP00000352210.4, OTTHUMP00000219306, ENST00000359265.8, OTTHUMT00000362987
  9. NM_006457.4NP_006448.4  PDZ and LIM domain protein 5 isoform a

    See identical proteins and their annotated locations for NP_006448.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a (also known as ENH1).
    Source sequence(s)
    AA614664, AC108067, AY598328, BC008741, BF954250, DA895978
    Consensus CDS
    CCDS3641.1
    UniProtKB/Swiss-Prot
    Q96HC4
    UniProtKB/TrEMBL
    A0A024RDE8
    Related
    ENSP00000321746.4, OTTHUMP00000161598, ENST00000317968.8, OTTHUMT00000253586
    Conserved Domains (5) summary
    cd09453
    Location:420471
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:538592
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:214294
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:479530
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RNA

  1. NR_046186.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks several exons in the central and 3' regions, but contains an alternate 3' exon, compared to variant 1. This variant is represented as non-coding because it lacks the majority of the coding region, as found in variant 1, and it does not have any significant coding potential.
    Source sequence(s)
    AA922628, AC109925, DA381128, DA895978

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    94451857..94668227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531543.3XP_011529845.1  PDZ and LIM domain protein 5 isoform X9

    Conserved Domains (5) summary
    cd09453
    Location:424475
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:542596
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:96166
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:483534
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_006714070.3XP_006714133.1  PDZ and LIM domain protein 5 isoform X7

    Conserved Domains (5) summary
    cd09453
    Location:429480
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:547601
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:100171
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:488539
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_006714066.4XP_006714129.1  PDZ and LIM domain protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006714129.1

    Conserved Domains (5) summary
    cd09453
    Location:563614
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:681735
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:214305
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:622673
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_006714069.4XP_006714132.1  PDZ and LIM domain protein 5 isoform X6

    Conserved Domains (5) summary
    cd09453
    Location:431482
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:549603
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:214305
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:490541
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. XM_005262693.5XP_005262750.1  PDZ and LIM domain protein 5 isoform X2

    Conserved Domains (5) summary
    cd09453
    Location:558609
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:676730
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:214300
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:617668
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. XM_017007657.2XP_016863146.1  PDZ and LIM domain protein 5 isoform X8

  7. XM_005262695.5XP_005262752.1  PDZ and LIM domain protein 5 isoform X3

    Conserved Domains (5) summary
    cd09453
    Location:552603
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:670724
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:214294
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:611662
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. XM_005262698.4XP_005262755.1  PDZ and LIM domain protein 5 isoform X11

    Conserved Domains (5) summary
    cd09453
    Location:317368
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:435489
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105191
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:376427
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  9. XM_006714068.3XP_006714131.1  PDZ and LIM domain protein 5 isoform X4

    Conserved Domains (5) summary
    cd09453
    Location:454505
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:572626
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105196
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:513564
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  10. XM_017007658.1XP_016863147.1  PDZ and LIM domain protein 5 isoform X10

  11. XM_005262696.4XP_005262753.1  PDZ and LIM domain protein 5 isoform X5

    Conserved Domains (5) summary
    cd09453
    Location:443494
    LIM1_ENH; The first LIM domain of the Enigma Homolog (ENH) family
    cd09459
    Location:561615
    LIM3_ENH; The third LIM domain of the Enigma Homolog (ENH) family
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam15936
    Location:105185
    DUF4749; Domain of unknown function (DUF4749)
    cl02475
    Location:502553
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  12. XM_024453877.1XP_024309645.1  PDZ and LIM domain protein 5 isoform X12

    Related
    ENSP00000426804.1, ENST00000508216.5
    Conserved Domains (2) summary
    cd00992
    Location:1082
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25776
    Location:105191
    DUF4749; Domain of unknown function (DUF4749)
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